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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Rats, Nude

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Disease relevance of Rats, Nude


Psychiatry related information on Rats, Nude

  • Furthermore, nude rats bearing LC-6-JCK showed reduced locomotor activity, less eating and drinking and low blood phosphorus; and anti-PTHrP antibody restored them [6].

High impact information on Rats, Nude


Chemical compound and disease context of Rats, Nude


Biological context of Rats, Nude


Anatomical context of Rats, Nude


Associations of Rats, Nude with chemical compounds

  • Furthermore, no significant increase in substance P concentration was seen in congenitally athymic rats infected with T. spiralis [25].
  • However, when athymic rats were reconstituted with splenic mononuclear cells, increased tension to carbachol or 5-hydroxytryptamine was observed after infection [26].
  • Blood histamine concentration increased significantly in Ws/Ws and +/+ rats but did not increase in nude rats [27].
  • In nude rats carrying both a C6 and a C6tk tumor, the average ratio of tracer accumulation between the tumors was 15 +/- 5 at 2 h postinjection [28].
  • Likewise, the antitumor effects of linomide are also produced in prostatic cancer-bearing athymic nude rats [29].

Gene context of Rats, Nude

  • We found previously that expression of rat Crry on a human tumor cell line enhances tumorigenicity in nude rats [30].
  • Variant forms of rat epidermal growth factor present in the urine of nude rats bearing human tumors [31].
  • The average volume of new bone induced by 10(7) PFU of BMP vector in athymic nude rats was 0.37+/-0.03 cm(3) for ADCMVBMP-2, 0.89+/-0.07 cm(3) for ADCMVBMP-4, 1.02+/-0.07 cm(3) for ADCMVBMP-6, 0.24+/-0.05 cm(3) for ADCMVBMP-7, and 0.63+/-0.07 cm(3) for ADCMVBMP-9 [32].
  • Athymic rats given Ad-IL-1ra (n = 6) had serum levels of 493 +/- 62 pg/ml IL-1ra 14 days after transduction, and IL-1ra was detected for up to 98 days [33].
  • Moreover, immunohistological analysis of ischemic limbs from nude rats revealed that VEGF is also released from recruited human EPC in vivo [34].

Analytical, diagnostic and therapeutic context of Rats, Nude


  1. Imaging of a glioma using peripheral benzodiazepine receptor ligands. Starosta-Rubinstein, S., Ciliax, B.J., Penney, J.B., McKeever, P., Young, A.B. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  2. Intraarterial administration of melphalan for treatment of intracranial human glioma xenografts in athymic rats. Kurpad, S.N., Friedman, H.S., Archer, G.E., McLendon, R.E., Petros, W.M., Fuchs, H.E., Guaspari, A., Bigner, D.D. Cancer Res. (1995) [Pubmed]
  3. Intrathecal melphalan therapy of human neoplastic meningitis in athymic nude rats. Friedman, H.S., Archer, G.E., McLendon, R.E., Schuster, J.M., Colvin, O.M., Guaspari, A., Blum, R., Savina, P.A., Fuchs, H.E., Bigner, D.D. Cancer Res. (1994) [Pubmed]
  4. Site-dependent differences in sensitivity of LOX human melanoma tumors in nude rats to dacarbazine and mitozolomide, but not to doxorubicin and cisplatin. Kjønniksen, I., Breistøl, K., Fodstad, O. Cancer Res. (1992) [Pubmed]
  5. Melatonin-depleted blood from premenopausal women exposed to light at night stimulates growth of human breast cancer xenografts in nude rats. Blask, D.E., Brainard, G.C., Dauchy, R.T., Hanifin, J.P., Davidson, L.K., Krause, J.A., Sauer, L.A., Rivera-Bermudez, M.A., Dubocovich, M.L., Jasser, S.A., Lynch, D.T., Rollag, M.D., Zalatan, F. Cancer Res. (2005) [Pubmed]
  6. Parathyroid hormone-related protein (PTHrP) as a causative factor of cancer-associated wasting: possible involvement of PTHrP in the repression of locomotor activity in rats bearing human tumor xenografts. Onuma, E., Tsunenari, T., Saito, H., Sato, K., Yamada-Okabe, H., Ogata, E. Int. J. Cancer (2005) [Pubmed]
  7. Growth arrest of solid human neuroblastoma xenografts in nude rats by natural IgM from healthy humans. David, K., Ollert, M.W., Juhl, H., Vollmert, C., Erttmann, R., Vogel, C.W., Bredehorst, R. Nat. Med. (1996) [Pubmed]
  8. Inhibition of neointimal smooth muscle accumulation after angioplasty by an antibody to PDGF. Ferns, G.A., Raines, E.W., Sprugel, K.H., Motani, A.S., Reidy, M.A., Ross, R. Science (1991) [Pubmed]
  9. Transin/stromelysin expression in the synovium of rats with experimental erosive arthritis. In situ localization and kinetics of expression of the transformation-associated metalloproteinase in euthymic and athymic Lewis rats. Case, J.P., Sano, H., Lafyatis, R., Remmers, E.F., Kumkumian, G.K., Wilder, R.L. J. Clin. Invest. (1989) [Pubmed]
  10. The mechanism of altered neural function in a rat model of acute colitis. Jacobson, K., McHugh, K., Collins, S.M. Gastroenterology (1997) [Pubmed]
  11. Effect of endogenous hypergastrinemia on gastrin receptor expressing human colon carcinoma transplanted to athymic rats. Chu, M., Nielsen, F.C., Franzén, L., Rehfeld, J.F., Holst, J.J., Borch, K. Gastroenterology (1995) [Pubmed]
  12. Antitumor activity of P-4055 (elaidic acid-cytarabine) compared to cytarabine in metastatic and s.c. human tumor xenograft models. Breistøl, K., Balzarini, J., Sandvold, M.L., Myhren, F., Martinsen, M., De Clercq, E., Fodstad, O. Cancer Res. (1999) [Pubmed]
  13. Cyclooxygenase-2 is expressed in neuroblastoma, and nonsteroidal anti-inflammatory drugs induce apoptosis and inhibit tumor growth in vivo. Johnsen, J.I., Lindskog, M., Ponthan, F., Pettersen, I., Elfman, L., Orrego, A., Sveinbjörnsson, B., Kogner, P. Cancer Res. (2004) [Pubmed]
  14. Intravenous adenosine selectively increases blood flow to xenotransplanted intracerebral gliomas. Warnke, P.C., Molnar, P., Bigner, D.D., Heistad, D.H., Groothuis, D.R. Neurology (1987) [Pubmed]
  15. Acute and chronic polyarthritis induced by an aqueous form of 6-O-acyl and N-acyl derivatives of N-acetylmuramyl-L-alanyl-D-isoglutamine in euthymic rats and athymic nude rats. Kohashi, O., Kohashi, Y., Shigematsu, N., Ozawa, A., Kotani, S. Lab. Invest. (1986) [Pubmed]
  16. TNF-alpha gene and proton radiotherapy in an orthotopic brain tumor model. Gridley, D.S., Baer, J.R., Cao, J.D., Miller, G.M., Kim, D.W., Timiryasova, T.M., Fodor, I., Slater, J.M. Int. J. Oncol. (2002) [Pubmed]
  17. Transplantation tolerance and autoimmunity after xenogeneic thymus transplantation. Xia, G., Goebels, J., Rutgeerts, O., Vandeputte, M., Waer, M. J. Immunol. (2001) [Pubmed]
  18. In vivo endochondral bone formation using a bone morphogenetic protein 2 adenoviral vector. Alden, T.D., Pittman, D.D., Hankins, G.R., Beres, E.J., Engh, J.A., Das, S., Hudson, S.B., Kerns, K.M., Kallmes, D.F., Helm, G.A. Hum. Gene Ther. (1999) [Pubmed]
  19. Morphologic analysis of BMP-9 gene therapy-induced osteogenesis. Varady, P., Li, J.Z., Cunningham, M., Beres, E.J., Das, S., Engh, J., Alden, T.D., Pittman, D.D., Kerns, K.M., Kallmes, D.F., Helm, G.A. Hum. Gene Ther. (2001) [Pubmed]
  20. 68Ga-labeled oligonucleotides for in vivo imaging with PET. Roivainen, A., Tolvanen, T., Salomäki, S., Lendvai, G., Velikyan, I., Numminen, P., Välilä, M., Sipilä, H., Bergström, M., Härkönen, P., Lönnberg, H., Långström, B. J. Nucl. Med. (2004) [Pubmed]
  21. Molecular biologic characteristics of seven new cell lines of squamous cell carcinomas of the head and neck and comparison to fresh tumor tissue. Welkoborsky, H.J., Jacob, R., Riazimand, S.H., Bernauer, H.S., Mann, W.J. Oncology (2003) [Pubmed]
  22. Normal human serum contains a natural IgM antibody cytotoxic for human neuroblastoma cells. Ollert, M.W., David, K., Schmitt, C., Hauenschild, A., Bredehorst, R., Erttmann, R., Vogel, C.W. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  23. Natural killer cell- and macrophage-mediated rejection of concordant xenografts in the absence of T and B cell responses. Lin, Y., Vandeputte, M., Waer, M. J. Immunol. (1997) [Pubmed]
  24. In vivo assessment of isolated pancreatic islet viability using the streptozotocin-induced diabetic nude rat. Lake, S.P., Chamberlain, J., Husken, P., Bell, P.R., James, R.F. Diabetologia (1988) [Pubmed]
  25. Increased levels of substance P in the myenteric plexus of Trichinella-infected rats. Swain, M.G., Agro, A., Blennerhassett, P., Stanisz, A., Collins, S.M. Gastroenterology (1992) [Pubmed]
  26. T-lymphocyte modulation of intestinal muscle function in the Trichinella-infected rat. Vermillion, D.L., Ernst, P.B., Collins, S.M. Gastroenterology (1991) [Pubmed]
  27. Infection of Nippostrongylus brasiliensis induces normal increase of basophils in mast cell-deficient Ws/Ws rats with a small deletion at the kinase domain of c-kit. Kasugai, T., Okada, M., Morimoto, M., Arizono, N., Maeyama, K., Yamada, M., Tei, H., Dohmae, K., Onoue, H., Newlands, G.F. Blood (1993) [Pubmed]
  28. Monitoring of herpes simplex virus thymidine kinase enzyme activity using positron emission tomography. Hospers, G.A., Calogero, A., van Waarde, A., Doze, P., Vaalburg, W., Mulder, N.H., de Vries, E.F. Cancer Res. (2000) [Pubmed]
  29. The antitumor effects of the quinoline-3-carboxamide linomide on Dunning R-3327 rat prostatic cancers. Ichikawa, T., Lamb, J.C., Christensson, P.I., Hartley-Asp, B., Isaacs, J.T. Cancer Res. (1992) [Pubmed]
  30. Expression of rat complement control protein Crry on tumor cells inhibits rat natural killer cell-mediated cytotoxicity. Caragine, T.A., Imai, M., Frey, A.B., Tomlinson, S. Blood (2002) [Pubmed]
  31. Variant forms of rat epidermal growth factor present in the urine of nude rats bearing human tumors. Hudgins, W.R., Orth, D.N., Stromberg, K. Cancer Res. (1988) [Pubmed]
  32. Osteogenic potential of five different recombinant human bone morphogenetic protein adenoviral vectors in the rat. Li, J.Z., Li, H., Sasaki, T., Holman, D., Beres, B., Dumont, R.J., Pittman, D.D., Hankins, G.R., Helm, G.A. Gene Ther. (2003) [Pubmed]
  33. Systemic delivery of the interleukin-1 receptor antagonist protein using a new strategy of direct adenoviral-mediated gene transfer to skeletal muscle capillary endothelium in the isolated rat hindlimb. Welling, T.H., Davidson, B.L., Zelenock, J.A., Stanley, J.C., Gordon, D., Roessler, B.J., Messina, L.M. Hum. Gene Ther. (1996) [Pubmed]
  34. Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells. Urbich, C., Aicher, A., Heeschen, C., Dernbach, E., Hofmann, W.K., Zeiher, A.M., Dimmeler, S. J. Mol. Cell. Cardiol. (2005) [Pubmed]
  35. Regional delivery and selective expression of a high-activity yeast cytosine deaminase in an intrahepatic colon cancer model. Zhang, M., Li, S., Nyati, M.K., DeRemer, S., Parsels, J., Rehemtulla, A., Ensminger, W.D., Lawrence, T.S. Cancer Res. (2003) [Pubmed]
  36. High-dosed nicotinamide decreases early graft failure after pig to nude rat intraportal islet transplantation. Brandhorst, D., Brandhorst, H., Zwolinski, A., Nahidi, F., Bretzel, R.G. Transplantation (2002) [Pubmed]
  37. The proliferation and life-span of rat large granular lymphocytes: effects of cytokines. Vaage, J.T., Reynolds, C.W., Reynolds, D., Fossum, S., Rolstad, B. Eur. J. Immunol. (1989) [Pubmed]
  38. Influence of IN-1 antibody and acidic FGF-fibrin glue on the response of injured corticospinal tract axons to human Schwann cell grafts. Guest, J.D., Hesse, D., Schnell, L., Schwab, M.E., Bunge, M.B., Bunge, R.P. J. Neurosci. Res. (1997) [Pubmed]
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