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Chemical Compound Review

Polyglycolide     2-hydroxyethanoic acid

Synonyms: GlyPure, Glycocide, glycolate, GLYCOLLATE, hydroxyacetate, ...
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Disease relevance of POLYGLYCOLIC ACID


Psychiatry related information on POLYGLYCOLIC ACID


High impact information on POLYGLYCOLIC ACID

  • Primary hyperoxaluria type 1 (PH 1), an inborn error of glyoxylate metabolism characterized by excessive synthesis of oxalate and glycolate, is caused by a defect in serine:pyruvate/alanine:glyoxylate aminotransferase (SPT/AGT) [8].
  • Beginning at about day 3, light-induced activities of enzymes involved in photorespiratory glycolate metabolism accumulate rapidly in microbodies [9].
  • To neutralize the acids liberated by the biodegradable lactic/glycolic acid-based polyester, we coincorporated into the polymer an antacid, Mg(OH)2, which increased microclimate pH and prevented BSA structural losses and aggregation for over one month [10].
  • In a strategy to circumvent the complicated purification protocols for MIS, Chinese hamster ovary cells transfected with the human MIS gene were seeded onto biodegradable polymers of polyglycolic acid fibers and secretion of MIS confirmed [11].
  • In all animals, the TEL persisted in the pulmonary valve position after 8 to 10 weeks, and all polyglycolic acid polymer had been degraded [12].

Chemical compound and disease context of POLYGLYCOLIC ACID


Biological context of POLYGLYCOLIC ACID

  • The polypeptide chain folding near the FAD binding site is different from those observed in other flavoproteins, such as glutathione reductase and glycolate oxidase [18].
  • Association of glycolate oxidation with photosynthetic electron transport in plant and algal chloroplasts [19].
  • This operon, activated by growth on glycolate, is transcribed as a single message and is under the positive control of GlcC encoded by a divergent gene [20].
  • The key steps include a Sharpless kinetic resolution and an asymmetric glycolate alkylation to establish the stereogenic centers adjacent to the ether linkage and a ring-closing metathesis reaction to construct the nine-membered ether without the aid of a cyclic conformational constraint [21].
  • The use of polyglycolic acid (PGA) stretchable mesh applied to the experimentally injured canine spleen can achieve satisfactory immediate hemostasis by tamponade and simplifies the use of sutures to control remaining areas of hemorrhage [22].

Anatomical context of POLYGLYCOLIC ACID


Associations of POLYGLYCOLIC ACID with other chemical compounds




Analytical, diagnostic and therapeutic context of POLYGLYCOLIC ACID


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  14. The plant-like c2 glycolate cycle and the bacterial-like glycerate pathway cooperate in phosphoglycolate metabolism in cyanobacteria. Eisenhut, M., Kahlon, S., Hasse, D., Ewald, R., Lieman-Hurwitz, J., Ogawa, T., Ruth, W., Bauwe, H., Kaplan, A., Hagemann, M. Plant Physiol. (2006) [Pubmed]
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  17. The cbb operons of the facultative chemoautotroph Alcaligenes eutrophus encode phosphoglycolate phosphatase. Schäferjohann, J., Yoo, J.G., Kusian, B., Bowien, B. J. Bacteriol. (1993) [Pubmed]
  18. Structure of the medium-chain acyl-CoA dehydrogenase from pig liver mitochondria at 3-A resolution. Kim, J.J., Wu, J. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
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  21. Enantioselective total synthesis of (+)-obtusenyne. Crimmins, M.T., Powell, M.T. J. Am. Chem. Soc. (2003) [Pubmed]
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  23. Tissue-engineered heart valves. Autologous valve leaflet replacement study in a lamb model. Shinoka, T., Ma, P.X., Shum-Tim, D., Breuer, C.K., Cusick, R.A., Zund, G., Langer, R., Vacanti, J.P., Mayer, J.E. Circulation (1996) [Pubmed]
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  26. Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases. Jones, J.M., Morrell, J.C., Gould, S.J. J. Biol. Chem. (2000) [Pubmed]
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  28. Structural and spectroscopic studies shed light on the mechanism of oxalate oxidase. Opaleye, O., Rose, R.S., Whittaker, M.M., Woo, E.J., Whittaker, J.W., Pickersgill, R.W. J. Biol. Chem. (2006) [Pubmed]
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  34. The gene yghK linked to the glc operon of Escherichia coli encodes a permease for glycolate that is structurally and functionally similar to L-lactate permease. Núñez, M.F., Pellicer, M.T., Badía, J., Aguilar, J., Baldomà, L. Microbiology (Reading, Engl.) (2001) [Pubmed]
  35. Microspheres of biodegradable polymers as a drug-delivery system in the vitreous. Moritera, T., Ogura, Y., Honda, Y., Wada, R., Hyon, S.H., Ikada, Y. Invest. Ophthalmol. Vis. Sci. (1991) [Pubmed]
  36. Surgical relief of causalgia with an artificial nerve guide tube: Successful surgical treatment of causalgia (Complex Regional Pain Syndrome Type II) by in situ tissue engineering with a polyglycolic acid-collagen tube. Inada, Y., Morimoto, S., Moroi, K., Endo, K., Nakamura, T. Pain (2005) [Pubmed]
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