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Gene Review

Pdss1  -  prenyl (solanesyl) diphosphate synthase,...

Mus musculus

Synonyms: 2610203G20Rik, 2700031G06Rik, All-trans-decaprenyl-diphosphate synthase subunit 1, Decaprenyl pyrophosphate synthase subunit 1, Decaprenyl-diphosphate synthase subunit 1, ...
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Disease relevance of Pdss1

  • In particular 7-cyano-20S-camptothecin (5a) showed high in vitro cytotoxicity against a topotecan-resistant H460 cell subline (H460/TPT) and a cisplatin-resistant ovarian carcinoma subline (IGROV-1/Pt 1) [1].
  • In mammalian muscles, the contraction time (TPT), relaxation time (RT1/2), and maximum tetanus tension (Po) of bundles of fiber segments were not different from those of intact fibers, but the rate of tension development (dP/dt), twitch-to-tetanus ratio (Pt/Po) and Vo were lower [2].

High impact information on Pdss1


Analytical, diagnostic and therapeutic context of Pdss1

  • H4 S1ph may promote chromatin compaction, since deletion of SPS1 increases accessibility to antibody immunoprecipitation; furthermore, either deletion of Sps1 or an H4 S1A substitution results in increased DNA volume in nuclei within spores [4].
  • Here we describe a method, which we call TPTP (two-photon targeted patching), that uses two-photon imaging to guide in vivo whole-cell recordings to individual, genetically labeled cortical neurons [5].
  • Differential sensitivity between murine and human myeloid progenitors explains why the curative doses of TPT and 9AC in mice with human tumor xenografts are not achievable in patients [6].


  1. Novel 7-substituted camptothecins with potent antitumor activity. Dallavalle, S., Delsoldato, T., Ferrari, A., Merlini, L., Penco, S., Carenini, N., Perego, P., De Cesare, M., Pratesi, G., Zunino, F. J. Med. Chem. (2000) [Pubmed]
  2. Contractile properties of bundles of fiber segments from skeletal muscles. Faulkner, J.A., Claflin, D.R., McCully, K.K., Jones, D.A. Am. J. Physiol. (1982) [Pubmed]
  3. Influence of peroxisome proliferator-activated receptor alpha on ubiquinone biosynthesis. Turunen, M., Peters, J.M., Gonzalez, F.J., Schedin, S., Dallner, G. J. Mol. Biol. (2000) [Pubmed]
  4. Phosphorylation of histone H4 Ser1 regulates sporulation in yeast and is conserved in fly and mouse spermatogenesis. Krishnamoorthy, T., Chen, X., Govin, J., Cheung, W.L., Dorsey, J., Schindler, K., Winter, E., Allis, C.D., Guacci, V., Khochbin, S., Fuller, M.T., Berger, S.L. Genes Dev. (2006) [Pubmed]
  5. Targeted whole-cell recordings in the mammalian brain in vivo. Margrie, T.W., Meyer, A.H., Caputi, A., Monyer, H., Hasan, M.T., Schaefer, A.T., Denk, W., Brecht, M. Neuron (2003) [Pubmed]
  6. Differential toxicity of camptothecin, topotecan and 9-aminocamptothecin to human, canine, and murine myeloid progenitors (CFU-GM) in vitro. Erickson-Miller, C.L., May, R.D., Tomaszewski, J., Osborn, B., Murphy, M.J., Page, J.G., Parchment, R.E. Cancer Chemother. Pharmacol. (1997) [Pubmed]
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