Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

TRIM49 - tripartite motif containing 49

Homo sapiens

Synonyms: RING finger protein 18, RNF18, TRIM49A, TRIM49L2, Testis-specific RING-finger protein, ...

Yoshikawa, T. et al.

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Disease relevance of TRIM49

A database search showed that the RNF18 gene had the moderate similarity to SS-A/Ro52 protein, which is a ribonucleoprotein reactive with autoantibodies in patients with Sjögren's syndrome and systemic lupus erythematosus [1].

High impact information on TRIM49

Tissue distribution analyses by Northern blot and RT-PCR methods demonstrated that the RNF18 messenger RNA was preferentially expressed in testis [1].
The exon-intron boundaries of RNF18 gene were determined by aligning the cDNA sequence with the corresponding genome sequence [1].
The precise chromosomal location of the RNF18 gene was determined by PCR-based radiation hybrid mapping, and the gene was located to centromere region of chromosome 11 between markers NIB1900 and D11S1350 [1].

References

Isolation of a cDNA for a novel human RING finger protein gene, RNF18, by the virtual transcribed sequence (VTS) approach(1). Yoshikawa, T., Seki, N., Azuma, T., Masuho, Y., Muramatsu, M., Miyajima, N., Saito, T. Biochim. Biophys. Acta (2000) [Pubmed]

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