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Gene Review

Prickle1  -  prickle homolog 1 (Drosophila)

Mus musculus

Synonyms: 1110058P22Rik, AW215793, Prickle, Prickle-like protein 1, b2b019Clo, ...
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Disease relevance of Prickle1

  • The 24K protein was observed to be located primarily in the parabasal or "prickle cell layer" of normal cervical tissue (6 of 7 normal cervical tissue specimens tested were positive for 24K protein. Specimens were obtained from surgery for nonneoplastic causes) and in all cases (12 of 12) of dysplasia and carcinoma in situ [1].

High impact information on Prickle1


  1. A new marker of maturation in the cervix: the estrogen-regulated 24K protein. Dressler, L.G., Ramzy, I., Sledge, G.W., McGuire, W.L. Obstetrics and gynecology. (1986) [Pubmed]
  2. Expression of planar cell polarity genes during development of the mouse CNS. Tissir, F., Goffinet, A.M. Eur. J. Neurosci. (2006) [Pubmed]
  3. Embryonic expression of three mouse genes with homology to the Drosophila melanogaster prickle gene. Bekman, E., Henrique, D. Mech. Dev. (2002) [Pubmed]
  4. Asymmetric distribution of Prickle-like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear. Deans, M.R., Antic, D., Suyama, K., Scott, M.P., Axelrod, J.D., Goodrich, L.V. J. Neurosci. (2007) [Pubmed]
  5. A method for producing monoclonal antibodies to human oral epithelial cells by the hybridoma technique. Gazi, M.I. Journal de biologie buccale. (1986) [Pubmed]
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