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Gene Review

mpp5a  -  membrane protein, palmitoylated 5a (MAGUK...

Danio rerio

Synonyms: MAGUK family factor, MAGUK p55 subfamily member 5-A, Nagie oko protein, SO:0000704, mpp5, ...
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High impact information on mpp5

  • Mosaic analysis indicates that the nok retinal patterning phenotype is not cell-autonomous [1].
  • We show that nok encodes a membrane-associated guanylate kinase-family scaffolding protein [1].
  • We propose that nok function in patterning of postmitotic neurons is mediated through neuroepithelial cells and is necessary for guiding neurons to their proper destinations in retinal laminae [1].
  • The zebrafish heart and mind (had) mutation, which disrupts the alpha1B1 subunit of Na(+),K(+) ATPase, causes heart tube elongation defects and other developmental abnormalities that are reminiscent of several epithelial cell polarity mutants, including nagie oko (nok) [2].
  • Heart and soul/PRKCi and nagie oko/Mpp5 regulate myocardial coherence and remodeling during cardiac morphogenesis [3].

Biological context of mpp5

  • This study defines three steps that are required for brain ventricle development and that occur independently of circulation: (1) morphogenesis of the neural tube, requiring nok function; (2) lumen inflation requiring atp1a1a.1 function; and (3) localized cell proliferation [4].

Anatomical context of mpp5

  • Here, by analyzing the adhering properties of photoreceptors in zebrafish N-cad and nok mutants, we demonstrated for the first time that the nok gene is essential for the establishment and/or maintenance of the OLM [5].

Other interactions of mpp5

  • Initial formation of zebrafish brain ventricles occurs independently of circulation and requires the nagie oko and snakehead/atp1a1a.1 gene products [4].


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