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MeSH Review


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Disease relevance of Pleurodesis


High impact information on Pleurodesis


Chemical compound and disease context of Pleurodesis


Biological context of Pleurodesis


Anatomical context of Pleurodesis


Associations of Pleurodesis with chemical compounds

  • MAIN RESULTS: The 20 patients with low-pH malignant effusions had a significantly greater positivity on initial pleural fluid cytologic evaluation, a shorter mean survival, and a poorer response to tetracycline pleurodesis compared with 40 patients with normal-pH malignant effusions [1].
  • Since 1983 intrathoracic instillation of the anti-malaria drug mepacrine has been used to achieve pleurodesis [11].
  • Immunosuppressive treatment, diet, and underwater seal drainage led to a diminished volume of pleural fluid and pericardial fluid and to a diminished concentration of triglyceride in them; pleurodesis with tetracycline was then performed [24].
  • Chemical pleurodesis with mitoxantrone in the management of malignant effusions [25].
  • They can be divided into 2 major groups: systemic therapy (immunosuppressive therapy, plasmapheresis, and intravenous immunoglobulin) and local therapy (intrapleural steroid injections, pleurodesis with talc or tetracycline, and pleurectomy) [26].

Gene context of Pleurodesis

  • Furthermore, MMP-9 levels were variable; in fact, in some patients they were high at the beginning of treatment, in others they increased a few days after pleurodesis induction [27].
  • The levels of u-PA in patients who did not respond to chemical pleurodesis were significantly higher than those who had complete response (p=0.0001) [28].
  • RESULTS: At day 14, the pleurodesis score of the TGF-beta2 group (7.7+/-0.6) was similar to that of the talc (7.0+/-1.7) group and significantly higher than that of the bleomycin group (3.3+/-2.3; P < 0.05) [29].
  • The aims of the present study were to compare: (i) the effectiveness of TGF-beta2, talc and bleomycin in producing pleurodesis in sheep; (ii) the acute side-effects and systemic TGF-beta levels following the intrapleural administration of these agents; and (iii) histological changes after intrapleural injections of these agents [29].
  • Intrapleural instillation of TNF appears to be an effective method for achieving pleurodesis with relatively few side-effects and can be successful even after other methods have failed [30].

Analytical, diagnostic and therapeutic context of Pleurodesis


  1. Pleural fluid pH in malignant effusions. Diagnostic, prognostic, and therapeutic implications. Sahn, S.A., Good, J.T. Ann. Intern. Med. (1988) [Pubmed]
  2. Spontaneous pneumothorax: comparison of simple drainage, talc pleurodesis, and tetracycline pleurodesis. Almind, M., Lange, P., Viskum, K. Thorax (1989) [Pubmed]
  3. Pleurodesis for refractory pleural effusion in systemic lupus erythematosus. Putterman, C., Kramer, M., Ben-Chetrit, E. J. Rheumatol. (1993) [Pubmed]
  4. Acute respiratory failure after pleurodesis with doxycycline. DiBardino, D.J., Vanatta, J.M., Fagan, S.P., Awad, S.S. Ann. Thorac. Surg. (2002) [Pubmed]
  5. Effects of additional minocycline pleurodesis after thoracoscopic procedures for primary spontaneous pneumothorax. Chen, J.S., Hsu, H.H., Kuo, S.W., Tsai, P.R., Chen, R.J., Lee, J.M., Lee, Y.C. Chest (2004) [Pubmed]
  6. Elastance of the pleural space: a predictor for the outcome of pleurodesis in patients with malignant pleural effusion. Lan, R.S., Lo, S.K., Chuang, M.L., Yang, C.T., Tsao, T.C., Lee, C.H. Ann. Intern. Med. (1997) [Pubmed]
  7. Prospective randomized trial of intrapleural bleomycin versus interferon alfa-2b via ultrasound-guided small-bore chest tube in the palliative treatment of malignant pleural effusions. Sartori, S., Tassinari, D., Ceccotti, P., Tombesi, P., Nielsen, I., Trevisani, L., Abbasciano, V. J. Clin. Oncol. (2004) [Pubmed]
  8. Additional minocycline pleurodesis after thoracoscopic surgery for primary spontaneous pneumothorax. Chen, J.S., Hsu, H.H., Chen, R.J., Kuo, S.W., Huang, P.M., Tsai, P.R., Lee, J.M., Lee, Y.C. Am. J. Respir. Crit. Care Med. (2006) [Pubmed]
  9. Failure of talc pleurodesis is associated with increased pleural fibrinolysis. Rodriguez-Panadero, F., Segado, A., Martin Juan, J., Ayerbe, R., Torres Garcia, I., Castillo, J. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  10. Transforming growth factor beta2 induced pleurodesis is not inhibited by corticosteroids. Lee, Y.C., Devin, C.J., Teixeira, L.R., Rogers, J.T., Thompson, P.J., Lane, K.B., Light, R.W. Thorax (2001) [Pubmed]
  11. Chemical pleurodesis in malignant pleural effusions: a randomised prospective study of mepacrine versus bleomycin. Koldsland, S., Svennevig, J.L., Lehne, G., Johnson, E. Thorax (1993) [Pubmed]
  12. Prospective randomized trial of silver nitrate vs talc slurry in pleurodesis for symptomatic malignant pleural effusions. Paschoalini, M.d.a. .S., Vargas, F.S., Marchi, E., Pereira, J.R., Jatene, F.B., Antonangelo, L., Light, R.W. Chest (2005) [Pubmed]
  13. Pulmonary lymphangiomyomatosis associated with tuberous sclerosis. Treatment with tamoxifen and tetracycline-pleurodesis. Luna, C.M., Gené, R., Jolly, E.C., Nahmod, N., Defranchi, H.A., Patiño, G., Elsner, B. Chest (1985) [Pubmed]
  14. Multilevel and continuous pleural fluid pH likelihood ratios for evaluating malignant pleural effusions. Heffner, J.E., Heffner, J.N., Brown, L.K. Chest (2003) [Pubmed]
  15. Zinc chloride smoke inhalation: a rare cause of severe acute respiratory distress syndrome. Pettilä, V., Takkunen, O., Tukiainen, P. Intensive care medicine. (2000) [Pubmed]
  16. Chylothorax after childbirth. Cammarata, S.K., Brush, R.E., Hyzy, R.C. Chest (1991) [Pubmed]
  17. Talc-induced inflammation in the pleural cavity. van den Heuvel, M.M., Smit, H.J., Barbierato, S.B., Havenith, C.E., Beelen, R.H., Postmus, P.E. Eur. Respir. J. (1998) [Pubmed]
  18. Pharmacokinetics of quinacrine after intrapleural instillation in rabbits and man. Björkman, S., Elisson, L.O., Gabrielsson, J. J. Pharm. Pharmacol. (1989) [Pubmed]
  19. A case of intrathoracic extramedullary hematopoiesis with massive pleural effusion: successful pleurodesis with intrapleural minocycline. Peng, M.J., Kuo, H.T., Chang, M.C. J. Formos. Med. Assoc. (1994) [Pubmed]
  20. Tetracycline pleurodesis during active pulmonary-pleural air leak for prevention of recurrent pneumothorax. Macoviak, J.A., Stephenson, L.W., Ochs, R., Edmunds, L.H. Chest (1982) [Pubmed]
  21. The effect of experimental pleurodesis caused by aluminum hydroxide on lung and chest wall mechanics. Albuquerque, D.A., Seidl, V.R., Santos, V.C., Oliveira-Neto, J.A., Capelozzi, V.L., Rocco, P.R., Zin, W.A. Lung (2001) [Pubmed]
  22. Pleurodesis induced by talc or silver nitrate: evaluation of collagen and elastic fibers in pleural remodeling. Antonangelo, L., Vargas, F.S., Teixeira, L.R., Acencio, M.M., Vaz, M.A., Filho, M.T., Marchi, E. Lung (2006) [Pubmed]
  23. Mechanism of tetracycline-hydrochloride-induced pleurodesis. Tetracycline-hydrochloride-stimulated mesothelial cells produce a growth-factor-like activity for fibroblasts. Antony, V.B., Rothfuss, K.J., Godbey, S.W., Sparks, J.A., Hott, J.W. Am. Rev. Respir. Dis. (1992) [Pubmed]
  24. Life threatening chylous pleural and pericardial effusion in a patient with Behçet's syndrome. Cöplü, L., Emrí, S., Selçuk, Z.T., Kalyoncu, F., Balkanci, F., Sahín, A.A., Bariş, Y.I. Thorax (1992) [Pubmed]
  25. Chemical pleurodesis with mitoxantrone in the management of malignant effusions. van Belle, A.F., ten Velde, G.P., Wouters, E.F. Eur. J. Cancer (1998) [Pubmed]
  26. Therapeutic options for refractory massive pleural effusion in systemic lupus erythematosus: a case study and review of the literature. Breuer, G.S., Deeb, M., Fisher, D., Nesher, G. Semin. Arthritis Rheum. (2005) [Pubmed]
  27. Matrix metalloproteinases production in malignant pleural effusions after talc pleurodesis. D'Agostino, P., Camemi, A.R., Caruso, R., Arcoleo, F., Cascio, A., Dolce, A., Sacco, E., Cangemi, G., di Rosa, T., Moceo, P., Cillari, E. Clin. Exp. Immunol. (2003) [Pubmed]
  28. Urokinase-type plasminogen activator in carcinomatous pleural fluid. Ishikawa, H., Satoh, H., Hasegawa, S., Yazawa, T., Naito, T., Yamashita, Y.T., Ohtsuka, M., Ogata, T., Kamma, H. Eur. Respir. J. (1997) [Pubmed]
  29. Comparing transforming growth factor-beta2, talc and bleomycin as pleurodesing agents in sheep. Lee, Y.C., Yasay, J.R., Johnson, J.E., Parker, R.E., Thompson, P.J., Lane, K.B., Light, R.W. Respirology (2002) [Pubmed]
  30. Recombinant tumour necrosis factor in the local therapy of malignant pleural effusion. Rauthe, G., Sistermanns, J. Eur. J. Cancer (1997) [Pubmed]
  31. Prospective randomized comparison of thoracoscopic talc poudrage under local anesthesia versus bleomycin instillation for pleurodesis in malignant pleural effusions. Diacon, A.H., Wyser, C., Bolliger, C.T., Tamm, M., Pless, M., Perruchoud, A.P., Solèr, M. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  32. Diagnosis and management of malignant pleural effusions. Fenton, K.N., Richardson, J.D. Am. J. Surg. (1995) [Pubmed]
  33. Secondary spontaneous pneumothorax. Tanaka, F., Itoh, M., Esaki, H., Isobe, J., Ueno, Y., Inoue, R. Ann. Thorac. Surg. (1993) [Pubmed]
  34. Doxycycline pleurodesis in rabbits: comparison of results with and without chest tube. Wu, W., Teixeira, L.R., Light, R.W. Chest (1998) [Pubmed]
  35. Effect of diclofenac on experimental pleurodesis induced by tetracycline in rabbits. Ors Kaya, S., Bir, F., Atalay, H., Onem, G., Aytekin, F.O., Saçar, M. J. Investig. Med. (2005) [Pubmed]
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