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Gene Review

Ubqln1  -  ubiquilin 1

Mus musculus

Synonyms: 1110046H03Rik, 1810030E05Rik, AU019746, C77538, D13Ertd372e, ...
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High impact information on Ubqln1

  • The resulting data revealed the presence of three new putative aggregate-interacting proteins: ubiquilin 1, ubiquilin 2 and Tollip [1].
  • To clarify the molecular mechanism(s) by which DA41 affects cell growth, the effect of DA41 expression on the levels of various cell cycle-regulatory proteins was examined [2].
  • These observations indicate that DA41 is involved in cell cycle regulation in ras-3Y1 cells [2].
  • Fluorescence in situ hybridization (FISH) revealed that DA41 was mapped to human chromosome 9q21.2-q21.3, a position overlapping the candidate tumor suppressor locus for bladder cancer [3].
  • Human DA41 exhibited an 86% amino acid sequence identity to rat DA41, indicating the evolutionarily conserved structure and function of DA41 [3].

Biological context of Ubqln1


Anatomical context of Ubqln1


Analytical, diagnostic and therapeutic context of Ubqln1

  • Immunoprecipitation studies indicated that ubiquilin-1 overexpression decreases ubiquitination of coexpressed PS2 proteins, suggesting that binding of ubiquilin might block ubiquitin chain elongation [4].


  1. Identification of ubiquitin-interacting proteins in purified polyglutamine aggregates. Doi, H., Mitsui, K., Kurosawa, M., Machida, Y., Kuroiwa, Y., Nukina, N. FEBS Lett. (2004) [Pubmed]
  2. Overexpression of DA41 in v-Ha-ras-3Y1 cells causes growth suppression. Ozaki, T., Nakamura, Y., Hanaoka, E., Nakagawara, A., Sakiyama, S. Jpn. J. Cancer Res. (2000) [Pubmed]
  3. Molecular cloning and expression analysis of the human DA41 gene and its mapping to chromosome 9q21.2-q21.3. Hanaoka, E., Ozaki, T., Ohira, M., Nakamura, Y., Suzuki, M., Takahashi, E., Moriya, H., Nakagawara, A., Sakiyama, S. J. Hum. Genet. (2000) [Pubmed]
  4. Overexpression of ubiquilin decreases ubiquitination and degradation of presenilin proteins. Massey, L.K., Mah, A.L., Ford, D.L., Miller, J., Liang, J., Doong, H., Monteiro, M.J. J. Alzheimers Dis. (2004) [Pubmed]
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