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Gene Review

prickle1  -  prickle homolog 1

Xenopus (Silurana) tropicalis

Synonyms: Prickle-b, XPk, prickle, rilp
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Disease relevance of prickle1

  • We report that perturbing expression of Xenopus PCP genes, Strabismus (Xstbm), Frizzled (Xfz7), and Prickle (Xpk), disrupts radially polarized fibronectin fibril assembly on mesodermal tissue surfaces, mediolaterally polarized motility, and intercalation [1].

High impact information on prickle1


  1. Planar cell polarity genes regulate polarized extracellular matrix deposition during frog gastrulation. Goto, T., Davidson, L., Asashima, M., Keller, R. Curr. Biol. (2005) [Pubmed]
  2. Cloning and expression of Xenopus Prickle, an orthologue of a Drosophila planar cell polarity gene. Wallingford, J.B., Goto, T., Keller, R., Harland, R.M. Mech. Dev. (2002) [Pubmed]
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