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Gene Review

Fdft1  -  farnesyl diphosphate farnesyl transferase 1

Mus musculus

Synonyms: Erg9, FPP:FPP farnesyltransferase, Farnesyl-diphosphate farnesyltransferase, SQS, SS, ...
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Disease relevance of Fdft1


High impact information on Fdft1

  • In phenotypically Slp negative mice the plasma/serum levels of Ss correlate with the C4 activity (P less than 0.001) [4].
  • Treatment of Ss with C1 cleaves a 7,000-8,000-mol wt fragment from the alpha-chain [4].
  • Consistent with this observation, the SREBP-1 -/- animals manifested elevated levels of mRNAs for 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase, farnesyl diphosphate synthase, and squalene synthase [5].
  • In the present study, the squalene synthase inhibitor squalestatin reduced the cholesterol content of cells and prevented the accumulation of PrP(Sc) in three prion-infected cell lines (ScN2a, SMB, and ScGT1 cells) [6].
  • Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis [7].

Biological context of Fdft1


Anatomical context of Fdft1


Associations of Fdft1 with chemical compounds


Other interactions of Fdft1


Analytical, diagnostic and therapeutic context of Fdft1


  1. Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver. Okazaki, H., Tazoe, F., Okazaki, S., Isoo, N., Tsukamoto, K., Sekiya, M., Yahagi, N., Iizuka, Y., Ohashi, K., Kitamine, T., Tozawa, R., Inaba, T., Yagyu, H., Okazaki, M., Shimano, H., Shibata, N., Arai, H., Nagai, R.Z., Kadowaki, T., Osuga, J., Ishibashi, S. J. Lipid Res. (2006) [Pubmed]
  2. In vitro and in vivo activities of E5700 and ER-119884, two novel orally active squalene synthase inhibitors, against Trypanosoma cruzi. Urbina, J.A., Concepcion, J.L., Caldera, A., Payares, G., Sanoja, C., Otomo, T., Hiyoshi, H. Antimicrob. Agents Chemother. (2004) [Pubmed]
  3. Biphenylquinuclidines as inhibitors of squalene synthase and growth of parasitic protozoa. Orenes Lorente, S., Gómez, R., Jiménez, C., Cammerer, S., Yardley, V., de Luca-Fradley, K., Croft, S.L., Ruiz Perez, L.M., Urbina, J., Gonzalez Pacanowska, D., Gilbert, I.H. Bioorg. Med. Chem. (2005) [Pubmed]
  4. Structural and functional differences between the H-2 controlled Ss and Slp proteins. Ferreira, A., Nussenzweig, V., Gigli, I. J. Exp. Med. (1978) [Pubmed]
  5. Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene. Shimano, H., Shimomura, I., Hammer, R.E., Herz, J., Goldstein, J.L., Brown, M.S., Horton, J.D. J. Clin. Invest. (1997) [Pubmed]
  6. Squalestatin cures prion-infected neurons and protects against prion neurotoxicity. Bate, C., Salmona, M., Diomede, L., Williams, A. J. Biol. Chem. (2004) [Pubmed]
  7. Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis. Pandit, J., Danley, D.E., Schulte, G.K., Mazzalupo, S., Pauly, T.A., Hayward, C.M., Hamanaka, E.S., Thompson, J.F., Harwood, H.J. J. Biol. Chem. (2000) [Pubmed]
  8. RPR 101821, a new potent cholesterol-lowering agent: inhibition of squalene synthase and 7-dehydrocholesterol reductase. Amin, D., Rutledge, R.Z., Needle, S.J., Hele, D.J., Neuenswander, K., Bush, R.C., Bilder, G.E., Perrone, M.H. Naunyn Schmiedebergs Arch. Pharmacol. (1996) [Pubmed]
  9. Comparative squalene synthase gene expression in mouse liver and testis. Collins, B.S., Tansey, T.R., Shechter, I. Arch. Biochem. Biophys. (2001) [Pubmed]
  10. Molecular cloning and functional expression of a cDNA for mouse squalene synthase. Inoue, T., Osumi, T., Hata, S. Biochim. Biophys. Acta (1995) [Pubmed]
  11. Animal and plant members of a gene family with similarity to alkaloid-synthesizing enzymes. Fabbri, M., Delp, G., Schmidt, O., Theopold, U. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  12. Embryonic lethality and defective neural tube closure in mice lacking squalene synthase. Tozawa, R., Ishibashi, S., Osuga, J., Yagyu, H., Oka, T., Chen, Z., Ohashi, K., Perrey, S., Shionoiri, F., Yahagi, N., Harada, K., Gotoda, T., Yazaki, Y., Yamada, N. J. Biol. Chem. (1999) [Pubmed]
  13. Squalestatin 1-inducible expression of rat CYP2B: evidence that an endogenous isoprenoid is an activator of the constitutive androstane receptor. Kocarek, T.A., Mercer-Haines, N.A. Mol. Pharmacol. (2002) [Pubmed]
  14. Influence of peroxisome proliferator-activated receptor alpha on ubiquinone biosynthesis. Turunen, M., Peters, J.M., Gonzalez, F.J., Schedin, S., Dallner, G. J. Mol. Biol. (2000) [Pubmed]
  15. Bisphosphonates used for the treatment of bone disorders inhibit squalene synthase and cholesterol biosynthesis. Amin, D., Cornell, S.A., Gustafson, S.K., Needle, S.J., Ullrich, J.W., Bilder, G.E., Perrone, M.H. J. Lipid Res. (1992) [Pubmed]
  16. Lipid-lowering effects of TAK-475, a squalene synthase inhibitor, in animal models of familial hypercholesterolemia. Amano, Y., Nishimoto, T., Tozawa, R., Ishikawa, E., Imura, Y., Sugiyama, Y. Eur. J. Pharmacol. (2003) [Pubmed]
  17. Massive production of farnesol-derived dicarboxylic acids in mice treated with the squalene synthase inhibitor zaragozic acid A. Vaidya, S., Bostedor, R., Kurtz, M.M., Bergstrom, J.D., Bansal, V.S. Arch. Biochem. Biophys. (1998) [Pubmed]
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