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Gene Review

PDSS1  -  prenyl (decaprenyl) diphosphate synthase,...

Homo sapiens

Synonyms: All-trans-decaprenyl-diphosphate synthase subunit 1, COQ1, COQ10D2, DPS, DPS1, ...
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Disease relevance of PDSS1

  • As agents with a novel mechanism of action, tolerable toxicity, and encouraging antitumor activity in early clinical trials, TPT and CPT-11 are undergoing further clinical development [1].
  • We observed that in SJ-G5 human anaplastic astrocytoma cells growing in culture, the maximum number of topoisomerase I-DNA complexes occurred 5-15 min after the addition of 0.25-25 microM 9-dimethylaminomethyl-10-hydroxycamptothecin (topotecan; TPT) or 5 microM 7-ethyl-10-hydroxycamptothecin (SN-38) [2].
  • Our results showed PDSS to have significant immunophenotypic overlap with both PNETs and MPNSTs [3].
  • Monomorphic spindled variants, as well as the less common poorly differentiated variants, may be confused with other soft-tissue sarcomas; the poorly differentiated variant (PDSS), in particular, may be histologically indistinguishable from other small, blue, round cell tumors, including primitive neuroectodermal tumors (PNETs) [3].
  • BACKGROUND: Small cell variant ofpoorly differentiated synovial sarcoma (PDSS) is a great mimic of Ewing's sarcoma/primitive neuroectodermal tumor, with cytologic and immunohistochemical overlap [4].

Psychiatry related information on PDSS1

  • When compared to the original English version of the PDSS, the psychometrics for the Spanish version were slightly lower but well within the acceptable range [5].

High impact information on PDSS1

  • In addition, decreased metabolic activation of CPT-11 (which is a pro-drug) and active efflux of TPT by P-glycoprotein-mediated transport might contribute to resistance [1].
  • It has been identified as the triose phosphate translocator (TPT) exporting the primary products of the Calvin cycle (i.e., triose phosphates and 3-phosphoglycerate) out of the chloroplast in a strict counter exchange for Pi [6].
  • The reduced TPT activity leads to a reduction of maximal photosynthesis by 40-60%, to a change in carbon partitioning into starch at the expense of sucrose and amino acids, and to an increase of the leaf starch content by a factor of approximately 3 [6].
  • Topotecan efflux was inhibited and accumulation was partially restored in CL1/Tpt and MCF7/TPT cells when cells were incubated simultaneously with gefitinib [7].
  • In contrast, these concentrations of gefitinib caused a dose-dependent reversal of resistance to paclitaxel in CL1/Pac cells, to doxorubicin in MCF7/ADR cells, and to topotecan in CL1/Tpt and MCF7/TPT cells [7].

Chemical compound and disease context of PDSS1

  • The high toxicity of this schedule and the recent understanding of the pharmacokinetic interaction between those drugs may encourage the investigation of the alternate sequence of cisplatin after TPT in phase II studies [8].

Biological context of PDSS1

  • Addition of quinidine enhanced TPT accumulation (measured by high-performance liquid chromatography) and diminished the IC50 for TPT to a greater extent in CHRC5 cells than in AuxB1 cells [9].
  • For example, does TPT occur at a given gestational age, in the context of a particular type of pathology or when a drug is administered by a certain dosage regimen [10]?
  • The backbone conformation of the TPTP phosphate binding loop is nearly superimposable with that of other tyrosine phosphatases, with N14 existing in a strained, left-handed conformation that is a hallmark of the active site hydrogen bonding network in the LMW PTPs [11].
  • The use of TPT in agriculture or as an antifouling agent, its transport to the deep-sea environment associated to particulate matter, and its nonbiodegradable nature in the food chain may account for the high residue levels detected in deep-sea organisms [12].
  • Enzyme phosphorylation by ATP and dephosphorylation took place in the TPT system [13].

Anatomical context of PDSS1


Associations of PDSS1 with chemical compounds


Other interactions of PDSS1


Analytical, diagnostic and therapeutic context of PDSS1

  • Results showed that topoisomerase I dissociated from nucleoli within 60 min after treatment with 1-5 microM TPT [2].
  • Band depletion immunoblotting revealed that 4-fold higher concentrations of extracellular TPT were required to induce the formation of topo I-DNA complexes in CHRC5 cells as compared to AuxB1 cells [9].
  • To investigate these possibilities, we incubated SJ-G5 cells for 20-60 min with 0.25-5 microM TPT and analyzed the cells for amount and localization of topoisomerase I by indirect immunofluorescence staining and fluorescence digital imaging microscopy [2].
  • The control group had a mean TPT of 34.4 +/- 16.1 seconds (range 0 to 130 seconds) (P <.001) and a mean EPT of 20.0 +/- 12.8 seconds (range 0 to 107 seconds) (P <.001) [19].
  • After neurological examinations, we assessed the degree of sleep disorder by the PDSS [20].


  1. The current status of camptothecin analogues as antitumor agents. Slichenmyer, W.J., Rowinsky, E.K., Donehower, R.C., Kaufmann, S.H. J. Natl. Cancer Inst. (1993) [Pubmed]
  2. Subcellular redistribution of DNA topoisomerase I in anaplastic astrocytoma cells treated with topotecan. Danks, M.K., Garrett, K.E., Marion, R.C., Whipple, D.O. Cancer Res. (1996) [Pubmed]
  3. Poorly differentiated synovial sarcoma: immunohistochemical distinction from primitive neuroectodermal tumors and high-grade malignant peripheral nerve sheath tumors. Folpe, A.L., Schmidt, R.A., Chapman, D., Gown, A.M. Am. J. Surg. Pathol. (1998) [Pubmed]
  4. Aspiration cytology of pulmonary small cell variant of poorly differentiated synovial sarcoma metastatic from the tongue: a case report. Kwon, M.S. Acta Cytol. (2005) [Pubmed]
  5. Screening performance of the postpartum depression screening scale--Spanish version. Beck, C.T., Gable, R.K. Journal of transcultural nursing : official journal of the Transcultural Nursing Society / Transcultural Nursing Society. (2005) [Pubmed]
  6. Antisense repression of the chloroplast triose phosphate translocator affects carbon partitioning in transgenic potato plants. Riesmeier, J.W., Flügge, U.I., Schulz, B., Heineke, D., Heldt, H.W., Willmitzer, L., Frommer, W.B. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  7. Gefitinib reverses chemotherapy resistance in gefitinib-insensitive multidrug resistant cancer cells expressing ATP-binding cassette family protein. Yang, C.H., Huang, C.J., Yang, C.S., Chu, Y.C., Cheng, A.L., Whang-Peng, J., Yang, P.C. Cancer Res. (2005) [Pubmed]
  8. Phase I study of daily times five topotecan and single injection of cisplatin in patients with previously untreated non-small-cell lung carcinoma. Raymond, E., Burris, H.A., Rowinsky, E.K., Eckardt, J.R., Rodriguez, G., Smith, L., Weiss, G., Von Hoff, D.D. Ann. Oncol. (1997) [Pubmed]
  9. Effect of P-glycoprotein expression on the accumulation and cytotoxicity of topotecan (SK&F 104864), a new camptothecin analogue. Hendricks, C.B., Rowinsky, E.K., Grochow, L.B., Donehower, R.C., Kaufmann, S.H. Cancer Res. (1992) [Pubmed]
  10. Models for placental transfer studies of drugs. Bourget, P., Roulot, C., Fernandez, H. Clinical pharmacokinetics. (1995) [Pubmed]
  11. Solution structure of the low-molecular-weight protein tyrosine phosphatase from Tritrichomonas foetus reveals a flexible phosphate binding loop. Gustafson, C.L., Stauffacher, C.V., Hallenga, K., Van Etten, R.L. Protein Sci. (2005) [Pubmed]
  12. Organotin pollution in deep-sea fish from the northwestern Mediterranean. Borghi, V., Porte, C. Environ. Sci. Technol. (2002) [Pubmed]
  13. Are there different water requirements in different steps of a catalytic cycle? Hydration effects at the E1 and E2 conformers of sarcoplasmic reticulum Ca(2+)-ATPase studied in organic solvents with low amounts of water. Barrabin, H., Scofano, H.M., de Gómez-Puyou, M.T., Gómez-Puyou, A. Eur. J. Biochem. (1993) [Pubmed]
  14. Biosynthesis of the side chain of ubiquinone:trans-prenyltransferase in rat liver microsomes. Teclebrhan, H., Olsson, J., Swiezewska, E., Dallner, G. J. Biol. Chem. (1993) [Pubmed]
  15. Isoprenoid biosynthesis in rat liver mitochondria. Studies on farnesyl pyrophosphate synthase and trans-prenyltransferase. Runquist, M., Ericsson, J., Thelin, A., Chojnacki, T., Dallner, G. J. Biol. Chem. (1994) [Pubmed]
  16. Regulation of coenzyme Q biosynthesis. Appelkvist, E.L., Aberg, F., Guan, Z., Parmryd, I., Dallner, G. Mol. Aspects Med. (1994) [Pubmed]
  17. Different in vitro and in vivo targeting properties of the transit peptide of a chloroplast envelope inner membrane protein. Silva-Filho, M.D., Wieërs, M.C., Flügge, U.I., Chaumont, F., Boutry, M. J. Biol. Chem. (1997) [Pubmed]
  18. Biosynthesis of ubiquinone and plastoquinone in the endoplasmic reticulum-Golgi membranes of spinach leaves. Swiezewska, E., Dallner, G., Andersson, B., Ernster, L. J. Biol. Chem. (1993) [Pubmed]
  19. Flared phacoemulsification tips to decrease ultrasound time and energy in cataract surgery. McNeill, J.I. Journal of cataract and refractive surgery. (2001) [Pubmed]
  20. Sleep disturbances in Japanese patients with Parkinson's disease--comparing with patients in the UK. Abe, K., Hikita, T., Sakoda, S. J. Neurol. Sci. (2005) [Pubmed]
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