Disease relevance of pou1

• In addition, the ubiquitous POU transcription factor Oct-1 or its isolated POU domain enhances adenovirus DNA replication [1].

High impact information on pou1

• In contrast to the Pou2 product, the t-Pou2 product lacks DNA-binding activity because of its incomplete POU domain structure [2].
• POU domain proteins are a large family of transcriptional regulatory proteins, many of which are implicated in the control of gene expression during early development [2].
• The zebrafish spiel-ohne-grenzen (spg) gene encodes the POU domain protein Pou2 related to mammalian Oct4 and is essential for formation of the midbrain and hindbrain, and for pre-gastrula morphogenesis [3].
• We report the characterization of the zebrafish zp-50 class III POU domain gene [4].
• The Pou domain transcription factor Pit-1 is required for lineage determination and cellular commitment processes during mammalian adenohypophysis development [5].

Biological context of pou1

• Northern blot analysis revealed that the ZFPOU1 transcripts first appeared at the early neurula stage of embryogenesis and transiently increased thereafter [6].
• The ZFPOU1 cDNA contained an open reading frame encoding a 425 amino acid peptide [6].
• The deduced amino acid sequence of the reading frame was most similar to that of the mouse class III POU-domain gene, Brain-1 [6].
• We have isolated a POU domain-containing cDNA (ZFPOU1) from a cDNA library of zebrafish (Brachydanio rerio) [6].
• Genetic data have demonstrated that some POU domain proteins are essential for the proliferation of specific cell types, suggesting a possible role in DNA replication [1].

Anatomical context of pou1

• The POU domain protein spg (pou2/Oct4) is essential for endoderm formation in cooperation with the HMG domain protein casanova [7].

Associations of pou1 with chemical compounds

• The 453 amino acids long region N-terminal to the POU domain contains several features typical of transcriptional activation domains such as an acidic region with a putative amphipathic alpha-helix, a glutamine-rich region, and short threonine- and/or serine-rich regions [8].

Other interactions of pou1

• The expression of brn-3b in the mechanosensory lateral line of fish suggests a conserved function of a class IV POU domain transcription factor in sensory system development [9].

Analytical, diagnostic and therapeutic context of pou1

• In situ hybridization analysis demonstrated that the ZFPOU1 transcripts were localized in the neural tissues of embryos, but not in mesodermal, endodermal or ectodermal tissues [6].
• Using redundant primers in a PCR based cloning strategy, POU-domain encoding sequences representing two different class III genes (brain-1.1, brain-1.2) and one class IV gene (brain-3.1) were identified in zebrafish [10].

References