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Gene Review:

GDPD2 - glycerophosphodiester phosphodiesterase...

Homo sapiens

Synonyms: FLJ20207, GDE3, Glycerophosphodiester phosphodiesterase 3, Glycerophosphodiester phosphodiesterase domain-containing protein 2, Glycerophosphoinositol inositolphosphodiesterase GDPD2, ...

Yanaka, N. et al., Nogusa, Y. et al.

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High impact information on GDPD2

To identify a role for GDE3 in osteoblast differentiation, MC3T3-E1 cells stably expressing the full-length protein were constructed [1].
Immunofluorescence staining with GDE3 antibody and phalloidin in MC3T3-E1 cells indicated that endogenous GDE3 might be co-localized with the actin cytoskeleton [1].
In amino acid sequences, GDE2 and GDE6 are 43.7% and 34.3% identical to GDE3, respectively [2].
Although GDE3 mRNA is highly expressed in bone tissue and spleen, GDE2 mRNA was expressed in a variety of mouse tissues including lung and heart, while the GDE6 transcript was particularly abundant in spermatocytes of mouse testis [2].

Analytical, diagnostic and therapeutic context of GDPD2

Northern blot analysis revealed that GDE3 was also expressed in spleen as well as primary calvarial osteoblasts and femur [1].

References

Novel membrane protein containing glycerophosphodiester phosphodiesterase motif is transiently expressed during osteoblast differentiation. Yanaka, N., Imai, Y., Kawai, E., Akatsuka, H., Wakimoto, K., Nogusa, Y., Kato, N., Chiba, H., Kotani, E., Omori, K., Sakurai, N. J. Biol. Chem. (2003) [Pubmed]
Isolation and characterization of two serpentine membrane proteins containing glycerophosphodiester phosphodiesterase, GDE2 and GDE6. Nogusa, Y., Fujioka, Y., Komatsu, R., Kato, N., Yanaka, N. Gene (2004) [Pubmed]

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GDPD2	Macaca mulatta
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gdpd2	Xenopus (Silurana) tropicalis

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