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Gene Review

PRICKLE1  -  prickle homolog 1 (Drosophila)

Homo sapiens

Synonyms: EPM1B, FLJ31937, Prickle-like protein 1, REST/NRSF-interacting LIM domain protein 1, RILP
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Disease relevance of PRICKLE1


High impact information on PRICKLE1

  • Clinicopathologic analysis showed that underexpression of Prickle-1 was significantly associated with overexpression of Dvl3, beta-catenin accumulation (P = .023), and larger tumor size (P = .030) [1].
  • Facial cell soma migration defects were associated with the coordinate downregulation of multiple components of the planar cell polarity pathway including Fzd7, Wnt11, Prickle1, Vang1 and Vang2 [6].
  • A recent study shows that, in ascidians, the planar cell polarity gene prickle regulates sequential establishment of cell polarity during two phases of notochord morphogenesis [7].
  • E-cadherin was found throughout the epithelium but was weakly expressed at the basal aspect of the basal cells layer and showed strong positivity in the prickle cell and squamous cell layers [8].
  • By using an antibody raised in rabbits against the N-terminal portion of the molecule, the polypeptide may be demonstrated in cells of the prickle cell layer of normal skin and in the cells of hair follicles [9].

Chemical compound and disease context of PRICKLE1


Biological context of PRICKLE1


Anatomical context of PRICKLE1


Associations of PRICKLE1 with chemical compounds


Regulatory relationships of PRICKLE1


Other interactions of PRICKLE1

  • Enforced expression of Prickle-1 significantly reduced the Wnt/beta-catenin activity and tumorigenic properties of HCC cells [1].
  • RUNX3 expression was shown in prickle and functional cell layer cells in normal esophageal mucosa [23].
  • METHODS AND RESULTS: In the normal esophageal mucosa, CD55 predominantly stained on the cell membrane of squamous epithelium in the superficial and prickle cell layers, whereas CD46 most intensely stained on the cell membrane in the basal and parabasal cell layers [24].
  • RESULTS: In the cholesteatoma epithelium specimens, cdk2 and cdk4 were observed to be expressed in the basal and parabasal layers and in the upper layer (prickle layer and granular layer) [25].
  • In normal epidermis, the largest proportion of PCNA- and Ki-67-positive cells was observed in the basal cell layer, with the amounts decreasing through the suprabasal cell layer towards the prickle cell layer [26].

Analytical, diagnostic and therapeutic context of PRICKLE1


  1. Prickle-1 Negatively Regulates Wnt/beta-Catenin Pathway by Promoting Dishevelled Ubiquitination/Degradation in Liver Cancer. Chan, D.W., Chan, C.Y., Yam, J.W., Ching, Y.P., Ng, I.O. Gastroenterology (2006) [Pubmed]
  2. Hairy leukoplakia--a histological study. Southam, J.C., Felix, D.H., Wray, D., Cubie, H.A. Histopathology (1991) [Pubmed]
  3. Intraepithelial atypical lymphocytes in oral lesions of Behçet's syndrome. Honma, T., Saito, T., Fujioka, Y. Archives of dermatology. (1981) [Pubmed]
  4. Observations on the antibody rsponses in molluscum contagiosum. Shirodaria, P.V., Matthews, R.S. Br. J. Dermatol. (1977) [Pubmed]
  5. Immunologic detection of condylomata acuminata-specific antigens. Dunn, J., Weinstein, L., Droegemueller, W., Meinke, W. Obstetrics and gynecology. (1981) [Pubmed]
  6. T-Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migration. Song, M.R., Shirasaki, R., Cai, C.L., Ruiz, E.C., Evans, S.M., Lee, S.K., Pfaff, S.L. Development (2006) [Pubmed]
  7. Notochord morphogenesis: a prickly subject for ascidians. Tada, M. Curr. Biol. (2005) [Pubmed]
  8. Cell adhesion molecules in oesophageal epithelium. Dobson, H., Pignatelli, M., Hopwood, D., D'Arrigo, C. Gut (1994) [Pubmed]
  9. Expression of parathyroid hormone related protein in normal skin and in tumours of skin and skin appendages. Hayman, J.A., Danks, J.A., Ebeling, P.R., Moseley, J.M., Kemp, B.E., Martin, T.J. J. Pathol. (1989) [Pubmed]
  10. Cellular kinetics and lectin distribution in hamster buccal carcinomas. Nishikawa, T., Wada, S., Wato, M., Tsutsui, J., Nishimura, Y., Matsuoka, K., Okano, H., Tanaka, A. J. Oral Pathol. Med. (1994) [Pubmed]
  11. Cyclosporin-induced gingival hyperplasia: an ultrastructural study of the oral epithelial prickle cells. Belazi, M., Thomopoulos, G.N., Markopoulos, A.K., Papanayotou, P. J. Submicrosc. Cytol. Pathol. (1993) [Pubmed]
  12. Radiation hybrid mapping of 18 positional and physiological candidate genes for arthrogryposis multiplex congenita on porcine chromosome 5. Genini, S., Nguyen, T.T., Malek, M., Talbot, R., Gebert, S., Rohrer, G., Nonneman, D., Stranzinger, G., Vögeli, P. Anim. Genet. (2006) [Pubmed]
  13. Ascidian prickle regulates both mediolateral and anterior-posterior cell polarity of notochord cells. Jiang, D., Munro, E.M., Smith, W.C. Curr. Biol. (2005) [Pubmed]
  14. Short communication: expression of human endogenous retrovirus-R gene links to differentiation of squamous cells. Otsuka, N., Miyatake, Y., Ishizu, A., Tanaka, S., Yamamoto, Y., Ikeda, H., Yoshiki, T. AIDS Res. Hum. Retroviruses (2006) [Pubmed]
  15. Possible role of apoptotic cells of the oral epithelium in the pathogenesis of aphthous ulceration. Honma, T., Saito, T., Fujioka, Y. Oral Surg. Oral Med. Oral Pathol. (1985) [Pubmed]
  16. Asymmetric distribution of Prickle-like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear. Deans, M.R., Antic, D., Suyama, K., Scott, M.P., Axelrod, J.D., Goodrich, L.V. J. Neurosci. (2007) [Pubmed]
  17. Cellular junctions in human oesophageal epithelium. Logan, K.R., Hopwood, D., Milne, G. J. Pathol. (1978) [Pubmed]
  18. Quantitation and localization of cellular retinol-binding protein in squamous-cell carcinomas of the cervix uteri and of the oral cavity. Wahlberg, P., Fex, G., Biörklund, A., Tropé, C., Willén, R. Int. J. Cancer (1988) [Pubmed]
  19. Histochemical studies of mucosubstances and lipids in normal human oesophageal epithelium. Hopwood, D., Logan, K.R., Coghill, G., Bouchier, I.A. Histochem. J. (1977) [Pubmed]
  20. Biological functions of keratinocyte cholinergic receptors. Grando, S.A. J. Investig. Dermatol. Symp. Proc. (1997) [Pubmed]
  21. CHILD syndrome: analysis of abnormal keratinization and ultrastructure. Hashimoto, K., Topper, S., Sharata, H., Edwards, M. Pediatric dermatology. (1995) [Pubmed]
  22. Expression profile of immune-associated genes in nasal polyps. Wang, X., Dong, Z., Zhu, D.D., Guan, B. Ann. Otol. Rhinol. Laryngol. (2006) [Pubmed]
  23. Expression of RUNX3 Protein in Human Esophageal Mucosa and Squamous Cell Carcinoma. Hiramatsu, T., Osaki, M., Ito, Y., Tanji, Y., Tokuyasu, N., Ito, H. Pathobiology (2005) [Pubmed]
  24. Complement regulatory proteins in normal human esophagus and esophageal squamous cell carcinoma. Shimo, K., Mizuno, M., Nasu, J., Hiraoka, S., Makidono, C., Okazaki, H., Yamamoto, K., Okada, H., Fujita, T., Shiratori, Y. J. Gastroenterol. Hepatol. (2004) [Pubmed]
  25. Roles of cytokines and cell cycle regulating substances in proliferation of cholesteatoma epithelium. Tanaka, Y., Kojima, H., Miyazaki, H., Koga, T., Moriyama, H. Laryngoscope (1999) [Pubmed]
  26. Histopathological assessment of localized proliferation in cases of Bowen's disease using immunostaining and a laser cytometer. Murakami, M., Hashimoto, Y., Tsukinoki, K., Matsunaga, K., Mizoguchi, Y., Horibe, Y., Tashiro, K., Watanabe, Y., Kasahara, M. Arch. Dermatol. Res. (1998) [Pubmed]
  27. Neural correlates of prickle sensation: a percept-related fMRI study. Davis, K.D., Pope, G.E., Crawley, A.P., Mikulis, D.J. Nat. Neurosci. (2002) [Pubmed]
  28. Cold-induced pain and prickle in the glabrous and hairy skin. Davis, K.D. Pain (1998) [Pubmed]
  29. Transcutaneous electrical stimulation and the sensation of prickle. Garnsworthy, R.K., Gully, R.L., Kenins, P., Westerman, R.A. J. Neurophysiol. (1988) [Pubmed]
  30. Gene expression of differentiation-specific keratins (4/13 and 1/10) in normal human buccal mucosa. Bloor, B.K., Su, L., Shirlaw, P.J., Morgan, P.R. Lab. Invest. (1998) [Pubmed]
  31. Painful pricks and prickle pains: is there a relation between children's ratings of venipuncture pain and parental assessments of usual reaction to other pains? Goodenough, T.B., Perrott, D.A., Champion, G.D., Thomas, W. The Clinical journal of pain. (2000) [Pubmed]
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