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Gene Review

POLR2C  -  polymerase (RNA) II (DNA directed)...

Homo sapiens

Synonyms: A-152E5.7, DNA-directed RNA polymerase II 33 kDa polypeptide, DNA-directed RNA polymerase II subunit C, DNA-directed RNA polymerase II subunit RPB3, RNA polymerase II subunit 3, ...
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Disease relevance of POLR2C

  • Taken together, these findings suggest that the interaction between hRPB3 and hRPB11 is fundamental for their function and that this heterodimer is involved in doxorubicin toxicity [1].

High impact information on POLR2C


Biological context of POLR2C


Associations of POLR2C with chemical compounds


Analytical, diagnostic and therapeutic context of POLR2C

  • PCR detection of the MspI polymorphism in the human IRBP gene (RPB3) [5].


  1. The interacting RNA polymerase II subunits, hRPB11 and hRPB3, are coordinately expressed in adult human tissues and down-regulated by doxorubicin. Fanciulli, M., Bruno, T., Di Padova, M., De Angelis, R., Lovari, S., Floridi, A., Passananti, C. FEBS Lett. (1998) [Pubmed]
  2. The amino acid sequence of the human RNA polymerase II 33-kDa subunit hRPB 33 is highly conserved among eukaryotes. Pati, U.K., Weissman, S.M. J. Biol. Chem. (1990) [Pubmed]
  3. The RNA polymerase II core subunit 11 interacts with keratin 19, a component of the intermediate filament proteins. Bruno, T., Corbi, N., Di Padova, M., De Angelis, R., Floridi, A., Passananti, C., Fanciulli, M. FEBS Lett. (1999) [Pubmed]
  4. A rapid purification method for human RNA polymerase II by two-step affinity chromatography. Hasegawa, J., Endou, M., Narita, T., Yamada, T., Yamaguchi, Y., Wada, T., Handa, H. J. Biochem. (2003) [Pubmed]
  5. PCR detection of the MspI polymorphism in the human IRBP gene (RPB3). Wu, J., Nickerson, J.M. Nucleic Acids Res. (1991) [Pubmed]
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