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MeSH Review

Prostatic Intraepithelial Neoplasia

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Disease relevance of Prostatic Intraepithelial Neoplasia


High impact information on Prostatic Intraepithelial Neoplasia


Chemical compound and disease context of Prostatic Intraepithelial Neoplasia


Biological context of Prostatic Intraepithelial Neoplasia


Anatomical context of Prostatic Intraepithelial Neoplasia


Gene context of Prostatic Intraepithelial Neoplasia


Analytical, diagnostic and therapeutic context of Prostatic Intraepithelial Neoplasia


  1. High-grade prostatic intraepithelial neoplasia: additional links to a potentially more aggressive prostate cancer? Sakr, W.A. J. Natl. Cancer Inst. (1998) [Pubmed]
  2. Telomerase activity in prostate cancer, prostatic intraepithelial neoplasia, and benign prostatic epithelium. Zhang, W., Kapusta, L.R., Slingerland, J.M., Klotz, L.H. Cancer Res. (1998) [Pubmed]
  3. Loss of NKX3.1 expression in human prostate cancers correlates with tumor progression. Bowen, C., Bubendorf, L., Voeller, H.J., Slack, R., Willi, N., Sauter, G., Gasser, T.C., Koivisto, P., Lack, E.E., Kononen, J., Kallioniemi, O.P., Gelmann, E.P. Cancer Res. (2000) [Pubmed]
  4. Hypermethylation of the human glutathione S-transferase-pi gene (GSTP1) CpG island is present in a subset of proliferative inflammatory atrophy lesions but not in normal or hyperplastic epithelium of the prostate: a detailed study using laser-capture microdissection. Nakayama, M., Bennett, C.J., Hicks, J.L., Epstein, J.I., Platz, E.A., Nelson, W.G., De Marzo, A.M. Am. J. Pathol. (2003) [Pubmed]
  5. Tumour-suppression activity of the proapoptotic regulator Par4. García-Cao, I., Duran, A., Collado, M., Carrascosa, M.J., Martín-Caballero, J., Flores, J.M., Diaz-Meco, M.T., Moscat, J., Serrano, M. EMBO Rep. (2005) [Pubmed]
  6. Estrogen receptor alpha and imprinting of the neonatal mouse ventral prostate by estrogen. Omoto, Y., Imamov, O., Warner, M., Gustafsson, J.A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  7. Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model. Majumder, P.K., Yeh, J.J., George, D.J., Febbo, P.G., Kum, J., Xue, Q., Bikoff, R., Ma, H., Kantoff, P.W., Golub, T.R., Loda, M., Sellers, W.R. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  8. Conditional loss of Nkx3.1 in adult mice induces prostatic intraepithelial neoplasia. Abdulkadir, S.A., Magee, J.A., Peters, T.J., Kaleem, Z., Naughton, C.K., Humphrey, P.A., Milbrandt, J. Mol. Cell. Biol. (2002) [Pubmed]
  9. Increased expression of osteopontin contributes to the progression of prostate cancer. Khodavirdi, A.C., Song, Z., Yang, S., Zhong, C., Wang, S., Wu, H., Pritchard, C., Nelson, P.S., Roy-Burman, P. Cancer Res. (2006) [Pubmed]
  10. Deletion, methylation, and expression of the NKX3.1 suppressor gene in primary human prostate cancer. Asatiani, E., Huang, W.X., Wang, A., Rodriguez Ortner, E., Cavalli, L.R., Haddad, B.R., Gelmann, E.P. Cancer Res. (2005) [Pubmed]
  11. Targeting tomoregulin for radioimmunotherapy of prostate cancer. Zhao, X.Y., Schneider, D., Biroc, S.L., Parry, R., Alicke, B., Toy, P., Xuan, J.A., Sakamoto, C., Wada, K., Schulze, M., Müller-Tiemann, B., Parry, G., Dinter, H. Cancer Res. (2005) [Pubmed]
  12. Toremifene prevents prostate cancer in the transgenic adenocarcinoma of mouse prostate model. Raghow, S., Hooshdaran, M.Z., Katiyar, S., Steiner, M.S. Cancer Res. (2002) [Pubmed]
  13. Loss-of-function of Nkx3.1 promotes increased oxidative damage in prostate carcinogenesis. Ouyang, X., DeWeese, T.L., Nelson, W.G., Abate-Shen, C. Cancer Res. (2005) [Pubmed]
  14. High-level expression of EphA2 receptor tyrosine kinase in prostatic intraepithelial neoplasia. Zeng, G., Hu, Z., Kinch, M.S., Pan, C.X., Flockhart, D.A., Kao, C., Gardner, T.A., Zhang, S., Li, L., Baldridge, L.A., Koch, M.O., Ulbright, T.M., Eble, J.N., Cheng, L. Am. J. Pathol. (2003) [Pubmed]
  15. Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival. Yang, G., Ayala, G., De Marzo, A., Tian, W., Frolov, A., Wheeler, T.M., Thompson, T.C., Harper, J.W. Clin. Cancer Res. (2002) [Pubmed]
  16. Elevated expression of estramustine binding protein (EMBP) in prostatic intraepithelial neoplasia (PIN) compared with malignant and benign prostatic epithelia. de la Torre, M., Eklöv, S., Häggman, M., Björk, P., Busch, C., Nilsson, S. Prostate (1994) [Pubmed]
  17. Stem cell features of benign and malignant prostate epithelial cells. De Marzo, A.M., Nelson, W.G., Meeker, A.K., Coffey, D.S. J. Urol. (1998) [Pubmed]
  18. CG island methylation changes near the GSTP1 gene in prostatic intraepithelial neoplasia. Brooks, J.D., Weinstein, M., Lin, X., Sun, Y., Pin, S.S., Bova, G.S., Epstein, J.I., Isaacs, W.B., Nelson, W.G. Cancer Epidemiol. Biomarkers Prev. (1998) [Pubmed]
  19. Immunohistochemical expression of retinoblastoma and p53 tumor suppressor genes in prostatic intraepithelial neoplasia: comparison with prostatic adenocarcinoma and benign prostate. Tamboli, P., Amin, M.B., Xu, H.J., Linden, M.D. Mod. Pathol. (1998) [Pubmed]
  20. Expression-patterns of the RNA component (hTR)and the catalytic subunit (hTERT) of human telomerase in nonneoplastic prostate tissue, prostatic intraepithelial neoplasia, and prostate cancer. Bettendorf, O., Heine, B., Kneif, S., Eltze, E., Semjonow, A., Herbst, H., Stein, H., Böcker, W., Poremba, C. Prostate (2003) [Pubmed]
  21. Interaction of Nkx3.1 and p27kip1 in prostate tumor initiation. Gary, B., Azuero, R., Mohanty, G.S., Bell, W.C., Eltoum, I.E., Abdulkadir, S.A. Am. J. Pathol. (2004) [Pubmed]
  22. Comparative studies of the estrogen receptors beta and alpha and the androgen receptor in normal human prostate glands, dysplasia, and in primary and metastatic carcinoma. Leav, I., Lau, K.M., Adams, J.Y., McNeal, J.E., Taplin, M.E., Wang, J., Singh, H., Ho, S.M. Am. J. Pathol. (2001) [Pubmed]
  23. Increased expression of galectin-1 in carcinoma-associated stroma predicts poor outcome in prostate carcinoma patients. van den Brûle, F.A., Waltregny, D., Castronovo, V. J. Pathol. (2001) [Pubmed]
  24. The frequency of carcinoma and intraepithelial neoplasia of the prostate in young male patients. Sakr, W.A., Haas, G.P., Cassin, B.F., Pontes, J.E., Crissman, J.D. J. Urol. (1993) [Pubmed]
  25. A potential autocrine role for vascular endothelial growth factor in prostate cancer. Jackson, M.W., Roberts, J.S., Heckford, S.E., Ricciardelli, C., Stahl, J., Choong, C., Horsfall, D.J., Tilley, W.D. Cancer Res. (2002) [Pubmed]
  26. Cooperation between ectopic FGFR1 and depression of FGFR2 in induction of prostatic intraepithelial neoplasia in the mouse prostate. Jin, C., McKeehan, K., Guo, W., Jauma, S., Ittmann, M.M., Foster, B., Greenberg, N.M., McKeehan, W.L., Wang, F. Cancer Res. (2003) [Pubmed]
  27. Gastrin-releasing peptide receptors in the human prostate: relation to neoplastic transformation. Markwalder, R., Reubi, J.C. Cancer Res. (1999) [Pubmed]
  28. Sonic hedgehog regulates prostatic growth and epithelial differentiation. Freestone, S.H., Marker, P., Grace, O.C., Tomlinson, D.C., Cunha, G.R., Harnden, P., Thomson, A.A. Dev. Biol. (2003) [Pubmed]
  29. Reduced infiltration of class A scavenger receptor positive antigen-presenting cells is associated with prostate cancer progression. Yang, G., Addai, J., Tian, W.H., Frolov, A., Wheeler, T.M., Thompson, T.C. Cancer Res. (2004) [Pubmed]
  30. Differential expression of laminin 5 (alpha 3 beta 3 gamma 2) by human malignant and normal prostate. Hao, J., Yang, Y., McDaniel, K.M., Dalkin, B.L., Cress, A.E., Nagle, R.B. Am. J. Pathol. (1996) [Pubmed]
  31. Evidence for prostate cancer-associated diagnostic marker-1: immunohistochemistry and in situ hybridization studies. Ohkia, A., Hu, Y., Wang, M., Garcia, F.U., Stearns, M.E. Clin. Cancer Res. (2004) [Pubmed]
  32. High-grade prostatic intraepithelial neoplasia on needle biopsy: risk of cancer on repeat biopsy related to number of involved cores and morphologic pattern. Bishara, T., Ramnani, D.M., Epstein, J.I. Am. J. Surg. Pathol. (2004) [Pubmed]
  33. Prostatic intraepithelial neoplasia: influence of clinical and pathological data on the detection of prostate cancer. Raviv, G., Janssen, T., Zlotta, A.R., Descamps, F., Verhest, A., Schulman, C.C. J. Urol. (1996) [Pubmed]
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