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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PPP2R1A  -  protein phosphatase 2, regulatory subunit...

Homo sapiens

Synonyms: Medium tumor antigen-associated 61 kDa protein, PP2A subunit A isoform PR65-alpha, PP2A subunit A isoform R1-alpha, PP2A-Aalpha, PP2AAALPHA, ...
 
 
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Disease relevance of PPP2R1A

  • The PPP2R1A gene, encoding the alpha isoform of the heterotrimeric serine/threonine protein phosphatase 2A (PP2A), is located within the FWT2 candidate region and is altered in breast and lung carcinomas [1].
  • Here, we report the detection of mutations in breast, lung carcinomas and melanomas in the genes of both alpha (PPP2R1A) and beta isoforms [2].
 

High impact information on PPP2R1A

 

Analytical, diagnostic and therapeutic context of PPP2R1A

References

  1. Absence of PPP2R1A mutations in Wilms tumor. Ruteshouser, E.C., Ashworth, L.K., Huff, V. Oncogene (2001) [Pubmed]
  2. Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms. Calin, G.A., di Iasio, M.G., Caprini, E., Vorechovsky, I., Natali, P.G., Sozzi, G., Croce, C.M., Barbanti-Brodano, G., Russo, G., Negrini, M. Oncogene (2000) [Pubmed]
  3. Molecular cloning and sequence of cDNA encoding polyoma medium tumor antigen-associated 61-kDa protein. Walter, G., Ferre, F., Espiritu, O., Carbone-Wiley, A. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
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