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Gene Review

POU3F1  -  POU class 3 homeobox 1

Homo sapiens

Synonyms: OCT6, OTF-6, OTF6, Oct-6, Octamer-binding protein 6, ...
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Disease relevance of POU3F1


High impact information on POU3F1

  • The primary structure of SCIP, a POU protein expressed by developing Schwann cells of the peripheral nervous system, was deduced and SCIP activity was studied [4].
  • Both in normal development and in response to nerve transection, SCIP expression was transiently activated only during the period of rapid cell division that separates the premyelinating and myelinating phases of Schwann cell differentiation [4].
  • When fused to a heterologous DNA-binding domain, this SCIP domain is a potent transactivator in Schwann cells but is inactive in three heterologous cell types [5].
  • The primary structure of the SCIP amino-terminal domain is novel but contains a polymorphic string of alanine residues similar to those found in several other transcription factors [5].
  • This differential behavior was due to differences in the amino-terminal regions of the proteins, as evident from chimeras between Tst-1/Oct6/SCIP and Brn-1 [6].

Biological context of POU3F1


Anatomical context of POU3F1

  • Oct-6: a regulator of keratinocyte gene expression in stratified squamous epithelia [8].
  • By in situ hybridization, Oct-6 mRNA was detected not only in epidermis but also a variety of other stratified squamous epithelia and with greater signals than testis, the tissue in which this POU protein was originally discovered [8].
  • In tst-1/scip/oct-6-null sciatic nerves, Schwann cells are transiently arrested at the "promyelinating" stage, when they have a one-to-one relationship with an axon but before they have elaborated a myelin sheath [9].
  • Oct6 was present in cytoplasm of Schwann cells associated with normal-appearing myelinated nerve fibers, but not in nuclei [2].
  • Examination of ova with three pronuclei and 1-cell through blastocyst stage embryos revealed that OCT4 mRNA was continuously expressed between the time of fertilization and 10+ cell stages, whereas OCT6 mRNA expression was not observed until the 10+ cell stage [10].

Associations of POU3F1 with chemical compounds

  • We further showed mRNA expression of ATB0+ (an amino acid transporter with a Na+/Cl(-)-dependent carnitine transport activity), and Fly-like putative transporter 2/OCT6 (a splice variant of carnitine transporter 2: a testis-specific Na+-dependent carnitine transporter) [11].
  • OTE reduced the rate of acid production by mutans streptococci accompanied with the retardation of growth rate of mutans streptococci, while the action by chromatographically isolated oolong tea polyphenol (OTF6) was weak [12].

Other interactions of POU3F1


Analytical, diagnostic and therapeutic context of POU3F1


  1. Functional interaction between the POU domain protein Tst-1/Oct-6 and the high-mobility-group protein HMG-I/Y. Leger, H., Sock, E., Renner, K., Grummt, F., Wegner, M. Mol. Cell. Biol. (1995) [Pubmed]
  2. Oct6, a transcription factor controlling myelination, is a marker for active nerve regeneration in peripheral neuropathies. Kawasaki, T., Oka, N., Tachibana, H., Akiguchi, I., Shibasaki, H. Acta Neuropathol. (2003) [Pubmed]
  3. Problems in the health management of persons with spinal cord injury. Imai, K., Kadowaki, T., Aizawa, Y., Fukutomi, K. Journal of clinical epidemiology. (1996) [Pubmed]
  4. Expression and activity of the POU transcription factor SCIP. Monuki, E.S., Kuhn, R., Weinmaster, G., Trapp, B.D., Lemke, G. Science (1990) [Pubmed]
  5. Cell-specific action and mutable structure of a transcription factor effector domain. Monuki, E.S., Kuhn, R., Lemke, G. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  6. The J domain of papovaviral large tumor antigen is required for synergistic interaction with the POU-domain protein Tst-1/Oct6/SCIP. Sock, E., Enderich, J., Wegner, M. Mol. Cell. Biol. (1999) [Pubmed]
  7. Human class III POU genes, POU3F1 and POU3F3, map to chromosomes 1p34.1 and 3p14.2. Sumiyama, K., Washio-Watanabe, K., Ono, T., Yoshida, M.C., Hayakawa, T., Ueda, S. Mamm. Genome (1998) [Pubmed]
  8. Oct-6: a regulator of keratinocyte gene expression in stratified squamous epithelia. Faus, I., Hsu, H.J., Fuchs, E. Mol. Cell. Biol. (1994) [Pubmed]
  9. Promyelinating Schwann cells express Tst-1/SCIP/Oct-6. Arroyo, E.J., Bermingham, J.R., Rosenfeld, M.G., Scherer, S.S. J. Neurosci. (1998) [Pubmed]
  10. Expression of transcription regulating genes in human preimplantation embryos. Abdel-Rahman, B., Fiddler, M., Rappolee, D., Pergament, E. Hum. Reprod. (1995) [Pubmed]
  11. Carnitine/xenobiotics transporters in the human mammary gland epithelia, MCF12A. Kwok, B., Yamauchi, A., Rajesan, R., Chan, L., Dhillon, U., Gao, W., Xu, H., Wang, B., Takahashi, S., Semple, J., Tamai, I., Nezu, J., Tsuji, A., Harper, P., Ito, S. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2006) [Pubmed]
  12. Inhibitory effects of oolong tea extract on caries-inducing properties of mutans streptococci. Matsumoto, M., Minami, T., Sasaki, H., Sobue, S., Hamada, S., Ooshima, T. Caries Res. (1999) [Pubmed]
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