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Gene Review

Prickle1  -  prickle homolog 1 (Drosophila)

Rattus norvegicus

Synonyms: Prickle-like protein 1, REST/NRSF-interacting LIM domain protein 1, Rilp
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Disease relevance of Prickle1


High impact information on Prickle1

  • In the normal rat palatal epithelium, a weak cytoplasmic staining of ASK1 was observed in keratinocytes of the prickle cell layer [2].
  • Reactive cells were present throughout the depth of the epithelium, but noticeably more concentrated in the basal and superficial prickle cell layers [3].
  • ASA reduced, in rat fetuses, the ethanol deleterious effects on nuclear size in the epithelial prickle cell of the lingual mucosa [4].
  • Skin injection with pCAGGS-lacZ showed lacZ gene expression in the upper most cell layers (horny, granular, and prickle cell layers) of the epidermis on day 1 and in the subcutaneous muscle layer on day 7 after the pCAGGS-lacZ transfer [5].


  1. The effects of feeding a zinc-deficient diet on taste acuity and tongue epithelium in rats. Catalanotto, F.A., Nanda, R. J. Oral Pathol. (1977) [Pubmed]
  2. Evidence for apoptosis signal-regulating kinase 1 in the regenerating palatal epithelium upon acute injury. Funato, N., Moriyama, K., Saitoh, M., Baba, Y., Ichijo, H., Kuroda, T. Lab. Invest. (1998) [Pubmed]
  3. The distribution of carbonic anhydrase II in human, pig and rat oesophageal epithelium. Christie, K.N., Thomson, C. Histochem. J. (2000) [Pubmed]
  4. Teratogenic Effects of the Interaction Acetylsalicylic Acid (ASA) and Ethanol: Morphologic and Morphometric Evaluation of the Lingual Epithelium in Rat Fetuses. Marinho, S.A., Sala, M.A., Lopes, R.A., de Moraes Grisi, M.F., Novaes, A.B., de Souza, S.L., Taba, M. Anatomia, histologia, embryologia (2007) [Pubmed]
  5. Epidermis-targeted gene transfer using in vivo electroporation. Maruyama, H., Miyazaki, J., Gejyo, F. Methods Mol. Biol. (2005) [Pubmed]
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