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Gene Review

PPP2R1B  -  protein phosphatase 2, regulatory subunit...

Homo sapiens

Synonyms: PP2A subunit A isoform PR65-beta, PP2A subunit A isoform R1-beta, PP2A-Abeta, PR65B, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
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Disease relevance of PPP2R1B

  • Alterations of the PPP2R1B gene in human lung and colon cancer [1].
  • Absence of PPP2R1B gene alterations in primary ovarian cancers [2].
  • Alterations of the PPP2R1B gene located at 11q23 in human colorectal cancers [3].
  • The codon 90 Gly > Asp alteration may represent a non-pathological polymorphism and consequently the mutation frequency reported in lung cancers may have been overstated and the designation of PPP2R1B as a tumor suppressor gene should be regarded with caution [2].
  • Although the frequency of alterations is low, the inclusion of both isoforms of subunit A in the genes mutated in human cancer and the addition of breast cancer to the list of neoplasms in which PPP2R1B is altered, strengthen the potential role of PP2A in human tumorogenesis [4].

High impact information on PPP2R1B

  • Several independent studies indicate that multiple tumor-suppressor genes are found in this region, including the gene PPP2R1B at 11q23-24 (ref. 7). Linkage studies of NSCLC are precluded because no hereditary forms are known [5].
  • Sequencing of the PPP2R1B gene, located on human chromosome 11q22-24, revealed somatic alterations in 15% (5 out of 33) of primary lung tumors, 6% (4 out of 70) of lung tumor-derived cell lines, and 15% (2 out of 13) of primary colon tumors [1].
  • These findings suggested that both PPP2R1A and PPP2R1B may be tumor suppressor genes [6].
  • Varying proportions of alterations were detected, ranging from 6% in PPP2R1B to 39% in PIG8 [7].
  • Most of the mutations affecting PPP2R1B were exons deletions, suggesting abnormal splicing [4].

Chemical compound and disease context of PPP2R1B


Biological context of PPP2R1B


Associations of PPP2R1B with chemical compounds


Other interactions of PPP2R1B

  • One region is bracketed by markers D11S1647 and NCAM2 and contains the gene encoding the beta isoform of the A subunit of the human protein phosphatase 2A (PPP2R1B) [11].
  • Because the protein phosphatase 2 regulatory subunit A beta isoform gene (PPP2R1B) maps within the critical region of hereditary paraganglioma (PGL1) on chromosomal band 11q23, we characterized its genomic structure and evaluated it as a candidate gene for PGL1 [12].
  • We performed polymerase chain reaction-based single-strand conformation polymorphism and direct sequencing on six parathyroid hyperplasias and 12 adenomas to evaluate the role of PPP2R1B in the pathogenesis of parathyroid lesions [8].

Analytical, diagnostic and therapeutic context of PPP2R1B


  1. Alterations of the PPP2R1B gene in human lung and colon cancer. Wang, S.S., Esplin, E.D., Li, J.L., Huang, L., Gazdar, A., Minna, J., Evans, G.A. Science (1998) [Pubmed]
  2. Absence of PPP2R1B gene alterations in primary ovarian cancers. Campbell, I.G., Manolitsas, T. Oncogene (1999) [Pubmed]
  3. Alterations of the PPP2R1B gene located at 11q23 in human colorectal cancers. Takagi, Y., Futamura, M., Yamaguchi, K., Aoki, S., Takahashi, T., Saji, S. Gut (2000) [Pubmed]
  4. Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms. Calin, G.A., di Iasio, M.G., Caprini, E., Vorechovsky, I., Natali, P.G., Sozzi, G., Croce, C.M., Barbanti-Brodano, G., Russo, G., Negrini, M. Oncogene (2000) [Pubmed]
  5. TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer. Kuramochi, M., Fukuhara, H., Nobukuni, T., Kanbe, T., Maruyama, T., Ghosh, H.P., Pletcher, M., Isomura, M., Onizuka, M., Kitamura, T., Sekiya, T., Reeves, R.H., Murakami, Y. Nat. Genet. (2001) [Pubmed]
  6. Absence of PPP2R1A mutations in Wilms tumor. Ruteshouser, E.C., Ashworth, L.K., Huff, V. Oncogene (2001) [Pubmed]
  7. Candidate tumour suppressor genes at 11q23-q24 in breast cancer: evidence of alterations in PIG8, a gene involved in p53-induced apoptosis. Gentile, M., Ahnström, M., Schön, F., Wingren, S. Oncogene (2001) [Pubmed]
  8. Alterations in the suppressor gene PPP2R1B in parathyroid hyperplasias and adenomas. Hemmer, S., Wasenius, V.M., Haglund, C., Zhu, Y., Knuutila, S., Franssila, K., Joensuu, H. Cancer Genet. Cytogenet. (2002) [Pubmed]
  9. PPP2R1B gene alterations inhibit interaction of PP2A-Abeta and PP2A-C proteins in colorectal cancers. Tamaki, M., Goi, T., Hirono, Y., Katayama, K., Yamaguchi, A. Oncol. Rep. (2004) [Pubmed]
  10. The glycine 90 to aspartate alteration in the Abeta subunit of PP2A (PPP2R1B) associates with breast cancer and causes a deficit in protein function. Esplin, E.D., Ramos, P., Martinez, B., Tomlinson, G.E., Mumby, M.C., Evans, G.A. Genes Chromosomes Cancer (2006) [Pubmed]
  11. Refined mapping of two regions of loss of heterozygosity on chromosome band 11q23 in lung cancer. Wang, S.S., Virmani, A., Gazdar, A.F., Minna, J.D., Evans, G.A. Genes Chromosomes Cancer (1999) [Pubmed]
  12. Genomic organization and precise physical location of protein phosphatase 2A regulatory subunit A beta isoform gene on chromosome band 11q23. Baysal, B.E., Farr, J.E., Goss, J.R., Devlin, B., Richard, C.W. Gene (1998) [Pubmed]
  13. Altered response of a human squamous cell carcinoma cell line to 1, 25-dihydroxyvitamin D(3) after transfer of a normal chromosome 11. Merrihew, R.V., Cruickshank, R.D., Conway, K., Weissman, B.E. Exp. Cell Res. (2000) [Pubmed]
  14. PPP2R1B gene in chronic lymphocytic leukemias and mantle cell lymphomas. Zhu, Y., Loukola, A., Monni, O., Kuokkanen, K., Franssila, K., Elonen, E., Vilpo, J., Joensuu, H., Kere, J., Aaltonen, L., Knuutila, S. Leuk. Lymphoma (2001) [Pubmed]
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