Disease relevance of Prickle1

• The 24K protein was observed to be located primarily in the parabasal or "prickle cell layer" of normal cervical tissue (6 of 7 normal cervical tissue specimens tested were positive for 24K protein. Specimens were obtained from surgery for nonneoplastic causes) and in all cases (12 of 12) of dysplasia and carcinoma in situ [1].

High impact information on Prickle1

• Vangl1 and Prickle1 had expression canvases different from each other and from other candidates, indicating unrelated function [2].
• The Drosophila melanogaster gene prickle-spiny-legs (pk) functions in an intercellular feedback loop that is central to the establishment of planar cell polarity in the eye and epidermis of the fly, by modulating Frizzled-Disheveled signalling [3].
• We report that the putative PCP protein Prickle-like 2 (Pk2) is distributed in crescents on the medial sides of vestibular epithelial cells before the morphological polarization of hair cells [4].
• The fluorescence was apparent only in the prickle cell layer, not at the basement membrane region nor in the connective tissue [5].

References