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Gene Review

Sox11  -  SRY (sex determining region Y)-box 11

Mus musculus

Synonyms: 1110038H03Rik, 6230403H02Rik, AI836553, Sox-11, Transcription factor SOX-11, ...
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Disease relevance of Sox11


High impact information on Sox11


Biological context of Sox11

  • Sox4 shows a high degree of sequence homology with another group C Sox gene, Sox11, which is predominantly expressed in the CNS [4].
  • Structure function analysis revealed that Sox11 has a strong intrinsic transactivation capacity which is mediated by a transactivation domain in its carboxyl-terminal part [3].
  • RNA expression analysis showed that Sox11 knockdown modulated the level of mRNAs encoding several genes related to cell survival and death [2].
  • Similar to Neuro2a cells, a decrease in TANK gene expression occurred, suggesting at least some overlap in Sox11 transcriptional targets in Neuro2a and DRG neurons [2].

Anatomical context of Sox11

  • Expression of Sox11 was found in the mesenchyme surrounding the pancreatic buds, whereas Sox4 and Sox9 were confined to the pancreatic epithelium and later to islets [5].
  • As development proceeded, their expression always appeared to relate to the maturational stage of the cell population, with Sox11 expression more transient than Sox4, except in the spinal cord where the reverse was true [4].
  • In agreement with its expression in neural precursors, Sox11 levels in cells of the oligodendrocyte lineage were high in precursors and down-regulated during terminal differentiation [3].
  • These data are consistent with a central role for Sox11 in regulating events that promote neurite growth and neuron survival [2].
  • Results show Sox11 has an essential role in regulation of neuron survival and neurite outgrowth in Neuro2a cells and primary sensory neurons [2].

Associations of Sox11 with chemical compounds

  • RNAi-mediated knockdown of Sox11 in RA-differentiated Neuro2a cells caused a decrease in neurite growth and an increase in the percent of apoptotic cells [2].
  • Following addition of 20 muM retinoic acid (RA), a stimulus for differentiation that enhances neurite growth and differentiation, Sox11 level rises [2].

Physical interactions of Sox11

  • Cultured primary DRG neurons also express Sox11 and treatment with Sox11 small interfering RNA (siRNA) caused a significant decrease in neurite growth and branching and a decrease in mRNA encoding actin-related protein complex 3 (Arpc3), an actin organizing protein that may be involved in axon growth [2].

Other interactions of Sox11

  • To identify the transcription factor(s) binding to these elements, we conducted one-hybrid screening and identified Dlx5 and Sox11 [6].
  • Both Dlx5 and Sox11 are expressed in the AER, and the proteins encoded by these genes bind to separate conserved elements, supporting their possible roles in regulating Msx2 expression [6].

Analytical, diagnostic and therapeutic context of Sox11


  1. Gene targeting reveals a widespread role for the high-mobility-group transcription factor Sox11 in tissue remodeling. Sock, E., Rettig, S.D., Enderich, J., Bösl, M.R., Tamm, E.R., Wegner, M. Mol. Cell. Biol. (2004) [Pubmed]
  2. SRY-box containing gene 11 (Sox11) transcription factor is required for neuron survival and neurite growth. Jankowski, M.P., Cornuet, P.K., McIlwrath, S., Koerber, H.R., Albers, K.M. Neuroscience (2006) [Pubmed]
  3. Cooperative function of POU proteins and SOX proteins in glial cells. Kuhlbrodt, K., Herbarth, B., Sock, E., Enderich, J., Hermans-Borgmeyer, I., Wegner, M. J. Biol. Chem. (1998) [Pubmed]
  4. Roles of Sox4 in central nervous system development. Cheung, M., Abu-Elmagd, M., Clevers, H., Scotting, P.J. Brain Res. Mol. Brain Res. (2000) [Pubmed]
  5. Expression of Sox transcription factors in the developing mouse pancreas. Lioubinski, O., Müller, M., Wegner, M., Sander, M. Dev. Dyn. (2003) [Pubmed]
  6. Transcriptional regulation of Msx2 in the AERs of developing limbs is dependent on multiple closely spaced regulatory elements. Cheng, H.C., Wang, C.K., Upholt, W.B. Dev. Biol. (2004) [Pubmed]
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