The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Rab18  -  RAB18, member RAS oncogene family

Mus musculus

Synonyms: AA959686, Ras-related protein Rab-18
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Rab18

  • In addition, association with the LD surface was increased following stimulation of lipolysis and inhibited by a caveolin mutant suggesting that recruitment of Rab18 is regulated by the metabolic state of individual LDs [1].
  • To gain insights into this specific localization, Rab18 was co-expressed with Cav3DGV, a truncation mutant of caveolin-3 shown to inhibit the catabolism and motility of lipid droplets [1].
  • In both adipocytes and non-adipocyte cell lines Rab18 localized to a subset of LDs [1].
  • Moreover, in 3T3-L1 adipocytes, stimulation of lipolysis increased the localization of Rab18 to LDs, an effect reversed by beta-adrenergic antagonists [1].
  • Consistent with this observation, overexpression of Rab18 induced a decrease in the amounts of ADRP in LDs in HepG2 and BALB/c 3T3 cells [2].

Biological context of Rab18


Analytical, diagnostic and therapeutic context of Rab18


  1. Regulated localization of Rab18 to lipid droplets: effects of lipolytic stimulation and inhibition of lipid droplet catabolism. Martin, S., Driessen, K., Nixon, S.J., Zerial, M., Parton, R.G. J. Biol. Chem. (2005) [Pubmed]
  2. Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane. Ozeki, S., Cheng, J., Tauchi-Sato, K., Hatano, N., Taniguchi, H., Fujimoto, T. J. Cell. Sci. (2005) [Pubmed]
  3. Rab17 and rab18, small GTPases with specificity for polarized epithelial cells: genetic mapping in the mouse. McMurtrie, E.B., Barbosa, M.D., Zerial, M., Kingsmore, S.F. Genomics (1997) [Pubmed]
  4. Gene cloning and characterization of a GTP-binding Rab protein from mouse pituitary AtT-20 cells. Yu, H., Leaf, D.S., Moore, H.P. Gene (1993) [Pubmed]
WikiGenes - Universities