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Gene Review

PSMD5  -  proteasome (prosome, macropain) 26S...

Homo sapiens

Synonyms: 26S protease subunit S5 basic, 26S proteasome non-ATPase regulatory subunit 5, 26S proteasome subunit S5B, KIAA0072, S5B
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Disease relevance of PSMD5

  • This interaction is demonstrated by the different susceptibility of Osborne-Mendel (OM) and S5B/P1 rat strains to obesity when offered a high-fat diet [1].

High impact information on PSMD5

  • Immunohistochemical studies demonstrated that Osborne-Mendel rats eating a chow diet had an increased number of mu opioid receptors in the arcuate nucleus when compared to S5B/Pl rats [2].
  • These immunohistochemical findings were supported by Real Time-PCR which demonstrated that the mRNA level of mu opioid receptors was also increased in the hypothalamus of Osborne-Mendel rats compared to S5B/Pl rats [2].
  • The same doses of DAMGO switched the diet preference of S5B/Pl rats to high fat but did not significantly increase food intake [2].
  • In satiated S5B rats, GHRP-2 stimulated intake of the LF diet in a dose dependent manner but did not affect the intake of the HF diet [3].
  • In addition, a differential regulation of ghrelin gene expression between OM and S5B rats may be important in their differential sensitivity to HF diet-induced obesity [3].

Analytical, diagnostic and therapeutic context of PSMD5

  • We have investigated these hypotheses in two strains of rat, the Osborne-Mendel (OM) rat that prefers diets high in fat and is sensitive to dietary obesity and the S5B/P1 (S5B) rat that prefers a low fat diet and is resistant to high fat diet induced obesity [3].


  1. Differential expression of leptin receptor in high- and low-fat-fed Osborne-Mendel and S5B/Pl rats. Madiehe, A.M., Schaffhauser, A.O., Braymer, D.H., Bray, G.A., York, D.A. Obes. Res. (2000) [Pubmed]
  2. Increased expression of mu opioid receptors in animals susceptible to diet-induced obesity. Barnes, M.J., Holmes, G., Primeaux, S.D., York, D.A., Bray, G.A. Peptides (2006) [Pubmed]
  3. Regulation of ghrelin gene expression in stomach and feeding response to a ghrelin analogue in two strains of rats. Liu, X., York, D.A., Bray, G.A. Peptides (2004) [Pubmed]
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