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Gene Review

Mpp5  -  membrane protein, palmitoylated 5 (MAGUK...

Mus musculus

Synonyms: 3830420B02Rik, AI255216, AI644496, MAGUK p55 subfamily member 5, Pals1, ...
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High impact information on Mpp5

  • This Drosophila Pals1 homologue has been demonstrated recently to represent Stardust, a crucial polarity gene in Drosophila [1].
  • Pals1 consists of 675 amino acids and maps to mouse chromosome 12 [2].
  • When coexpressed in COS-7 cells, Pals1 co-immunoprecipitates with GAT1 [3].

Analytical, diagnostic and therapeutic context of Mpp5


  1. The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost. Roh, M.H., Makarova, O., Liu, C.J., Shin, K., Lee, S., Laurinec, S., Goyal, M., Wiggins, R., Margolis, B. J. Cell Biol. (2002) [Pubmed]
  2. Molecular cloning and characterization of Pals, proteins associated with mLin-7. Kamberov, E., Makarova, O., Roh, M., Liu, A., Karnak, D., Straight, S., Margolis, B. J. Biol. Chem. (2000) [Pubmed]
  3. The GABA transporter GAT1 and the MAGUK protein Pals1: interaction, uptake modulation, and coexpression in the brain. McHugh, E.M., Zhu, W., Milgram, S., Mager, S. Mol. Cell. Neurosci. (2004) [Pubmed]
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