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Gene Review

sdt  -  stardust

Drosophila melanogaster

Synonyms: Axin, BP1063, CG12657, CG12658, CG15339, ...
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High impact information on sdt

  • Initially discovered in the landmark genetic screen for Drosophila developmental mutants, bazooka, crumbs, shotgun and stardust mutants exhibit severe disruption in apicobasal polarity in embryonic epithelia, resulting in multilayered epithelia, tissue disintegration, and defects in cuticle formation [1].
  • Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts [1].
  • Here we report that stardust encodes single PDZ domain MAGUK (membrane-associated guanylate kinase) proteins that are expressed in all primary embryonic epithelia from the onset of gastrulation [1].
  • The Stardust proteins represent versatile candidates as structural and possibly regulatory constituents of the SAC, a crucial element in the control of epithelial cell polarity [2].
  • Cells lacking crumbs or the functionally related gene stardust fail to organize a continuous ZA and to maintain cell polarity [2].

Biological context of sdt


Anatomical context of sdt


Associations of sdt with chemical compounds

  • We provide evidence that the genes crumbs (crb) and stardust (sdt) encode critical components of a pathway that acts at the apical pole of epithelial cells to control the cytoarchitecture of ectodermally derived epithelia of the Drosophila embryo [3].

Physical interactions of sdt

  • Drosophila PATJ or Drosophila Lin-7 are stabilised whenever a Sdt variant that contains the respective binding site is present, independently of where the variant is localised [9].

Co-localisations of sdt

  • Stardust colocalizes with Crumbs at the apicolateral boundary, although their expression patterns in sensory organs differ [1].

Other interactions of sdt


  1. Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts. Hong, Y., Stronach, B., Perrimon, N., Jan, L.Y., Jan, Y.N. Nature (2001) [Pubmed]
  2. Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity. Bachmann, A., Schneider, M., Theilenberg, E., Grawe, F., Knust, E. Nature (2001) [Pubmed]
  3. Crumbs and stardust act in a genetic pathway that controls the organization of epithelia in Drosophila melanogaster. Tepass, U., Knust, E. Dev. Biol. (1993) [Pubmed]
  4. The Drosophila genes crumbs and stardust are involved in the biogenesis of adherens junctions. Grawe, F., Wodarz, A., Lee, B., Knust, E., Skaer, H. Development (1996) [Pubmed]
  5. PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells. Michel, D., Arsanto, J.P., Massey-Harroche, D., Béclin, C., Wijnholds, J., Le Bivic, A. J. Cell. Sci. (2005) [Pubmed]
  6. Distinct roles of Bazooka and Stardust in the specification of Drosophila photoreceptor membrane architecture. Hong, Y., Ackerman, L., Jan, L.Y., Jan, Y.N. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  7. armadillo, bazooka, and stardust are critical for early stages in formation of the zonula adherens and maintenance of the polarized blastoderm epithelium in Drosophila. Müller, H.A., Wieschaus, E. J. Cell Biol. (1996) [Pubmed]
  8. The Drosophila cell survival gene discs lost encodes a cytoplasmic Codanin-1-like protein, not a homolog of tight junction PDZ protein Patj. Pielage, J., Stork, T., Bunse, I., Klämbt, C. Dev. Cell (2003) [Pubmed]
  9. Multiple domains of Stardust differentially mediate localisation of the Crumbs-Stardust complex during photoreceptor development in Drosophila. Bulgakova, N.A., Kempkens, O., Knust, E. J. Cell. Sci. (2008) [Pubmed]
  10. Computer modelling in combination with in vitro studies reveals similar binding affinities of Drosophila Crumbs for the PDZ domains of Stardust and DmPar-6. Kempkens, O., Médina, E., Fernandez-Ballester, G., Ozüyaman, S., Le Bivic, A., Serrano, L., Knust, E. Eur. J. Cell Biol. (2006) [Pubmed]
  11. DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila. Sotillos, S., Díaz-Meco, M.T., Caminero, E., Moscat, J., Campuzano, S. J. Cell Biol. (2004) [Pubmed]
  12. Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1). Makarova, O., Roh, M.H., Liu, C.J., Laurinec, S., Margolis, B. Gene (2003) [Pubmed]
  13. Embryonic origin of hemocytes and their relationship to cell death in Drosophila. Tepass, U., Fessler, L.I., Aziz, A., Hartenstein, V. Development (1994) [Pubmed]
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