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Gene Review

MTMR12  -  myotubularin related protein 12

Homo sapiens

Synonyms: 3-PAP, 3-phosphatase adapter protein, 3PAP, FLJ20476, KIAA1682, ...
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Disease relevance of MTMR12

  • These results indicate that the TP-3-PAP immunotoxin may be useful in the treatment of osteosarcoma and some soft tissue sarcomas [1].
  • When TP-3-PAP (1.25 micrograms-10.0 micrograms) was given i.p. q.d. on days 3-5 after tumor inoculation, a dose-dependent reduction of the number of lung metastases was observed (P < 0.001) [1].

High impact information on MTMR12

  • We have now identified myotubularin as the catalytically active 3-phosphatase subunit interacting with 3-PAP [2].
  • Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP [2].
  • 3-PAP immunoprecipitates isolated from platelet cytosol hydrolyzed the D3-phosphate from PtdIns(3)P and PtdIns 3,4-bisphosphate [PtdIns(3,4)P(2)] [3].
  • The 3-PAP sequence contains several motifs that predict interaction with proteins containing Src homology-2 (SH2) domains, phosphotyrosine-binding (PTB) domains, members of the 14-3-3 family, as well as proteins with SET domains [3].
  • After 48 h no viable human OHS osteosarcoma cells were present in cultures containing TP-3-PAP as demonstrated by the absence of [3H]thymidine uptake into DNA [1].

Biological context of MTMR12


Anatomical context of MTMR12

  • Association between 3-PAP and myotubularin was confirmed by reciprocal coimmunoprecipitation of both endogenous and recombinant proteins expressed in K562 cells [2].

Other interactions of MTMR12

  • We have previously reported the identification of the 3-phosphatase adapter protein (3-PAP), a catalytically inactive member of the myotubularin gene family, which coprecipitates lipid phosphatidylinositol 3-phosphate-3-phosphatase activity from lysates of human platelets [2].
  • Progression of the disease to the bone occurred in 20 patients: in 17 PSA was the first indicator of progression, in the other 3 PAP anticipated PSA for a very short time (3-4 months), which was not of relevance to clinical decisions [4].


  1. In vitro and in vivo cytotoxicity of an anti-osteosarcoma immunotoxin containing pokeweed antiviral protein. Anderson, P.M., Meyers, D.E., Hasz, D.E., Covalcuic, K., Saltzman, D., Khanna, C., Uckun, F.M. Cancer Res. (1995) [Pubmed]
  2. Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP. Nandurkar, H.H., Layton, M., Laporte, J., Selan, C., Corcoran, L., Caldwell, K.K., Mochizuki, Y., Majerus, P.W., Mitchell, C.A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. Characterization of an adapter subunit to a phosphatidylinositol (3)P 3-phosphatase: identification of a myotubularin-related protein lacking catalytic activity. Nandurkar, H.H., Caldwell, K.K., Whisstock, J.C., Layton, M.J., Gaudet, E.A., Norris, F.A., Majerus, P.W., Mitchell, C.A. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  4. Prostate-specific antigen as a unique routine test in monitoring therapy for inoperable prostate cancer: comparison with radionuclide bone scan and prostatic acid phosphatase. Barichello, M., Gion, M., Bonazza, A., Delli Ponti, U.S., Bolgan, A., Contemori, G.P., Barioli, P., Capitanio, G., Pecori, B., Omacini, S. Eur. Urol. (1995) [Pubmed]
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