High impact information on Pou3f3

• Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons [1].
• POU homeodomain proteins Brn-1 and Brn-2 are coexpressed in the developing neocortex, both in the late precursor cells and in the migrating neurons [1].

Biological context of Pou3f3

• Other POU-III genes, such as Brn-1 and Brn-2, did not exhibit this upregulation [2].
• Here, we have replaced Oct-6 expression in the mouse with expression of the class III POU domain protein Brn-1 [3].
• A hybrid POU/Pbx binding site is recognized in vitro by Pbx-1, Brn-1 and Brn-2 [4].
• Two of the four DNA sequence elements are shown to interact with the neural specific Pou-domain class III transcription factors Brn1 and Brn2 [5].

Anatomical context of Pou3f3

• Although this protein is not normally expressed in Schwann cells, Brn-1 was capable of fully replacing Oct-6 [3].
• Moreover, ectopic expression of a dominant-negative Brn1 protein in chick embryos implicated Brn1 in Fgf8 gene regulation [6].
• In this report, we identify a component of the regulation of Cdk5-mediated cortical lamination by genetic analysis of the roles of the class III POU domain transcription factors, Brn-1 and Brn-2, expressed during the development of the forebrain and coexpressed in most layer II-V cortical neurons [7].

Associations of Pou3f3 with chemical compounds

• These results suggest that Brn1 is essential for both the development and function of the nephron in the kidney [8].

Regulatory relationships of Pou3f3

• Brn-1 efficiently induced Krox-20 expression as a prerequisite for myelination [3].

Other interactions of Pou3f3

• Onset and extent of myelination were also indistinguishable from that of the wild type in mice that carried only Brn-1 instead of Oct-6 alleles [3].
• In transfection, addition of either Oct-1 or Brn-1 reduced AR activation, regardless of the presence of an octamer-like sequence in the enhancer, suggesting interference was indirect [9].

References