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Gene Review

POLR2H  -  polymerase (RNA) II (DNA directed)...

Homo sapiens

Synonyms: DNA-directed RNA polymerase II subunit H, DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide, DNA-directed RNA polymerases I, II, and III subunit RPABC3, RNA polymerases I, II, and III subunit ABC3, RPABC3, ...
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High impact information on POLR2H

  • To assess functional relatedness of individual components of the eukaryotic transcription apparatus, three human subunits (hsRPB5, hsRPB8, and hsRPB10) were tested for their ability to support yeast cell growth in the absence of their essential yeast homologs [1].
  • Two of the three subunits, hsRPB8 and hsRPB10, supported normal yeast cell growth at moderate temperatures [1].
  • Hs8 complemented a yeast mutant (rpb8-delta 1::LYS2) defective in the corresponding Sc8 subunit, although with a strong thermosensitive phenotype [2].
  • We have found that in murine fibroblasts exposure to alpha-amanitin triggered degradation of the RPB1 subunit, while other RNAPII subunits, RPB5 and RPB8, remained almost unaffected [3].
  • We report that growth of 8701-BC cells on OF/LB collagen is consistently associated with the up-regulation of hRPB17 gene, coding for an RNA polymerase subunit, as confirmed by conventional RT-PCR and Northern analyses [4].

Analytical, diagnostic and therapeutic context of POLR2H

  • When used for immunofluorescence, antibodies against the subunits shared by all three polymerases (i.e., RPB6, RPB8) gave a few bright foci in nucleoli and nucleoplasm, as well as many fainter nucleoplasmic foci; all the bright foci were generally distinct from speckles containing Sm antigen [5].


  1. Six human RNA polymerase subunits functionally substitute for their yeast counterparts. McKune, K., Moore, P.A., Hull, M.W., Woychik, N.A. Mol. Cell. Biol. (1995) [Pubmed]
  2. Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae. Shpakovski, G.V., Acker, J., Wintzerith, M., Lacroix, J.F., Thuriaux, P., Vigneron, M. Mol. Cell. Biol. (1995) [Pubmed]
  3. In vivo degradation of RNA polymerase II largest subunit triggered by alpha-amanitin. Nguyen, V.T., Giannoni, F., Dubois, M.F., Seo, S.J., Vigneron, M., Kédinger, C., Bensaude, O. Nucleic Acids Res. (1996) [Pubmed]
  4. Collagen-induced differential expression of an RNA polymerase subunit by breast cancer cells. Sirchia, R., Luparello, C. Biochimie (2005) [Pubmed]
  5. Isolation and characterization of monoclonal antibodies directed against subunits of human RNA polymerases I, II, and III. Jones, E., Kimura, H., Vigneron, M., Wang, Z., Roeder, R.G., Cook, P.R. Exp. Cell Res. (2000) [Pubmed]
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