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Gene Review

pou3f3b  -  POU class 3 homeobox 3b

Danio rerio

Synonyms: Brain-1.0, Brain-specific homeobox/POU domain protein 1.0, POU domain protein 1, POU domain protein 23, POU domain, class 3, transcription factor 3-B, ...
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Disease relevance of pou1


High impact information on pou1


Biological context of pou1


Anatomical context of pou1


Associations of pou1 with chemical compounds

  • The 453 amino acids long region N-terminal to the POU domain contains several features typical of transcriptional activation domains such as an acidic region with a putative amphipathic alpha-helix, a glutamine-rich region, and short threonine- and/or serine-rich regions [8].

Other interactions of pou1

  • The expression of brn-3b in the mechanosensory lateral line of fish suggests a conserved function of a class IV POU domain transcription factor in sensory system development [9].

Analytical, diagnostic and therapeutic context of pou1

  • In situ hybridization analysis demonstrated that the ZFPOU1 transcripts were localized in the neural tissues of embryos, but not in mesodermal, endodermal or ectodermal tissues [6].
  • Using redundant primers in a PCR based cloning strategy, POU-domain encoding sequences representing two different class III genes (brain-1.1, brain-1.2) and one class IV gene (brain-3.1) were identified in zebrafish [10].


  1. POU domain transcription factors from different subclasses stimulate adenovirus DNA replication. Verrijzer, C.P., Strating, M., Mul, Y.M., van der Vliet, P.C. Nucleic Acids Res. (1992) [Pubmed]
  2. A novel POU domain gene, zebrafish pou2: expression and roles of two alternatively spliced twin products in early development. Takeda, H., Matsuzaki, T., Oki, T., Miyagawa, T., Amanuma, H. Genes Dev. (1994) [Pubmed]
  3. The zebrafish spiel-ohne-grenzen (spg) gene encodes the POU domain protein Pou2 related to mammalian Oct4 and is essential for formation of the midbrain and hindbrain, and for pre-gastrula morphogenesis. Burgess, S., Reim, G., Chen, W., Hopkins, N., Brand, M. Development (2002) [Pubmed]
  4. Complex expression of the zp-50 pou gene in the embryonic zebrafish brain is altered by overexpression of sonic hedgehog. Hauptmann, G., Gerster, T. Development (1996) [Pubmed]
  5. Zebrafish pit1 mutants lack three pituitary cell types and develop severe dwarfism. Nica, G., Herzog, W., Sonntag, C., Hammerschmidt, M. Mol. Endocrinol. (2004) [Pubmed]
  6. A POU-domain gene of zebrafish, ZFPOU1, specifically expressed in the developing neural tissues. Matsuzaki, T., Amanuma, H., Takeda, H. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  7. The POU domain protein spg (pou2/Oct4) is essential for endoderm formation in cooperation with the HMG domain protein casanova. Reim, G., Mizoguchi, T., Stainier, D.Y., Kikuchi, Y., Brand, M. Dev. Cell (2004) [Pubmed]
  8. Zebrafish pou[c]: a divergent POU family gene ubiquitously expressed during embryogenesis. Johansen, T., Moens, U., Holm, T., Fjose, A., Krauss, S. Nucleic Acids Res. (1993) [Pubmed]
  9. Developmental expression of the POU domain transcription factor Brn-3b (Pou4f2) in the lateral line and visual system of zebrafish. DeCarvalho, A.C., Cappendijk, S.L., Fadool, J.M. Dev. Dyn. (2004) [Pubmed]
  10. Developmental expression of class III and IV POU domain genes in the zebrafish. Sampath, K., Stuart, G.W. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
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