Chemical Compound Review:
Pralmorelin (2S)-6-amino-2-[[(2R)-2- [[(2S)-2-[[(2S)-2...
Synonyms:
GHRP 2, GHRP-2 Acetate, SureCN3055328, AC1NUU5W, KP 102, ...
Doi,
Hirotani,
Ukai,
Shimada,
Okuno,
Kurasaki,
Kiyofuji,
Ikegami,
Futamata,
Nakagawa,
Ase,
Chihara,
Veldhuis,
Evans,
Bowers,
Tschöp,
Statnick,
Suter,
Heiman,
Weekers,
Van Herck,
Isgaard,
Van den Berghe,
Veldhuis,
Iranmanesh,
Bowers,
Hirotani,
Oki,
Ukai,
Okuno,
Kurasaki,
Ohyama,
Doi,
Sasaki,
Ase,
Furuta,
Hori,
Ohyama,
- Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men. Laferrère, B., Abraham, C., Russell, C.D., Bowers, C.Y. J. Clin. Endocrinol. Metab. (2005)
- Pretreatment with growth hormone-releasing peptide-2 directly protects against the diastolic dysfunction of myocardial stunning in an isolated, blood-perfused rabbit heart model. Weekers, F., Van Herck, E., Isgaard, J., Van den Berghe, G. Endocrinology (2000)
- KP-102 (growth hormone-releasing peptide-2) attenuates ischemia/reperfusion injury in isolated rat hearts. Furuta, S., Hori, T., Ohyama, T. Naunyn Schmiedebergs Arch. Pharmacol. (2006)
- Growth hormone-releasing peptide-2 infusion synchronizes growth hormone, thyrotrophin and prolactin release in prolonged critical illness. Van den Berghe, G., Wouters, P., Bowers, C.Y., de Zegher, F., Bouillon, R., Veldhuis, J.D. Eur. J. Endocrinol. (1999)
- Neurokinin receptor antagonists inhibit the binding of growth hormone-releasing peptide to EP-1 human neuroblastoma cells. Tai, S., Kaji, H., Okimura, Y., Abe, H., Chihara, K. Biochem. Biophys. Res. Commun. (1995)
- Protein kinase C-dependent growth hormone releasing peptides stimulate cyclic adenosine 3',5'-monophosphate production by human pituitary somatotropinomas expressing gsp oncogenes: evidence for crosstalk between transduction pathways. Adams, E.F., Lei, T., Buchfelder, M., Bowers, C.Y., Fahlbusch, R. Mol. Endocrinol. (1996)
- Pharmacological characteristics of KP-102 (GHRP-2), a potent growth hormone-releasing peptide. Doi, N., Hirotani, C., Ukai, K., Shimada, O., Okuno, T., Kurasaki, S., Kiyofuji, T., Ikegami, R., Futamata, M., Nakagawa, T., Ase, K., Chihara, K. Arzneimittel-Forschung. (2004)
- Pharmacokinetics and pharmacodynamics of growth hormone-releasing peptide-2: a phase I study in children. Pihoker, C., Kearns, G.L., French, D., Bowers, C.Y. J. Clin. Endocrinol. Metab. (1998)
- Ghrelin receptor agonist GHRP-2 prevents arthritis-induced increase in E3 ubiquitin-ligating enzymes MuRF1 and MAFbx gene expression in skeletal muscle. Granado, M., Priego, T., Martín, A.I., Villanúa, M.A., López-Calderón, A. Am. J. Physiol. Endocrinol. Metab. (2005)
- The role of protein kinase C in GH secretion induced by GH-releasing factor and GH-releasing peptides in cultured ovine somatotrophs. Wu, D., Clarke, I.J., Chen, C. J. Endocrinol. (1997)
- Effects of growth hormone-releasing peptide-2 (GHRP-2) on membrane Ca2+ permeability in cultured ovine somatotrophs. Chen, C., Clarke, I.J. J. Neuroendocrinol. (1995)
- The growth hormone-releasing peptide KP-102 induces c-fos expression in the arcuate nucleus. Kamegai, J., Hasegawa, O., Minami, S., Sugihara, H., Wakabayashi, I. Brain Res. Mol. Brain Res. (1996)
- Anti-inflammatory effect of the ghrelin agonist growth hormone-releasing peptide-2 (GHRP-2) in arthritic rats. Granado, M., Priego, T., Martín, A.I., Villanúa, M.A., López-Calderón, A. Am. J. Physiol. Endocrinol. Metab. (2005)
- ACTH releasing activity of KP-102 (GHRP-2) in rats is mediated mainly by release of CRF. Hirotani, C., Oki, Y., Ukai, K., Okuno, T., Kurasaki, S., Ohyama, T., Doi, N., Sasaki, K., Ase, K. Naunyn Schmiedebergs Arch. Pharmacol. (2005)
- Impact of estradiol supplementation on dual peptidyl drive of GH secretion in postmenopausal women. Veldhuis, J.D., Evans, W.S., Bowers, C.Y. J. Clin. Endocrinol. Metab. (2002)
- Effects of GHRP-2 and hexarelin, two synthetic GH-releasing peptides, on GH, prolactin, ACTH and cortisol levels in man. Comparison with the effects of GHRH, TRH and hCRH. Arvat, E., di Vito, L., Maccagno, B., Broglio, F., Boghen, M.F., Deghenghi, R., Camanni, F., Ghigo, E. Peptides (1997)
- Effect of D-Ala-D-beta Nal-Ala-Trp-D-Phe-Lys-NH2 (KP-102) on GH secretion in urethan-anesthetized rats. Sawada, H., Sugihara, H., Onose, H., Minami, S., Shibasaki, T., Wakabayashi, I. Regul. Pept. (1994)
- GH-releasing peptide-2 increases fat mass in mice lacking NPY: indication for a crucial mediating role of hypothalamic agouti-related protein. Tschöp, M., Statnick, M.A., Suter, T.M., Heiman, M.L. Endocrinology (2002)
- Joint mechanisms of impaired growth-hormone pulse renewal in aging men. Veldhuis, J.D., Iranmanesh, A., Bowers, C.Y. J. Clin. Endocrinol. Metab. (2005)
- A five day treatment with daily subcutaneous injections of growth hormone-releasing peptide-2 causes response attenuation and does not stimulate insulin-like growth factor-I secretion in healthy young men. Nijland, E.A., Strasburger, C.J., Popp-Snijders, C., van der Wal, P.S., van der Veen, E.A. Eur. J. Endocrinol. (1998)