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Gene Review

Polr2f  -  polymerase (RNA) II (DNA directed)...

Mus musculus

Synonyms: 1810060D16Rik, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerases I, II, and III subunit RPABC2, RNA Pol II, RNA polymerases I, II, and III subunit ABC2, ...
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High impact information on Polr2f


Biological context of Polr2f


Anatomical context of Polr2f


Associations of Polr2f with chemical compounds

  • Our results further showed that the transcriptionally active form of RNA Pol II LS containing phosphoserine in position 2 of the CTD repeats was restricted to the nucleus and its levels remained remarkably constant [6].
  • In ChIP assays conducted with an antibody to RNA polymerase II (RNA Pol II), the association of RNA Pol II with PEPCK RARE1/RARE2 was significantly decreased in vitamin A deficiency [7].

Analytical, diagnostic and therapeutic context of Polr2f

  • Immunofluorescence microscopy studies revealed that monomethylated H4-Lys(20) mainly overlaps with RNA pol II-stained euchromatic regions, thus indicating an association with transcriptionally engaged chromatin [8].


  1. A role for coactivators and histone acetylation in estrogen receptor alpha-mediated transcription initiation. Kim, M.Y., Hsiao, S.J., Kraus, W.L. EMBO J. (2001) [Pubmed]
  2. The oncogenic TLS-ERG fusion protein exerts different effects in hematopoietic cells and fibroblasts. Zou, J., Ichikawa, H., Blackburn, M.L., Hu, H.M., Zielinska-Kwiatkowska, A., Mei, Q., Roth, G.J., Chansky, H.A., Yang, L. Mol. Cell. Biol. (2005) [Pubmed]
  3. Sequential histone modifications at Hoxd4 regulatory regions distinguish anterior from posterior embryonic compartments. Rastegar, M., Kobrossy, L., Kovacs, E.N., Rambaldi, I., Featherstone, M. Mol. Cell. Biol. (2004) [Pubmed]
  4. BRCA1 associates with processive RNA polymerase II. Krum, S.A., Miranda, G.A., Lin, C., Lane, T.F. J. Biol. Chem. (2003) [Pubmed]
  5. Molecular characterization and developmental expression of the TFIIH factor p62 gene from Drosophila melanogaster: effects on the UV light sensitivity of a p62 mutant fly. Castro, J., Merino, C., Zurita, M. DNA Repair (Amst.) (2002) [Pubmed]
  6. Abundance of the largest subunit of RNA polymerase II in the nucleus is regulated by nucleo-cytoplasmic shuttling. Custódio, N., Antoniou, M., Carmo-Fonseca, M. Exp. Cell Res. (2006) [Pubmed]
  7. RNA polymerase II association with the phosphoenolpyruvate carboxykinase (PEPCK) promoter is reduced in vitamin A-deficient mice. Scribner, K.B., McGrane, M.M. J. Nutr. (2003) [Pubmed]
  8. Histone H4-lysine 20 monomethylation is increased in promoter and coding regions of active genes and correlates with hyperacetylation. Talasz, H., Lindner, H.H., Sarg, B., Helliger, W. J. Biol. Chem. (2005) [Pubmed]
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