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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DET1  -  de-etiolated homolog 1 (Arabidopsis)

Homo sapiens

Synonyms: DET1 homolog, De-etiolated-1 homolog, FLJ10103
 
 
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High impact information on DET1

  • Fruit-specific RNAi-mediated suppression of DET1 enhances carotenoid and flavonoid content in tomatoes [1].
  • We attempted to increase tomato fruit nutritional value by suppressing an endogenous photomorphogenesis regulatory gene, DET1, using fruit-specific promoters combined with RNA interference (RNAi) technology [1].
  • The hp-2(j) mutant is caused by a mutation in the tomato homolog of the DEETIOLATED1 (DET1) gene, involved in the signal transduction cascade of light perception and morphogenesis [2].
  • A linkage analysis, carried out in a F(2) population, shows a very strong linkage association between the DET1 locus of dg mutant plants and the photomorphogenic response of the seedlings, measured as hypocotyl length (12 < LOD Score < 13, R(2) = 51.1%) [2].
  • This transversion results in a conserved Asparagine(34)-to-Isoleucine(34) amino-acid substitution, and eliminates a recognition site for the AclI restriction endonuclease, present in the wild-type and in the other currently known tomato mutants at the DET1 locus [2].
 

Analytical, diagnostic and therapeutic context of DET1

  • Sequence analysis of the DET1 gene was carried out in dg mutants representing two different lines, and revealed a single A-to-T base transversion in the second exon of the DET1 gene in comparison with the normal wild-type sequence [2].

References

  1. Fruit-specific RNAi-mediated suppression of DET1 enhances carotenoid and flavonoid content in tomatoes. Davuluri, G.R., van Tuinen, A., Fraser, P.D., Manfredonia, A., Newman, R., Burgess, D., Brummell, D.A., King, S.R., Palys, J., Uhlig, J., Bramley, P.M., Pennings, H.M., Bowler, C. Nat. Biotechnol. (2005) [Pubmed]
  2. The tomato dark green mutation is a novel allele of the tomato homolog of the DEETIOLATED1 gene. Levin, I., Frankel, P., Gilboa, N., Tanny, S., Lalazar, A. Theor. Appl. Genet. (2003) [Pubmed]
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