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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Arpc3  -  actin related protein 2/3 complex, subunit 3

Mus musculus

Synonyms: 1110006A04Rik, 21kDa, AA408672, AI788639, Actin-related protein 2/3 complex subunit 3, ...
 
 
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High impact information on Arpc3

  • Sleeping beauty transposon-based phenotypic analysis of mice: lack of Arpc3 results in defective trophoblast outgrowth [1].
  • In vitro blastocyst culture of Arpc3 mutants exhibited severe spreading impairment of trophoblasts [1].
  • Arpc3 is a component of the Arp2/3 complex, which plays a major role in actin nucleation with Y-shaped branching from the mother actin filament in response to migration signaling [1].
  • Cultured primary DRG neurons also express Sox11 and treatment with Sox11 small interfering RNA (siRNA) caused a significant decrease in neurite growth and branching and a decrease in mRNA encoding actin-related protein complex 3 (Arpc3), an actin organizing protein that may be involved in axon growth [2].
 

Anatomical context of Arpc3

References

  1. Sleeping beauty transposon-based phenotypic analysis of mice: lack of Arpc3 results in defective trophoblast outgrowth. Yae, K., Keng, V.W., Koike, M., Yusa, K., Kouno, M., Uno, Y., Kondoh, G., Gotow, T., Uchiyama, Y., Horie, K., Takeda, J. Mol. Cell. Biol. (2006) [Pubmed]
  2. SRY-box containing gene 11 (Sox11) transcription factor is required for neuron survival and neurite growth. Jankowski, M.P., Cornuet, P.K., McIlwrath, S., Koerber, H.R., Albers, K.M. Neuroscience (2006) [Pubmed]
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