Gene Review:
MGP - matrix Gla protein
Homo sapiens
Synonyms:
Cell growth-inhibiting gene 36 protein, GIG36, MGLAP, Matrix Gla protein, NTI
Boot-Handford,
Sardella,
Canfield,
Nishimoto,
Wallin,
Pierantozzi,
Munroe,
Van Maldergem,
Ballanti,
Balducci,
Sane,
Ketteler,
Nishimoto,
Coen,
Roberts,
Yuksel,
Kumar,
Farrington,
Mantella,
Floege,
Cain,
Chung,
Olgunturk,
Hutson,
Manni,
Vermeer,
Ruggeri,
Grandi,
Jahnen-Dechent,
Dziobon,
L.J. Schurgers,
H. M. H. Spronk,
J.N. Skepper,
T.M. Hackeng,
C.M. Shanahan,
C. Vermeer,
P.L. Weissberg,
D. Proudfoot,
Heagerty,
Bonucci,
Sorbo,
Wanner,
Fryns,
Ziereisen,
Loeser,
Gardiner,
Westenfeld,
- The involvement of matrix glycoproteins in vascular calcification and fibrosis: an immunohistochemical study. Canfield, A.E., Farrington, C., Dziobon, M.D., Boot-Handford, R.P., Heagerty, A.M., Kumar, S.N., Roberts, I.S. J. Pathol. (2002)
- Renal osteodystrophy: alpha-Heremans Schmid glycoprotein/fetuin-A, matrix GLA protein serum levels, and bone histomorphometry. Coen, G., Ballanti, P., Balducci, A., Grandi, F., Manni, M., Mantella, D., Pierantozzi, A., Ruggeri, M., Sardella, D., Sorbo, G., Bonucci, E. Am. J. Kidney Dis. (2006)
- Processing and transport of matrix gamma-carboxyglutamic acid protein and bone morphogenetic protein-2 in cultured human vascular smooth muscle cells: evidence for an uptake mechanism for serum fetuin. Wajih, N., Borras, T., Xue, W., Hutson, S.M., Wallin, R. J. Biol. Chem. (2004)
- Overexpression of matrix Gla protein mRNA in malignant human breast cells: isolation by differential cDNA hybridization. Chen, L., O'Bryan, J.P., Smith, H.S., Liu, E. Oncogene (1990)
- Memantine. Merz. Kilpatrick, G.J., Tilbrook, G.S. Current opinion in investigational drugs (London, England : 2000) (2002)
- Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome. Munroe, P.B., Olgunturk, R.O., Fryns, J.P., Van Maldergem, L., Ziereisen, F., Yuksel, B., Gardiner, R.M., Chung, E. Nat. Genet. (1999)
- High expression of genes for calcification-regulating proteins in human atherosclerotic plaques. Shanahan, C.M., Cary, N.R., Metcalfe, J.C., Weissberg, P.L. J. Clin. Invest. (1994)
- Identification of a novel negative retinoic acid responsive element in the promoter of the human matrix Gla protein gene. Kirfel, J., Kelter, M., Cancela, L.M., Price, P.A., Schüle, R. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Oral anticoagulant treatment: friend or foe in cardiovascular disease? Schurgers, L.J., Aebert, H., Vermeer, C., Bültmann, B., Janzen, J. Blood (2004)
- Regulation of Bone Morphogenetic Protein-4 by Matrix GLA Protein in Vascular Endothelial Cells Involves Activin-like Kinase Receptor 1. Yao, Y., Zebboudj, A.F., Shao, E., Perez, M., Bostr??m, K. J. Biol. Chem. (2006)
- Differential regulation of matrix Gla protein (MGP) gene expression by retinoic acid and estrogen in human breast carcinoma cells. Sheikh, M.S., Shao, Z.M., Chen, J.C., Fontana, J.A. Mol. Cell. Endocrinol. (1993)
- The antimicrobial efficacy of 'MGP' gutta-percha in vitro. Shur, A.L., Sedgley, C.M., Fenno, J.C. International endodontic journal. (2003)
- Clinical review 86: Euthyroid sick syndrome: is it a misnomer? Chopra, I.J. J. Clin. Endocrinol. Metab. (1997)
- Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene. Cancela, L., Hsieh, C.L., Francke, U., Price, P.A. J. Biol. Chem. (1990)
- Modulation of the binding of matrix Gla protein (MGP) to bone morphogenetic protein-2 (BMP-2). Wallin, R., Cain, D., Hutson, S.M., Sane, D.C., Loeser, R. Thromb. Haemost. (2000)
- Excess magnesium inhibits excess calcium-induced matrix-mineralization and production of matrix gla protein (MGP) by ATDC5 cells. Nakatani, S., Mano, H., Ryanghyok, I.M., Shimizu, J., Wada, M. Biochem. Biophys. Res. Commun. (2006)
- Genes expressed in the human trabecular meshwork during pressure-induced homeostatic response. Vittitow, J., Borrás, T. J. Cell. Physiol. (2004)
- Regulatory role of endothelium in the expression of genes affecting arterial calcification. Cola, C., Almeida, M., Li, D., Romeo, F., Mehta, J.L. Biochem. Biophys. Res. Commun. (2004)
- Purification of matrix Gla protein from a marine teleost fish, Argyrosomus regius: calcified cartilage and not bone as the primary site of MGP accumulation in fish. Simes, D.C., Williamson, M.K., Ortiz-Delgado, J.B., Viegas, C.S., Price, P.A., Cancela, M.L. J. Bone Miner. Res. (2003)
- Gla-containing proteins of bone. Price, P.A. Connect. Tissue Res. (1989)
- Articular-cartilage matrix gamma-carboxyglutamic acid-containing protein. Characterization and immunolocalization. Loeser, R., Carlson, C.S., Tulli, H., Jerome, W.G., Miller, L., Wallin, R. Biochem. J. (1992)
- Novel insights into uremic vascular calcification: role of matrix Gla protein and alpha-2-Heremans Schmid glycoprotein/fetuin. Ketteler, M., Vermeer, C., Wanner, C., Westenfeld, R., Jahnen-Dechent, W., Floege, J. Blood Purif. (2002)
- Post-translational modifications regulate matrix Gla protein function: importance for inhibition of vascular smooth muscle cell calcification. Schurgers, L.J., Spronk, H.M., Skepper, J.N., Hackeng, T.M., Shanahan, C.M., Vermeer, C., Weissberg, P.L., Proudfoot, D. J. Thromb. Haemost. (2007)
- Matrix Gla protein C-terminal region binds to vitronectin. Co-localization suggests binding occurs during tissue development. Nishimoto, S.K., Nishimoto, M. Matrix Biol. (2005)
- Matrix GLA protein function in human trabecular meshwork cells: inhibition of BMP2-induced calcification process. Xue, W., Wallin, R., Olmsted-Davis, E.A., Borrás, T. Invest. Ophthalmol. Vis. Sci. (2006)
- Differential effects of transforming growth factor-beta 1 and bone morphogenetic protein 4 on gene expression and differentiated function of preosteoblasts. Zhou, H., Hammonds, R.G., Findlay, D.M., Martin, T.J., Ng, K.W. J. Cell. Physiol. (1993)
- Matrix Gla protein (MGP) and bone morphogenetic protein-2 in aortic calcified lesions of aging rats. Sweatt, A., Sane, D.C., Hutson, S.M., Wallin, R. J. Thromb. Haemost. (2003)
- Retinoic acid modulation of mRNA levels in malignant, nontransformed, and immortalized osteoblasts. Zhou, H., Hammonds, R.G., Findlay, D.M., Fuller, P.J., Martin, T.J., Ng, K.W. J. Bone Miner. Res. (1991)