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Gene Review:

TGFB2 - transforming growth factor, beta 2

Ovis aries

Kojima, K. et al., Lee, Y.C. et al.

Kojima, Ignotz, Kushibiki, Tinsley, Tabata, Vacanti,

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High impact information on TGFB2

Tissue-engineered trachea from sheep marrow stromal cells with transforming growth factor beta2 released from biodegradable microspheres in a nude rat recipient [1].
At confluence, the cells were seeded onto nonwoven polyglycolic acid fiber mesh and cultured in vitro with transforming growth factor beta 2 and insulin-like growth factor 1 for 1 week [1].
Engineering the tracheal equivalents with supplemental transforming growth factor beta 2 seemed to have a positive effect on retaining a cartilaginous phenotype in the newly forming tissue [1].
Comparing transforming growth factor-beta2, talc and bleomycin as pleurodesing agents in sheep [2].

Analytical, diagnostic and therapeutic context of TGFB2

Constructs were then coated with microspheres incorporating 0.5 microg transforming growth factor beta 2 [1].
CONCLUSIONS: Transforming growth factor-beta2 was as effective as talc and more so than bleomycin in inducing pleurodesis in sheep [2].

References

Tissue-engineered trachea from sheep marrow stromal cells with transforming growth factor beta2 released from biodegradable microspheres in a nude rat recipient. Kojima, K., Ignotz, R.A., Kushibiki, T., Tinsley, K.W., Tabata, Y., Vacanti, C.A. J. Thorac. Cardiovasc. Surg. (2004) [Pubmed]
Comparing transforming growth factor-beta2, talc and bleomycin as pleurodesing agents in sheep. Lee, Y.C., Yasay, J.R., Johnson, J.E., Parker, R.E., Thompson, P.J., Lane, K.B., Light, R.W. Respirology (2002) [Pubmed]

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