Disease relevance of SCYL3

• Characterization of PACE-1 in human breast cancer cell lines demonstrates it to have two distinct intracellular localizations [1].
• Prevalence and characteristics of escape rhythms after radiofrequency ablation of the atrioventricular junction: results from the registry for AV junction ablation and pacing in atrial fibrillation. Ablate and Pace Trial Investigators [2].
• METHODS.: Normal and tumorigenic ovarian surface epithelial cells were isolated as described by Roby and coworkers [Roby KF, Taylor CC, Sweetwood JP, Cheng Y, Pace JL, Tawpik O, Persons DL, Smith PG, Terranova PF, Development of a syngeneic mouse model for events related to ovarian cancer. Carcinogen 2000;21 (4):585. [1]] [3].

High impact information on SCYL3

• In contrast, PACE-1 colocalises with ezrin in the lamellipodia, where ezrin has a role in cell spreading and motility [1].
• Together these data suggest that PACE-1 may play a role in regulating cell adhesion/migration complexes in migrating cells [1].
• Previous studies suggested that in 8 M urea barnase unfolds more completely than ribonuclease T1, even with the disulfide bonds broken [Pace, C.N., Laurents, D. V., & Thomson, J.A. (1990) Biochemistry 29, 2564-2572] [4].
• In each instance, Siri's and Pace and Rathburn's equations were used to derive the remaining parameters of body composition: D, total body fat (TBF), TBW, and LBM [5].

Biological context of SCYL3

• This distribution is dependent upon the presence of the PACE-1 N-terminal myristoylation consensus sequence but is not dependent on an association with ezrin [1].

Other interactions of SCYL3

• We describe here the identification and cloning of a novel protein, PACE-1, which binds to the C-terminal domain of ezrin [1].

Analytical, diagnostic and therapeutic context of SCYL3

• (4) The resulting system exhibits 4 types of oscillatory behaviour which correspond to the Trot, Pace, Gallop and Bound gaits of quadruped locomotion [6].

References