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Gene Review:

Rab9 - RAB9, member RAS oncogene family

Mus musculus

Synonyms: 2410064E05Rik, AI195561, Rab9a, Ras-related protein Rab-9A, SID 99, ...

Hashim, S. et al., von Delwig, A. et al., Riederer, M.A. et al.

von Delwig, Musson, Shim, Lee, Walker, Harding, Williamson, Robinson,

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Disease relevance of Rab9

Expression of Rab9 protein in Escherichia coli: purification and isoprenylation in vitro [1].

High impact information on Rab9

Retention of Rab5 and Rab18 and selective depletion of Rab7 and Rab9 presumably enable the LSP to avoid transport to lysosomes through late endosomes [2].
In contrast, live Salmonella-containing phagosomes (LSP) retain a significant amount of Rab5 and transferrin receptor until 30 min, selectively deplete Rab7 and Rab9, and never acquire mannose 6-phosphate receptors even 90 min after internalization [2].

Biological context of Rab9

No productive antigen-processing activity was associated with fractions of intermediate density expressing Rab7 and Rab9, characteristic of late endosomes [3].

References

Expression of Rab9 protein in Escherichia coli: purification and isoprenylation in vitro. Riederer, M.A., Soldati, T., Dirac-Svejstrup, A.B., Pfeffer, S.R. Meth. Enzymol. (1995) [Pubmed]
Live Salmonella modulate expression of Rab proteins to persist in a specialized compartment and escape transport to lysosomes. Hashim, S., Mukherjee, K., Raje, M., Basu, S.K., Mukhopadhyay, A. J. Biol. Chem. (2000) [Pubmed]
Distribution of productive antigen-processing activity for MHC class II presentation in macrophages. von Delwig, A., Musson, J.A., Shim, H.K., Lee, J.J., Walker, N., Harding, C.V., Williamson, E.D., Robinson, J.H. Scand. J. Immunol. (2005) [Pubmed]

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RAB9A	Bos taurus
RAB9A	Canis lupus familiaris
rab9a	Danio rerio
RAB9A	Gallus gallus
RAB9A	Homo sapiens
RAB9A	Macaca mulatta
RAB9A	Pan troglodytes
Rab9a	Rattus norvegicus
rab9a	Xenopus (Silurana) tropicalis

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