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Gene Review

Rab18  -  RAB18, member RAS oncogene family

Mus musculus

Synonyms: AA959686, Ras-related protein Rab-18
 
 
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High impact information on Rab18

  • In addition, association with the LD surface was increased following stimulation of lipolysis and inhibited by a caveolin mutant suggesting that recruitment of Rab18 is regulated by the metabolic state of individual LDs [1].
  • To gain insights into this specific localization, Rab18 was co-expressed with Cav3DGV, a truncation mutant of caveolin-3 shown to inhibit the catabolism and motility of lipid droplets [1].
  • In both adipocytes and non-adipocyte cell lines Rab18 localized to a subset of LDs [1].
  • Moreover, in 3T3-L1 adipocytes, stimulation of lipolysis increased the localization of Rab18 to LDs, an effect reversed by beta-adrenergic antagonists [1].
  • Consistent with this observation, overexpression of Rab18 induced a decrease in the amounts of ADRP in LDs in HepG2 and BALB/c 3T3 cells [2].
 

Biological context of Rab18

 

Analytical, diagnostic and therapeutic context of Rab18

References

  1. Regulated localization of Rab18 to lipid droplets: effects of lipolytic stimulation and inhibition of lipid droplet catabolism. Martin, S., Driessen, K., Nixon, S.J., Zerial, M., Parton, R.G. J. Biol. Chem. (2005) [Pubmed]
  2. Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane. Ozeki, S., Cheng, J., Tauchi-Sato, K., Hatano, N., Taniguchi, H., Fujimoto, T. J. Cell. Sci. (2005) [Pubmed]
  3. Rab17 and rab18, small GTPases with specificity for polarized epithelial cells: genetic mapping in the mouse. McMurtrie, E.B., Barbosa, M.D., Zerial, M., Kingsmore, S.F. Genomics (1997) [Pubmed]
  4. Gene cloning and characterization of a GTP-binding Rab protein from mouse pituitary AtT-20 cells. Yu, H., Leaf, D.S., Moore, H.P. Gene (1993) [Pubmed]
 
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