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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

pou3f3a  -  POU class 3 homeobox 3a

Danio rerio

Synonyms: BRN-1.1, Brain-1.1, Brain-specific homeobox/POU domain protein 1.1, Class III POU domain protein taichi, POU domain protein 12, ...
 
 
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High impact information on pou12

  • In this study, we examined the developmental expression patterns of the Brn-1- and Brn-2-related zp-12, zp-23 and zp-47 genes by means of whole-mount in situ hybridization [1].
  • During development, as differentiation occurs, the expression of tai-ji is downregulated in the notochord, muscle, nervous system and dorsal fin [2].
  • We propose that the majority of the tai-ji-expressing cells are neural stem or progenitor cell populations that may represent the cellular basis for continuous growth in the adult nervous system [2].
  • Similarly, tai-ji is expressed in the human neuronal precursor cell, hNT2, but is downregulated upon differentiation with retinoic acid [2].
  • In the adult zebrafish nervous system, tai-ji persists in germinal zones, including cells in the germinal zone of the retina, the basal cells of the olfactory epithelium and cells of the subependymal zones in the optic tectum and telencephalon [2].

References

  1. Combinatorial expression of zebrafish Brn-1- and Brn-2-related POU genes in the embryonic brain, pronephric primordium, and pharyngeal arches. Hauptmann, G., Gerster, T. Dev. Dyn. (2000) [Pubmed]
  2. Progenitor cells in the adult zebrafish nervous system express a Brn-1-related POU gene, tai-ji. Huang, S., Sato, S. Mech. Dev. (1998) [Pubmed]
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