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Gene Review

Il10  -  interleukin 10

Rattus norvegicus

Synonyms: CSIF, Cytokine synthesis inhibitory factor, IL-10, Il-10, Interleukin-10
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Disease relevance of Il10


Psychiatry related information on Il10


High impact information on Il10

  • The ligation of the complement C3 activation product iC3b to complement receptor type 3 (the iC3b receptor) on antigen-presenting cells resulted in the sequential production of transforming growth factor-beta2 and interleukin-10, which is essential for the induction of tolerance [9].
  • In vitro studies showed that within minutes catecholamines trigger the secretion of interleukin-10 from unstimulated monocytes through a beta-adrenoreceptor-mediated, cAMP/protein kinase A-dependent pathway [10].
  • Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury [10].
  • We found that in a rat model of acute brain injury, the beta-receptor antagonist propranolol prevented the increase of interleukin-10 plasma levels [10].
  • Associated phenotypic changes included upregulation of surface MHC II and B7 expression and IL-12 p35 mRNA, and downregulation of endocytosis, MHC II processing- associated genes, and IL-10 mRNA expression [11].

Chemical compound and disease context of Il10

  • CONCLUSION: Administration of IL-10 suppresses the TNF surge observed after severe hemorrhagic shock [12].
  • Daily SKF-525A pretreatment at a dose of 30 mg/kg, i.p., for 7 days 1 hour prior to KET and COC in combination effectively reversed the effects of this combination on body weight, organ/bodyweight ratios, histopathology, and serum IgM and IL-10 concentrations without affecting leukocytic counts [13].
  • Immunoneutralization of IL-10 through anti-IL-10 antibody administration to PBN/LPS-treated rats abrogated PBN's suppression of systemic nitric oxide (NO) formation, a surrogate marker for the severity of endotoxemia, indicating that IL-10 is a causal factor for the protection [14].
  • Interleukin-10 overexpression mediates phenyl-N-tert-butyl nitrone protection from endotoxemia [14].
  • Effects of ketamine and propofol on the ratio of interleukin-6 to interleukin-10 during endotoxemia in rats [15].

Biological context of Il10

  • Taken together, these data show that IL-10 inhibits mouse OC formation by acting directly on hemopoietic OC precursor, through a novel signal transduction and activation pathway [16].
  • IL-10 treatment also stimulated the binding of a protein in the BMM to an IL-10 response element, whereas no such activation was induced in osteoblastic cells [16].
  • Adenoviral vectors encoding rat IL-10 (AdIL-10), rat IL-4 (AdIL-4) or beta-galactosidase (AdlacZ) or without transgene (Addl324) were injected directly into rat hearts at the time of transplantation in order to test their potential to prolong heart allograft survival [1].
  • CONCLUSIONS: Kupffer cells after hepatectomy may aggravate endotoxin-induced liver injury via down-regulation of IL-10 production in the spleen [17].
  • These signaling events lead to the transcriptional activation of an early responsive gene and to the induction of expression of cytokines and a cytokine responsive protein such as interleukin-1beta, interleukin-6, interleukin-10 and suppressor of cytokine signalling-3, respectively [18].

Anatomical context of Il10


Associations of Il10 with chemical compounds


Enzymatic interactions of Il10

  • RGCs as well as native retina expressed functional IL-10R as determined by immunoblot analysis and by the ability of IL-10 to phosphorylate Stat-3 [26].

Regulatory relationships of Il10


Other interactions of Il10

  • In vivo suppression of NF-kappa B and preservation of I kappa B alpha by interleukin-10 and interleukin-13 [19].
  • Importantly, adenovirus-derived IL-10 modified the functional status of leukocytes by inducing a significant decrease in IFN-gamma production but significantly increased transforming-growth factor beta 1 (TGF-beta 1) expression within the grafts compared with those treated with Addl324 [1].
  • Furthermore, OX62(+) VDCs from infected rats primed naïve CD4(+) T-cell proliferation and release of cytokines, including gamma interferon, IL-2, IL-6, and IL-10, in response to staphylococcal enterotoxin B stimulation in vitro [31].
  • The decrease in the IL-10-to-TNF-alpha protein ratio in all coronary artery-ligated groups correlated with the depressed cardiac function [5].
  • Primary hepatocytes co-cultured with lipopolysaccharide-stimulated Kupffer cells or cultured with a combination of IL-1beta and IL-10 displayed reduced levels of phosphoenolpyruvate carboxykinase mRNA, protein and enzyme activity [2].

Analytical, diagnostic and therapeutic context of Il10


  1. Interleukin-10 produced by recombinant adenovirus prolongs survival of cardiac allografts in rats. David, A., Chétritt, J., Guillot, C., Tesson, L., Heslan, J.M., Cuturi, M.C., Soulillou, J.P., Anegon, I. Gene Ther. (2000) [Pubmed]
  2. Kupffer cell cytokines interleukin-1beta and interleukin-10 combine to inhibit phosphoenolpyruvate carboxykinase and gluconeogenesis in cultured hepatocytes. Yerkovich, S.T., Rigby, P.J., Fournier, P.A., Olynyk, J.K., Yeoh, G.C. Int. J. Biochem. Cell Biol. (2004) [Pubmed]
  3. Cytokines in relapsing experimental autoimmune encephalomyelitis in DA rats: persistent mRNA expression of proinflammatory cytokines and absent expression of interleukin-10 and transforming growth factor-beta. Issazadeh, S., Lorentzen, J.C., Mustafa, M.I., Höjeberg, B., Müssener, A., Olsson, T. J. Neuroimmunol. (1996) [Pubmed]
  4. Sequential expression of mRNA for proinflammatory cytokines and interleukin-10 in the rat peripheral nervous system: comparison between immune-mediated demyelination and Wallerian degeneration. Gillen, C., Jander, S., Stoll, G. J. Neurosci. Res. (1998) [Pubmed]
  5. Significance of changes in TNF-alpha and IL-10 levels in the progression of heart failure subsequent to myocardial infarction. Kaur, K., Sharma, A.K., Singal, P.K. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
  6. Central injection of IL-10 antagonizes the behavioural effects of lipopolysaccharide in rats. Bluthé, R.M., Castanon, N., Pousset, F., Bristow, A., Ball, C., Lestage, J., Michaud, B., Kelley, K.W., Dantzer, R. Psychoneuroendocrinology (1999) [Pubmed]
  7. Betamethasone Affects Cerebral Expressions of NF-{kappa}B and Cytokines that Correlate with Pain Behavior in a Rat Model of Neuropathy. Xie, W., Luo, S., Xuan, H., Chou, C., Song, G., Lv, R., Jin, Y., Li, W., Xu, J. Ann. Clin. Lab. Sci. (2006) [Pubmed]
  8. The effect of interleukin-10 on acute pancreatitis induced by cerulein in a rat experimental model. Keceli, M., Kucuk, C., Sozuer, E., Kerek, M., Ince, O., Arar, M. Journal of investigative surgery : the official journal of the Academy of Surgical Research. (2005) [Pubmed]
  9. Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells. Sohn, J.H., Bora, P.S., Suk, H.J., Molina, H., Kaplan, H.J., Bora, N.S. Nat. Med. (2003) [Pubmed]
  10. Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury. Woiciechowsky, C., Asadullah, K., Nestler, D., Eberhardt, B., Platzer, C., Schöning, B., Glöckner, F., Lanksch, W.R., Volk, H.D., Döcke, W.D. Nat. Med. (1998) [Pubmed]
  11. Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity. Stumbles, P.A., Thomas, J.A., Pimm, C.L., Lee, P.T., Venaille, T.J., Proksch, S., Holt, P.G. J. Exp. Med. (1998) [Pubmed]
  12. The effects of interleukin-10 in hemorrhagic shock. Karakozis, S., Hinds, M., Cook, J.W., Kim, D., Provido, H., Kirkpatrick, J.R. J. Surg. Res. (2000) [Pubmed]
  13. Effect of ketamine on cocaine-induced immunotoxicity in rats. Rofael, H.Z., Turkall, R.M., Abdel-Rahman, M.S. International journal of toxicology. (2003) [Pubmed]
  14. Interleukin-10 overexpression mediates phenyl-N-tert-butyl nitrone protection from endotoxemia. Kotake, Y., Sang, H., Tabatabaie, T., Wallis, G.L., Moore, D.R., Stewart, C.A. Shock (2002) [Pubmed]
  15. Effects of ketamine and propofol on the ratio of interleukin-6 to interleukin-10 during endotoxemia in rats. Taniguchi, T., Kanakura, H., Takemoto, Y., Kidani, Y., Yamamoto, K. Tohoku J. Exp. Med. (2003) [Pubmed]
  16. The inhibitory effect of interleukin-10 on mouse osteoclast formation involves novel tyrosine-phosphorylated proteins. Hong, M.H., Williams, H., Jin, C.H., Pike, J.W. J. Bone Miner. Res. (2000) [Pubmed]
  17. Kupffer cells modulate splenic interleukin-10 production in endotoxin-induced liver injury after partial hepatectomy. Kurachi, K., Suzuki, S., Sakaguchi, T., Yokoi, Y., Konno, H., Baba, S., Nakamura, S. J. Hepatol. (2003) [Pubmed]
  18. Tumor necrosis factor-alpha activates signal transduction in hypothalamus and modulates the expression of pro-inflammatory proteins and orexigenic/anorexigenic neurotransmitters. Amaral, M.E., Barbuio, R., Milanski, M., Romanatto, T., Barbosa, H.C., Nadruz, W., Bertolo, M.B., Boschero, A.C., Saad, M.J., Franchini, K.G., Velloso, L.A. J. Neurochem. (2006) [Pubmed]
  19. In vivo suppression of NF-kappa B and preservation of I kappa B alpha by interleukin-10 and interleukin-13. Lentsch, A.B., Shanley, T.P., Sarma, V., Ward, P.A. J. Clin. Invest. (1997) [Pubmed]
  20. A Regulatory CD4+ T Cell Subset in the BB Rat Model of Autoimmune Diabetes Expresses Neither CD25 Nor Foxp3. Hillebrands, J.L., Whalen, B., Visser, J.T., Koning, J., Bishop, K.D., Leif, J., Rozing, J., Mordes, J.P., Greiner, D.L., Rossini, A.A. J. Immunol. (2006) [Pubmed]
  21. Inflammatory and anti-inflammatory cytokines regulate the recovery from sublethal X irradiation in rat thymus. Mizutani, N., Fujikura, Y., Wang, Y.H., Tamechika, M., Tokuda, N., Sawada, T., Fukumoto, T. Radiat. Res. (2002) [Pubmed]
  22. Endogenous interleukin-10 is required for the defervescence of fever evoked by local lipopolysaccharide-induced and Staphylococcus aureus-induced inflammation in rats. Cartmell, T., Ball, C., Bristow, A.F., Mitchell, D., Poole, S. J. Physiol. (Lond.) (2003) [Pubmed]
  23. Thalidomide treatment in chronic constrictive neuropathy decreases endoneurial tumor necrosis factor-alpha, increases interleukin-10 and has long-term effects on spinal cord dorsal horn met-enkephalin. George, A., Marziniak, M., Schäfers, M., Toyka, K.V., Sommer, C. Pain (2000) [Pubmed]
  24. Interleukin-10 and interleukin-13 inhibit proinflammatory cytokine-induced ceramide production through the activation of phosphatidylinositol 3-kinase. Pahan, K., Khan, M., Singh, I. J. Neurochem. (2000) [Pubmed]
  25. Tacrolimus and cyclosporine differ in their capacity to overcome ongoing allograft rejection as a result of their differential abilities to inhibit interleukin-10 production. Jiang, H., Wynn, C., Pan, F., Ebbs, A., Erickson, L.M., Kobayashi, M. Transplantation (2002) [Pubmed]
  26. Interleukin-10 receptor signaling through STAT-3 regulates the apoptosis of retinal ganglion cells in response to stress. Boyd, Z.S., Kriatchko, A., Yang, J., Agarwal, N., Wax, M.B., Patil, R.V. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  27. Dysregulated luminal bacterial antigen-specific T-cell responses and antigen-presenting cell function in HLA-B27 transgenic rats with chronic colitis. Qian, B.F., Tonkonogy, S.L., Hoentjen, F., Dieleman, L.A., Sartor, R.B. Immunology (2005) [Pubmed]
  28. Attenuation of ozone-induced lung injury by interleukin-10. Reinhart, P.G., Gupta, S.K., Bhalla, D.K. Toxicol. Lett. (1999) [Pubmed]
  29. Interleukin (IL)-10 inhibits long-term IL-6 production but not preformed mediator release from rat peritoneal mast cells. Marshall, J.S., Leal-Berumen, I., Nielsen, L., Glibetic, M., Jordana, M. J. Clin. Invest. (1996) [Pubmed]
  30. Intercellular adhesion molecule-1 gene expression by glial cells. Differential mechanisms of inhibition by IL-10 and IL-6. Shrikant, P., Weber, E., Jilling, T., Benveniste, E.N. J. Immunol. (1995) [Pubmed]
  31. Phenotypic and functional characterization of vaginal dendritic cells in a rat model of Candida albicans vaginitis. De Bernardis, F., Lucciarini, R., Boccanera, M., Amantini, C., Arancia, S., Morrone, S., Mosca, M., Cassone, A., Santoni, G. Infect. Immun. (2006) [Pubmed]
  32. Interleukin-10, interleukin-4, and transforming growth factor-beta differentially regulate lipopolysaccharide-induced production of pro-inflammatory cytokines and nitric oxide in co-cultures of rat astroglial and microglial cells. Ledeboer, A., Brevé, J.J., Poole, S., Tilders, F.J., Van Dam, A.M. Glia (2000) [Pubmed]
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