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Gene Review

POU3F2  -  POU class 3 homeobox 2

Homo sapiens

Synonyms: BRN2, Brain-2, Brain-specific homeobox/POU domain protein 2, Brn-2, N-Oct3, ...
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Disease relevance of POU3F2

  • Furthermore, N-Oct 3 (brain-2) was also found in SCLC-derived skin metastasis [1].
  • Human small cell lung cancer expresses the octamer DNA-binding and nervous system-specific transcription factor N-Oct 3 (brain-2) [1].
  • In contrast, in extracts and RNA of non-SCLC cell lines and non-SCLC tumor tissues, such as lung squamous, large cell, and adenocarcinoma, expression of N-Oct 3 (brain-2) was not detectable [1].
  • The BRN2 transcription factor (POU3F2, N-Oct-3) has been implicated in development of the melanocytic lineage and in melanoma [2].
  • Molecular characterization of a novel BR-2 gene that is down-regulated in human low grade glioma tumors [3].

High impact information on POU3F2

  • The present study shows the nervous system-specific transcription factor N-Oct 3 (brain-2) to be expressed in all 13 SCLC cell lines investigated [1].
  • These data support the concept that SCLC cells derive from the neuroectodermal cell lineage since expression of N-Oct 3 (brain-2) protein is highly abundant at the neural tube stage and in the adult restricted to the neuroectodermal cell lineage [1].
  • Furthermore, the Oct family protein Brn-2, which cannot recruit OCA-B, repressed NFAT/Oct enhancer activity [4].
  • The POU factor N-Oct3 (Brn 2 or POU3F2) is also present in sensory neurons and binds viral TAATGARAT motifs with higher affinity than Oct-1, indicating that it may be a candidate repressor for competitive binding to TAATGARAT motifs [5].
  • Of these, the POU domain factor BRN2 and the SOX family member SOX10 are both highly expressed in unpigmented melanocyte precursors but are down-regulated upon differentiation [6].

Biological context of POU3F2


Anatomical context of POU3F2


Associations of POU3F2 with chemical compounds

  • Antagonists were also identified of the related BRN1/DNA and BRN2/DNA transcription factor complexes indicating that a 1,4-disubstituted naphthalene may be a privileged scaffold for preparing screening libraries targeting this family of transcription factor complexes [12].
  • [18F]altanserin studies were conducted in seven subjects using the bolus/infusion approach designed for attaining steady state in blood and brain 2 hours after the initial [18F]altanserin administration [13].

Other interactions of POU3F2


Analytical, diagnostic and therapeutic context of POU3F2

  • RT-PCR analysis indicated that the BR-2 gene is expressed at high levels in two of the five normal brain tissue samples analyzed [3].


  1. Human small cell lung cancer expresses the octamer DNA-binding and nervous system-specific transcription factor N-Oct 3 (brain-2). Schreiber, E., Himmelmann, A., Malipiero, U., Tobler, A., Stahel, R., Fontana, A. Cancer Res. (1992) [Pubmed]
  2. Human melanoblasts in culture: expression of BRN2 and synergistic regulation by fibroblast growth factor-2, stem cell factor, and endothelin-3. Cook, A.L., Donatien, P.D., Smith, A.G., Murphy, M., Jones, M.K., Herlyn, M., Bennett, D.C., Leonard, J.H., Sturm, R.A. J. Invest. Dermatol. (2003) [Pubmed]
  3. Molecular characterization of a novel BR-2 gene that is down-regulated in human low grade glioma tumors. Wei, K.C., Berger, M.S., Sehgal, A. Anticancer Res. (2002) [Pubmed]
  4. Reconstitution of T cell-specific transcription directed by composite NFAT/Oct elements. Bert, A.G., Burrows, J., Hawwari, A., Vadas, M.A., Cockerill, P.N. J. Immunol. (2000) [Pubmed]
  5. Transcription factors interacting with herpes simplex virus alpha gene promoters in sensory neurons. Hagmann, M., Georgiev, O., Schaffner, W., Douville, P. Nucleic Acids Res. (1995) [Pubmed]
  6. Co-expression of SOX9 and SOX10 during melanocytic differentiation in vitro. Cook, A.L., Smith, A.G., Smit, D.J., Leonard, J.H., Sturm, R.A. Exp. Cell Res. (2005) [Pubmed]
  7. Isolation of the human genomic brain-2/N-Oct 3 gene (POUF3) and assignment to chromosome 6q16. Atanasoski, S., Toldo, S.S., Malipiero, U., Schreiber, E., Fries, R., Fontana, A. Genomics (1995) [Pubmed]
  8. Cooperative dimerization of the POU domain protein Brn-2 on a new motif activates the neuronal promoter of the human aromatic L-amino acid decarboxylase gene. Dugast-Darzacq, C., Egloff, S., Weber, M.J. Brain Res. Mol. Brain Res. (2004) [Pubmed]
  9. Rb induces a proliferative arrest and curtails Brn-2 expression in retinoblastoma cells. Cobrinik, D., Francis, R.O., Abramson, D.H., Lee, T.C. Mol. Cancer (2006) [Pubmed]
  10. Curative radiotherapy for primary orbital lymphoma. Bhatia, S., Paulino, A.C., Buatti, J.M., Mayr, N.A., Wen, B.C. Int. J. Radiat. Oncol. Biol. Phys. (2002) [Pubmed]
  11. Winged helix hepatocyte nuclear factor 3 and POU-domain protein brn-2/N-oct-3 bind overlapping sites on the neuronal promoter of human aromatic L-amino acid decarboxylase gene. Raynal, J.F., Dugast, C., Le Van Thaï, A., Weber, M.J. Brain Res. Mol. Brain Res. (1998) [Pubmed]
  12. Privileged scaffolds for blocking protein-protein interactions: 1,4-disubstituted naphthalene antagonists of transcription factor complex HOX-PBX/DNA. Ji, T., Lee, M., Pruitt, S.C., Hangauer, D.G. Bioorg. Med. Chem. Lett. (2004) [Pubmed]
  13. [18F]altanserin binding to human 5HT2A receptors is unaltered after citalopram and pindolol challenge. Pinborg, L.H., Adams, K.H., Yndgaard, S., Hasselbalch, S.G., Holm, S., Kristiansen, H., Paulson, O.B., Knudsen, G.M. J. Cereb. Blood Flow Metab. (2004) [Pubmed]
  14. Exclusion of mutations in the PRNP, JPH3, TBP, ATN1, CREBBP, POU3F2 and FTL genes as a cause of disease in Portuguese patients with a Huntington-like phenotype. Costa, M.d.o. .C., Teixeira-Castro, A., Constante, M., Magalhães, M., Magalhães, P., Cerqueira, J., Vale, J., Passão, V., Barbosa, C., Robalo, C., Coutinho, P., Barros, J., Santos, M.M., Sequeiros, J., Maciel, P. J. Hum. Genet. (2006) [Pubmed]
  15. NF-Y binding is required for transactivation of neuronal aromatic L-amino acid decarboxylase gene promoter by the POU-domain protein Brn-2. Dugast, C., Weber, M.J. Brain Res. Mol. Brain Res. (2001) [Pubmed]
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