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Gene Review

VPS35  -  vacuolar protein sorting 35 homolog (S....

Homo sapiens

Synonyms: FLJ10752, MEM3, Maternal-embryonic 3, PARK17, TCCCTA00141, ...
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High impact information on VPS35

  • Cell culture studies, using small interfering RNAs or expression vectors, showed that VPS35 regulates Abeta peptide levels, establishing the relevance of the retromer complex to AD [1].
  • VPS35 is the core molecule of the retromer trafficking complex and further analysis revealed that VPS26, another member of the complex, is also downregulated in AD [1].
  • Cloning and characterization of human VPS35 and mouse Vps35 and mapping of VPS35 to human chromosome 16q13-q21 [2].
  • The studies on yeast (Saccharomyces cerevisiae) VPS35, a hydrophilic membrane protein having a direct role in the retrieval of cargo proteins, suggest a mechanism underlying a possible lysosomal protein-sorting pathway in mammalian cells [2].
  • The results of Northern hybridization of human VPS35 in 16 tissues showed that one transcript of 3.6 kb was highly expressed in brain, heart, testis, ovary, small intestine, spleen, skeletal muscle, and placenta and expressed at moderate or low levels in other tissues [2].

Biological context of VPS35


Analytical, diagnostic and therapeutic context of VPS35

  • Western blotting confirmed the abnormality, establishing that VPS35 levels are reduced in brain regions selectively vulnerable to AD [1].


  1. Model-guided microarray implicates the retromer complex in Alzheimer's disease. Small, S.A., Kent, K., Pierce, A., Leung, C., Kang, M.S., Okada, H., Honig, L., Vonsattel, J.P., Kim, T.W. Ann. Neurol. (2005) [Pubmed]
  2. Cloning and characterization of human VPS35 and mouse Vps35 and mapping of VPS35 to human chromosome 16q13-q21. Zhang, P., Yu, L., Gao, J., Fu, Q., Dai, F., Zhao, Y., Zheng, L., Zhao, S. Genomics (2000) [Pubmed]
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