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Gene Review

POLR2F  -  polymerase (RNA) II (DNA directed)...

Homo sapiens

Synonyms: DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerases I, II, and III 14.4 kDa polypeptide, DNA-directed RNA polymerases I, II, and III subunit RPABC2, HRBP14.4, POLRF, ...
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High impact information on POLR2F

  • Using the protozoan parasite Trypanosoma brucei as a model organism, we demonstrate that these distinct RPB5 and RPB6 subunits localize to discrete subnuclear compartments and form part of different polymerase complexes [1].
  • Genomic structure of the RNA polymerase II small subunit (hRPB14.4) locus (POLRF) and mapping to 22q13.1 by sequence identity [2].
  • By doing so, we were able to identify GAPD, M-RIP, and POLR2F as stable and usable reference genes irrespective of differentiation status and Abeta(42) treatment [3].
  • The RPB6 cDNA of chicken, encoding one of the small subunits common to all three nuclear DNA-dependent RNA polymerases, has been isolated from an expression cDNA library by screening with a differential display derived probe, representing a gene shown to be highly up-regulated in early heart development [4].

Anatomical context of POLR2F


Analytical, diagnostic and therapeutic context of POLR2F

  • When used for immunofluorescence, antibodies against the subunits shared by all three polymerases (i.e., RPB6, RPB8) gave a few bright foci in nucleoli and nucleoplasm, as well as many fainter nucleoplasmic foci; all the bright foci were generally distinct from speckles containing Sm antigen [6].


  1. Diversification of function by different isoforms of conventionally shared RNA polymerase subunits. Devaux, S., Kelly, S., Lecordier, L., Wickstead, B., Perez-Morga, D., Pays, E., Vanhamme, L., Gull, K. Mol. Biol. Cell (2007) [Pubmed]
  2. Genomic structure of the RNA polymerase II small subunit (hRPB14.4) locus (POLRF) and mapping to 22q13.1 by sequence identity. Pusch, C., Wang, Z., Roe, B., Blin, N. Genomics (1996) [Pubmed]
  3. Reference genes identified in SH-SY5Y cells using custom-made gene arrays with validation by quantitative polymerase chain reaction. Hoerndli, F.J., Toigo, M., Schild, A., Götz, J., Day, P.J. Anal. Biochem. (2004) [Pubmed]
  4. Isolation and characterisation of a chick cDNA encoding the RNA polymerase common subunit RPB6. Kaarbo, M., Crane, D.I., Murrell, W.G. DNA Seq. (2000) [Pubmed]
  5. A 14.4 KDa acidic subunit of human RNA polymerase II with a putative leucine-zipper. Acker, J., Wintzerith, M., Vigneron, M., Kedinger, C. DNA Seq. (1994) [Pubmed]
  6. Isolation and characterization of monoclonal antibodies directed against subunits of human RNA polymerases I, II, and III. Jones, E., Kimura, H., Vigneron, M., Wang, Z., Roeder, R.G., Cook, P.R. Exp. Cell Res. (2000) [Pubmed]
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