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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NIT2  -  nitrilase family, member 2

Homo sapiens

Synonyms: CUA002, Nitrilase homolog 2, Omega-amidase NIT2
 
 
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High impact information on NIT2

  • The predicted CLNR1 protein exhibits high amino acid sequence similarities with the AREA and NIT2 global fungal nitrogen regulators [1].
  • In the 5' flanking region of the gene for Fd VI only, we identified NIT-2 motifs, which are widely found in genes for enzymes related to nitrogen metabolism [2].
  • NIT2 binding sites in the promoter region of the nit-3, alc, and lao genes are very different in sequence context except for the presence of at least two copies of a GATA core sequence [3].
  • DNA recognition by the NIT2 nitrogen regulatory protein: importance of the number, spacing, and orientation of GATA core elements and their flanking sequences upon NIT2 binding [3].
  • The protein contains a putative zinc finger DNA-binding domain that shares 98% amino acid identity with the zinc finger of the major nitrogen regulatory proteins AREA and NIT2 of Aspergillus nidulans and Neurospora crassa, respectively [4].
 

Biological context of NIT2

References

  1. CLNR1, the AREA/NIT2-like global nitrogen regulator of the plant fungal pathogen Colletotrichum lindemuthianum is required for the infection cycle. Pellier, A.L., Laugé, R., Veneault-Fourrey, C., Langin, T. Mol. Microbiol. (2003) [Pubmed]
  2. A nitrate-inducible ferredoxin in maize roots. Genomic organization and differential expression of two nonphotosynthetic ferredoxin isoproteins. Matsumura, T., Sakakibara, H., Nakano, R., Kimata, Y., Sugiyama, T., Hase, T. Plant Physiol. (1997) [Pubmed]
  3. DNA recognition by the NIT2 nitrogen regulatory protein: importance of the number, spacing, and orientation of GATA core elements and their flanking sequences upon NIT2 binding. Chiang, T.Y., Marzluf, G.A. Biochemistry (1994) [Pubmed]
  4. Expression of the Avirulence gene Avr9 of the fungal tomato pathogen Cladosporium fulvum is regulated by the global nitrogen response factor NRF1. Pérez-García, A., Snoeijers, S.S., Joosten, M.H., Goosen, T., De Wit, P.J. Mol. Plant Microbe Interact. (2001) [Pubmed]
  5. Nitrogen limitation induces expression of the avirulence gene avr9 in the tomato pathogen Cladosporium fulvum. Van den Ackerveken, G.F., Dunn, R.M., Cozijnsen, A.J., Vossen, J.P., Van den Broek, H.W., De Wit, P.J. Mol. Gen. Genet. (1994) [Pubmed]
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