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Gene Review

Pou3f3  -  POU domain, class 3, transcription factor 3

Mus musculus

Synonyms: Brain-1, Brain-specific homeobox/POU domain protein 1, Brn-1, Brn1, OTF-8, ...
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High impact information on Pou3f3

  • Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons [1].
  • POU homeodomain proteins Brn-1 and Brn-2 are coexpressed in the developing neocortex, both in the late precursor cells and in the migrating neurons [1].

Biological context of Pou3f3


Anatomical context of Pou3f3

  • Although this protein is not normally expressed in Schwann cells, Brn-1 was capable of fully replacing Oct-6 [3].
  • Moreover, ectopic expression of a dominant-negative Brn1 protein in chick embryos implicated Brn1 in Fgf8 gene regulation [6].
  • In this report, we identify a component of the regulation of Cdk5-mediated cortical lamination by genetic analysis of the roles of the class III POU domain transcription factors, Brn-1 and Brn-2, expressed during the development of the forebrain and coexpressed in most layer II-V cortical neurons [7].

Associations of Pou3f3 with chemical compounds

  • These results suggest that Brn1 is essential for both the development and function of the nephron in the kidney [8].

Regulatory relationships of Pou3f3

  • Brn-1 efficiently induced Krox-20 expression as a prerequisite for myelination [3].

Other interactions of Pou3f3

  • Onset and extent of myelination were also indistinguishable from that of the wild type in mice that carried only Brn-1 instead of Oct-6 alleles [3].
  • In transfection, addition of either Oct-1 or Brn-1 reduced AR activation, regardless of the presence of an octamer-like sequence in the enhancer, suggesting interference was indirect [9].


  1. Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons. Sugitani, Y., Nakai, S., Minowa, O., Nishi, M., Jishage, K., Kawano, H., Mori, K., Ogawa, M., Noda, T. Genes Dev. (2002) [Pubmed]
  2. A role for the POU-III transcription factor Brn-4 in the regulation of striatal neuron precursor differentiation. Shimazaki, T., Arsenijevic, Y., Ryan, A.K., Rosenfeld, M.G., Weiss, S. EMBO J. (1999) [Pubmed]
  3. The class III POU domain protein Brn-1 can fully replace the related Oct-6 during schwann cell development and myelination. Friedrich, R.P., Schlierf, B., Tamm, E.R., Bösl, M.R., Wegner, M. Mol. Cell. Biol. (2005) [Pubmed]
  4. POU transcription factors control expression of CNS stem cell-specific genes. Josephson, R., Müller, T., Pickel, J., Okabe, S., Reynolds, K., Turner, P.A., Zimmer, A., McKay, R.D. Development (1998) [Pubmed]
  5. Hox/Pbx and Brn binding sites mediate Pax3 expression in vitro and in vivo. Pruitt, S.C., Bussman, A., Maslov, A.Y., Natoli, T.A., Heinaman, R. Gene Expr. Patterns (2004) [Pubmed]
  6. Identification of Pax2-regulated genes by expression profiling of the mid-hindbrain organizer region. Bouchard, M., Grote, D., Craven, S.E., Sun, Q., Steinlein, P., Busslinger, M. Development (2005) [Pubmed]
  7. Transcriptional regulation of cortical neuron migration by POU domain factors. McEvilly, R.J., de Diaz, M.O., Schonemann, M.D., Hooshmand, F., Rosenfeld, M.G. Science (2002) [Pubmed]
  8. Crucial roles of Brn1 in distal tubule formation and function in mouse kidney. Nakai, S., Sugitani, Y., Sato, H., Ito, S., Miura, Y., Ogawa, M., Nishi, M., Jishage, K., Minowa, O., Noda, T. Development (2003) [Pubmed]
  9. Androgen receptor interactions with Oct-1 and Brn-1 are physically and functionally distinct. González, M.I., Tovaglieri, A., Robins, D.M. Mol. Cell. Endocrinol. (2002) [Pubmed]
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