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POLR2J  -  polymerase (RNA) II (DNA directed)...

Homo sapiens

Synonyms: DNA-directed RNA polymerase II subunit J-1, DNA-directed RNA polymerase II subunit RPB11-a, POLR2J1, RNA polymerase II 13.3 kDa subunit, RNA polymerase II subunit B11-a, ...
 
 
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Disease relevance of POLR2J

  • Taken together, these findings suggest that the interaction between hRPB3 and hRPB11 is fundamental for their function and that this heterodimer is involved in doxorubicin toxicity [1].
 

High impact information on POLR2J

  • hRPB11 is a core subunit of RNA polymerase II (pol II) specifically down-regulated on doxorubicin (dox) treatment [2].
  • Both hRPB11 and hRPB3 transcripts share a similar pattern of distribution in human adult tissues, with particularly high levels in both heart and skeletal muscle, and the expression of both is down-regulated by doxorubicin as found previously for the hRPB11 subunit [1].
  • Finally, the role played by hRPB11 in regulating the transcription of specific genes is underlined by transient transfection experiments that show transactivation of the E-cadherin promoter by this protein [3].
  • We have previously shown that the human RNA polymerase II subunit 11 (hRPB11) is among the proteins specifically downregulated upon Doxorubicin (Dox) treatment of human cancer cell lines, and that Dox resistant clones derived upon drug selection express about 20% of the protein present in the original parental cell line [3].
  • The evolutionary emergence of a probable eukaryotic heterodimer, hRPB14/hRPB33, from a prokaryotic homodimer, alpha 2, is hypothesized [4].
 

Biological context of POLR2J

  • RESULTS: While those characterized so far for the human (h) RPB are also unique, we show that hRPB subunit 11 (hRPB11) is encoded by a multigene family, mapping on chromosome 7 at loci p12, q11.23 and q22 [5].

References

  1. The interacting RNA polymerase II subunits, hRPB11 and hRPB3, are coordinately expressed in adult human tissues and down-regulated by doxorubicin. Fanciulli, M., Bruno, T., Di Padova, M., De Angelis, R., Lovari, S., Floridi, A., Passananti, C. FEBS Lett. (1998) [Pubmed]
  2. Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb. Fanciulli, M., Bruno, T., Di Padova, M., De Angelis, R., Iezzi, S., Iacobini, C., Floridi, A., Passananti, C. FASEB J. (2000) [Pubmed]
  3. Levels of expression of hRPB11, a core subassembly subunit of human RNA polymerase II, affect doxorubicin sensitivity and cellular differentiation. Bruno, T., Leonetti, C., Aloe, S., Iacobini, C., Floridi, A., Di Tondo, U., Punturieri, A., Fanciulli, M. FEBS Lett. (1998) [Pubmed]
  4. Human RNA polymerase II subunit hRPB14 is homologous to yeast RNA polymerase I, II, and III subunits (AC19 and RPB11) and is similar to a portion of the bacterial RNA polymerase alpha subunit. Pati, U.K. Gene (1994) [Pubmed]
  5. A human RNA polymerase II subunit is encoded by a recently generated multigene family. Grandemange, S., Schaller, S., Yamano, S., Du Manoir, S., Shpakovski, G.V., Mattei, M.G., Kedinger, C., Vigneron, M. BMC Mol. Biol. (2001) [Pubmed]
 
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