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Gene Review:

Zfp326 - zinc finger protein 326

Mus musculus

Synonyms: 5730470H14Rik, DBIRD complex subunit ZNF326, ZAN75, Zan75, Zinc finger protein 326, ...

Lee, J.Y. et al., Lee, J.Y. et al.

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Disease relevance of Zfp326

In this study, we characterized the nuclear localization signal of ZAN75, tested if ZAN75 regulates transcription, and examined its expression during embryonic development and neuronal differentiation of P19 mouse embryonal carcinoma cells [1].

High impact information on Zfp326

Characterization of a zinc finger protein ZAN75: nuclear localization signal, transcriptional activator activity, and expression during neuronal differentiation of P19 cells [1].
The expression of ZAN75 was transiently increased at both the mRNA and the protein levels when P19 cells were treated with retinoic acid to induce neuronal differentiation [1].
Southern blot analysis demonstrated that the ZAN75 gene exists in a single copy in the mouse genome and that a closely related gene is also present in chicken, rat, and human [2].

Anatomical context of Zfp326

The ZAN75 cDNA was first identified in NIH 3T3 cells and codes for a DNA-binding protein with two zinc finger motifs [1].

Analytical, diagnostic and therapeutic context of Zfp326

Northern blot analysis showed that the ZAN75 gene is ubiquitously expressed in adult mouse tissues [2].

References

Characterization of a zinc finger protein ZAN75: nuclear localization signal, transcriptional activator activity, and expression during neuronal differentiation of P19 cells. Lee, J.Y., Nakane, Y., Koshikawa, N., Nakayama, K., Hayashi, M., Takenaga, K. DNA Cell Biol. (2000) [Pubmed]
Cloning and characterization of a novel zinc finger protein that associates with nuclear matrix. Lee, J.Y., Kambe, M., Hayashi, M., Takenaga, K. DNA Cell Biol. (1998) [Pubmed]

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ZNF326	Canis lupus familiaris
znf326	Danio rerio
ZNF326	Gallus gallus
ZNF326	Homo sapiens
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znf326	Xenopus (Silurana) tropicalis

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