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Gene Review

Rab7  -  RAB7, member RAS oncogene family

Mus musculus

Synonyms: Rab7a, Ras-related protein Rab-7a
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Disease relevance of Rab7


High impact information on Rab7


Biological context of Rab7


Anatomical context of Rab7

  • Role for Rab7 in maturation of late autophagic vacuoles [11].
  • The expression of Rab7 was obviously increased in the hepatic tissues, especially in the endothelial cells and hepatocytes around central veins of the high cholesterol-fed rabbit, compared to the tissues from rabbit fed a normal diet [2].
  • Thus two Rab proteins regulate two different motor proteins, thereby controlling complementary phases in melanosome biogenesis: Rab7 controls microtubule-mediated transport of early and Rab27a the subsequent actin-dependent transport of mature melanosomes [12].
  • A cDNA clone coding for the Rab7 protein was isolated from an NIH3T3 cell line (mouse fibroblasts) cDNA library [13].
  • Here we report that removal of the carboxyl-terminal acidic Pro(505)AspGluAsnAsp(509) sequence prevents the storage of GLUT4 in the VAMP-2 positive compartment adjacent to the Golgi complex (GSC), and results in its targeting to GLUT4-positive vesicles and Rab7-positive late endosomes [14].

Associations of Rab7 with chemical compounds

  • Lm escaped from Rab5a-negative, lysosome-associated membrane protein-1 (LAMP1)-negative, Rab7-positive, phosphatidylinositol 3-phosphate [PI(3)P]-positive vacuoles [15].
  • Rab7 gene is up-regulated by cholesterol-rich diet in the liver and artery [2].
  • Nevertheless, despite acquisition of wild-type or constitutively active Rab7, both the L. pneumophila and the M. tuberculosis phagosomes continue to exhibit altered maturation as manifested by a failure to acquire lysosome-associated membrane glycoprotein 1 [5].
  • In growth factor-deprived cells, however, blocking Rab7 function prevented the clearance of glucose and amino acid transporter proteins from the cell surface [16].

Other interactions of Rab7


Analytical, diagnostic and therapeutic context of Rab7

  • By radiation hybrid mapping, we have located the human RAB7 gene on Chr 3, in a region homologous to the mouse Chr 6, where the Rab7 gene maps [10].
  • Our experiments with quantitative electron microscopy showed that Rab7 was not needed for the initial maturation of early autophagosomes to late autophagic vacuoles, but that it participated in the final maturation of late autophagic vacuoles [11].
  • Molecular cloning and expression analysis of the human Rab7 GTP-ase complementary deoxyribonucleic acid [21].
  • To visualize the location of elevated Rab7 expression in tissues, patterns of the gene expression were monitored within hepatic and aortic tissues by in situ hybridization and immunohistochemistry [2].
  • Western blot analysis reveals reduced Rab5 and enhanced Rab7 content in the maleylated bovine serum albumin-MDP (MBSA-MDP)-treated cells [3].


  1. PU.1 Redirects Adenovirus to Lysosomes in Alveolar Macrophages, Uncoupling Internalization from Infection. Carey, B., Staudt, M.K., Bonaminio, D., van der Loo, J.C., Trapnell, B.C. J. Immunol. (2007) [Pubmed]
  2. Rab7 gene is up-regulated by cholesterol-rich diet in the liver and artery. Kim, J.Y., Jang, M.K., Lee, S.S., Choi, M.S., Bok, S.H., Oh, G.T., Park, Y.B. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  3. Diverting intracellular trafficking of Salmonella to the lysosome through activation of the late endocytic Rab7 by intracellular delivery of muramyl dipeptide. Mukherjee, K., Parashuraman, S., Krishnamurthy, G., Majumdar, J., Yadav, A., Kumar, R., Basu, S.K., Mukhopadhyay, A. J. Cell. Sci. (2002) [Pubmed]
  4. Mouse polyomavirus utilizes recycling endosomes for a traffic pathway independent of COPI vesicle transport. Mannová, P., Forstová, J. J. Virol. (2003) [Pubmed]
  5. Mycobacterium tuberculosis and Legionella pneumophila phagosomes exhibit arrested maturation despite acquisition of Rab7. Clemens, D.L., Lee, B.Y., Horwitz, M.A. Infect. Immun. (2000) [Pubmed]
  6. IL-6 and IL-12 specifically regulate the expression of Rab5 and Rab7 via distinct signaling pathways. Bhattacharya, M., Ojha, N., Solanki, S., Mukhopadhyay, C.K., Madan, R., Patel, N., Krishnamurthy, G., Kumar, S., Basu, S.K., Mukhopadhyay, A. EMBO J. (2006) [Pubmed]
  7. Structural basis for recruitment of RILP by small GTPase Rab7. Wu, M., Wang, T., Loh, E., Hong, W., Song, H. EMBO J. (2005) [Pubmed]
  8. Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules. Christensen, E.I., Devuyst, O., Dom, G., Nielsen, R., Van der Smissen, P., Verroust, P., Leruth, M., Guggino, W.B., Courtoy, P.J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  9. Modulation of Rab5 and Rab7 recruitment to phagosomes by phosphatidylinositol 3-kinase. Vieira, O.V., Bucci, C., Harrison, R.E., Trimble, W.S., Lanzetti, L., Gruenberg, J., Schreiber, A.D., Stahl, P.D., Grinstein, S. Mol. Cell. Biol. (2003) [Pubmed]
  10. Genetic mapping of the mouse Rab7 gene and pseudogene and of the human RAB7 homolog. Chiariello, M., De Gregorio, L., Vitelli, R., Alifano, P., Dragani, T.A., Bruni, C.B., Bucci, C. Mamm. Genome (1998) [Pubmed]
  11. Role for Rab7 in maturation of late autophagic vacuoles. Jäger, S., Bucci, C., Tanida, I., Ueno, T., Kominami, E., Saftig, P., Eskelinen, E.L. J. Cell. Sci. (2004) [Pubmed]
  12. Rab7 and Rab27a control two motor protein activities involved in melanosomal transport. Jordens, I., Westbroek, W., Marsman, M., Rocha, N., Mommaas, M., Huizing, M., Lambert, J., Naeyaert, J.M., Neefjes, J. Pigment Cell Res. (2006) [Pubmed]
  13. Cloning and expression analysis of the murine Rab7 cDNA. Vitelli, R., Chiariello, M., Bruni, C.B., Bucci, C. Biochim. Biophys. Acta (1995) [Pubmed]
  14. Intracellular targeting and retention of the glucose transporter GLUT4 by the perinuclear storage compartment involves distinct carboxyl-tail motifs. Martinez-Arca, S., Lalioti, V.S., Sandoval, I.V. J. Cell. Sci. (2000) [Pubmed]
  15. Cytolysin-dependent delay of vacuole maturation in macrophages infected with Listeria monocytogenes. Henry, R., Shaughnessy, L., Loessner, M.J., Alberti-Segui, C., Higgins, D.E., Swanson, J.A. Cell. Microbiol. (2006) [Pubmed]
  16. Rab7 prevents growth factor-independent survival by inhibiting cell-autonomous nutrient transporter expression. Edinger, A.L., Cinalli, R.M., Thompson, C.B. Dev. Cell (2003) [Pubmed]
  17. Live Salmonella modulate expression of Rab proteins to persist in a specialized compartment and escape transport to lysosomes. Hashim, S., Mukherjee, K., Raje, M., Basu, S.K., Mukhopadhyay, A. J. Biol. Chem. (2000) [Pubmed]
  18. beta-Arrestin 1 participates in platelet-activating factor receptor-mediated endocytosis of Streptococcus pneumoniae. Radin, J.N., Orihuela, C.J., Murti, G., Guglielmo, C., Murray, P.J., Tuomanen, E.I. Infect. Immun. (2005) [Pubmed]
  19. The loss of the chloride channel, ClC-5, delays apical iodide efflux and induces a euthyroid goiter in the mouse thyroid gland. van den Hove, M.F., Croizet-Berger, K., Jouret, F., Guggino, S.E., Guggino, W.B., Devuyst, O., Courtoy, P.J. Endocrinology (2006) [Pubmed]
  20. Mycobacterium's arrest of phagosome maturation in macrophages requires Rab5 activity and accessibility to iron. Kelley, V.A., Schorey, J.S. Mol. Biol. Cell (2003) [Pubmed]
  21. Molecular cloning and expression analysis of the human Rab7 GTP-ase complementary deoxyribonucleic acid. Vitelli, R., Chiariello, M., Lattero, D., Bruni, C.B., Bucci, C. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
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