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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ENTPD7  -  ectonucleoside triphosphate...

Homo sapiens

Synonyms: Ectonucleoside triphosphate diphosphohydrolase 7, FLJ30978, LALP1, Lysosomal apyrase-like protein 1, NTPDase 7
 
 
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Disease relevance of ENTPD7

  • By means of CM-Sephadex C-25, DEAE-Sephadex A-50, Sephadex G-200, and Sephadex G-75 chromatographies, a lupus anticoagulant like protein (LALP) from Agkistrodon halys brevicaudus was purified [1].
  • We have measured the main circulating alkaline phosphatase isoenzymes--bone (BALP), liver (LALP), intestinal (IALP), placental (PALP)--in six families with hypophosphatasia, using kinetic and electrophorectic methods [2].
  • The evaluation included the following antigen forms: (a) commercially available preparations of human bone ALP (BALP) and liver ALP (LALP); (b) human BALP isoforms, B/I, B1 and B2; and (c) soluble secreted epitope-tagged recombinant human TNALP (setTNALP) expressed in COS-1, osteosarcoma (SaOS-2) and hepatoma (Huh2) cell lines [3].
 

High impact information on ENTPD7

  • The units of BALP present, but not of LALP, were related to measures of thyroid function [4].
 

Analytical, diagnostic and therapeutic context of ENTPD7

  • On SDS-PAGE, the purified LALP had a molecular weight of 25,500 daltons under non-reducing condition and 15,000 daltons under reducing condition [1].

References

  1. Purification and characterization of lupus anticoagulant like protein from Agkistrodon halys brevicaudus venom. Li, Z.Y., Wu, X.W., Yu, T.F., Lian, E.C. Thromb. Haemost. (1996) [Pubmed]
  2. Alkaline phosphatase isoenzymes and clinical features in hypophosphatasia. Iqbal, S.J., Davies, T., Holland, S., Manning, T., Whittaker, P. Ann. Clin. Biochem. (2000) [Pubmed]
  3. Monoclonal antibodies against tissue-nonspecific alkaline phosphatase. Report of the ISOBM TD9 workshop. Magnusson, P., Arlestig, L., Paus, E., Di Mauro, S., Testa, M.P., Stigbrand, T., Farley, J.R., Nustad, K., Millán, J.L. Tumour Biol. (2002) [Pubmed]
  4. Tissue sources of elevated serum alkaline phosphatase activity in hyperthyroid patients. Rhone, D.P., Berlinger, F.G., White, F.M. Am. J. Clin. Pathol. (1980) [Pubmed]
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