Gene Review:
il10 - interleukin 10
Danio rerio
Synonyms:
SO:0000704, zgc:194510, zgc:194518
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High impact information on il10
- An open reading frame of 543 bp was found to encode a putative 180 amino acid protein with a signal peptide of 22 amino acids, which shares 29.7-80.9 % homology with amino acid sequences of other known IL-10 [1].
- Zebrafish IL-10 is located within a 2690 bp fragment and contains five exons and four introns, sharing the same organization with mammalian IL-10 genes [1].
- Using the ideal zebrafish model, further study of IL-10 characterization and function may provide insight on the understanding of the innate immune system [1].
- In this research, an important cytokine, interleukin-10 (IL-10) gene, has been identified and characterized from zebrafish (Danio rerio) genome database [1].
References
- Cloning, characterization and expression analysis of interleukin-10 from the zebrafish (Danio rerion). Zhang, D.C., Shao, Y.Q., Huang, Y.Q., Jiang, S.G. J. Biochem. Mol. Biol. (2005) [Pubmed]
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