The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

MPP5  -  membrane protein, palmitoylated 5 (MAGUK...

Homo sapiens

Synonyms: FLJ12615, MAGUK p55 subfamily member 5, PALS1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on MPP5

  • Similarly, overexpression of Par6 in MDCK cells inhibits localization of PALS1 to the tight junction [1].
  • One of these protein complexes is the PATJ/PALS1/Crumbs tripartite complex, which is crucial for the establishment and maintenance of cell polarity [2].
  • Mammalian Lin-7 forms a complex with several proteins, including PALS1, that have a role in polarity determination in epithelial cells [3].
  • Taken together, these results indicate that Lin-7 functions in tight junction formation by stabilizing its membrane-associated guanylate kinase binding partner PALS1 [3].
  • Furthermore, exogenously expressed PALS1, but not other Lin-7 binding partners, also rescued the effects of Lin-7 knock down, including the restoration of PATJ protein in rescued cell lines [3].

Biological context of MPP5

  • Autoimmunity induced by the graft-versus-host reaction is an experimental model that illustrates this potential mechanism (A. G. Rolink, S. T. Pals, and E. Gleichmann, J. Exp. Med. 157, 755, 1983; R. A. Eisenberg, S. Y. Craven, and P. L. Cohen, Arth. Rheum. 26, S19, 1983) [4].

Anatomical context of MPP5


Physical interactions of MPP5


Co-localisations of MPP5

  • Localization studies in human retinae revealed that MPP3 colocalized with MPP5 and CRB1 at the subapical region [7].

Other interactions of MPP5

  • Localization studies in the retina showed that CRB1, MPP5, and MPP4 colocalize at the outer limiting membrane (OLM) [8].
  • The knock down of Lin-7 also resulted in the loss of expression of several Lin-7 binding partners, including PALS1 and the polarity protein PATJ [3].
  • MPP3 is recruited to the MPP5 protein scaffold at the retinal outer limiting membrane [7].
  • Finally, our study demonstrates the essential role of ezrin-PALS1 interaction in the apical membrane remodeling associated with parietal cell secretion [6].

Analytical, diagnostic and therapeutic context of MPP5


  1. Direct interaction of two polarity complexes implicated in epithelial tight junction assembly. Hurd, T.W., Gao, L., Roh, M.H., Macara, I.G., Margolis, B. Nat. Cell Biol. (2003) [Pubmed]
  2. Structural basis for L27 domain-mediated assembly of signaling and cell polarity complexes. Li, Y., Karnak, D., Demeler, B., Margolis, B., Lavie, A. EMBO J. (2004) [Pubmed]
  3. Mammalian lin-7 stabilizes polarity protein complexes. Straight, S.W., Pieczynski, J.N., Whiteman, E.L., Liu, C.J., Margolis, B. J. Biol. Chem. (2006) [Pubmed]
  4. Class II major histocompatibility antigens and the etiology of systemic lupus erythematosus. Eisenberg, R.A., Cohen, P.L. Clin. Immunol. Immunopathol. (1983) [Pubmed]
  5. Membrane-associated guanylate kinase proteins MPP4 and MPP5 associate with Veli3 at distinct intercellular junctions of the neurosensory retina. Stöhr, H., Molday, L.L., Molday, R.S., Weber, B.H., Biedermann, B., Reichenbach, A., Krämer, F. J. Comp. Neurol. (2005) [Pubmed]
  6. PALS1 specifies the localization of ezrin to the apical membrane of gastric parietal cells. Cao, X., Ding, X., Guo, Z., Zhou, R., Wang, F., Long, F., Wu, F., Bi, F., Wang, Q., Fan, D., Forte, J.G., Teng, M., Yao, X. J. Biol. Chem. (2005) [Pubmed]
  7. MPP3 is recruited to the MPP5 protein scaffold at the retinal outer limiting membrane. Kantardzhieva, A., Alexeeva, S., Versteeg, I., Wijnholds, J. FEBS J. (2006) [Pubmed]
  8. MPP5 recruits MPP4 to the CRB1 complex in photoreceptors. Kantardzhieva, A., Gosens, I., Alexeeva, S., Punte, I.M., Versteeg, I., Krieger, E., Neefjes-Mol, C.A., den Hollander, A.I., Letteboer, S.J., Klooster, J., Cremers, F.P., Roepman, R., Wijnholds, J. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
WikiGenes - Universities