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Gene Review

PAK1IP1  -  PAK1 interacting protein 1

Homo sapiens

Synonyms: FLJ20624, MAK11, PAK/PLC-interacting protein 1, PAK1-interacting protein 1, PIP1, ...
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High impact information on PAK1IP1

  • By performing a yeast two-hybrid screen of a mammary gland library, we identified cysteine-rich inhibitor of Pak1 (CRIPak) as a novel Pak1-interacting protein [1].
  • Using yeast two-hybrid screening, we identified SHARP, one of the Notch signaling components, as a Pak1-interacting protein [2].
  • They possess six membrane-spanning domains, an NPA repeat, overall high sequence homologies and characteristic C- and N-terminal hallmark motifs which allowed assignment of OsPIP1a to the PIP1 subfamily and of OsPIP2a to the PIP2 subfamily [3].
  • Protein abundance was examined using antibodies against PIP1 and PIP2 aquaporins [4].
  • On the other hand, ABA raised both root PIP1 protein abundance and L. * Conclusions The rise of PvPIP2;1 gene expression and PIP1 protein abundance in the leaves of P. vulgaris plants subjected to drought was correlated with a decline in the transpiration rate [4].

Biological context of PAK1IP1

  • The three treatments caused a decline in the transpiration rate and raised PVPIP2;1 gene expression and PIP1 protein abundance in the leaves [4].

Anatomical context of PAK1IP1

  • KEY RESULTS: The plasma membrane aquaporins PIP1 and PIP2 were expressed more in IC-cells and endodermis than in pericycle and infected cells [5].


  1. CRIPak, a novel endogenous Pak1 inhibitor. Talukder, A.H., Meng, Q., Kumar, R. Oncogene (2006) [Pubmed]
  2. An essential role of Pak1 phosphorylation of SHARP in Notch signaling. Vadlamudi, R.K., Manavathi, B., Singh, R.R., Nguyen, D., Li, F., Kumar, R. Oncogene (2005) [Pubmed]
  3. Expression of two PIP genes in rapidly growing internodes of rice is not primarily controlled by meristem activity or cell expansion. Malz, S., Sauter, M. Plant Mol. Biol. (1999) [Pubmed]
  4. Drought, Abscisic Acid and Transpiration Rate Effects on the Regulation of PIP Aquaporin Gene Expression and Abundance in Phaseolus vulgaris Plants. Aroca, R., Ferrante, A., Vernieri, P., Chrispeels, M.J. Ann. Bot. (2006) [Pubmed]
  5. The distribution of aquaporin subtypes (PIP1, PIP2 and gamma-TIP) is tissue dependent in soybean (Glycine max) root nodules. Fleurat-Lessard, P., Michonneau, P., Maeshima, M., Drevon, J.J., Serraj, R. Ann. Bot. (2005) [Pubmed]
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