Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

PTGER2 - prostaglandin E receptor 2 (subtype EP2),...

Homo sapiens

Synonyms: EP2, PGE receptor EP2 subtype, PGE2 receptor EP2 subtype, Prostaglandin E2 receptor EP2 subtype, Prostanoid EP2 receptor

Nilsson, S.F. et al., Dijkstra, B.G. et al., Takahashi, H.K. et al., Woodward, D.F. et al.

Nilsson, Drecoll, Lütjen-Drecoll, Toris, Krauss, Kharlamb, Nieves, Guerra, Woodward,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on PTGER2

The prostanoid EP2 receptor agonist butaprost increases uveoscleral outflow in the cynomolgus monkey [1].
Although the prostanoid EP2 receptor is structurally and functionally distinct from the FP receptor, the effects of EP2 and FP receptor stimulation on aqueous humor outflow are similar [1].
Perfusion with PGE1 is suggested to increase flow through the trabecular meshwork by stimulation of prostanoid EP2 receptor subtype, EP4 receptor subtype, or both, coupled to G(s) protein, inducing activation of the adenylyl cyclase catalytic unit [2].
Identification of 19 (R)-OH prostaglandin E2 as a selective prostanoid EP2-receptor agonist [3].

Anatomical context of PTGER2

ONO-AE1-259-01 a prostanoid EP2-receptor agonist, ONO-AE1-329, a prostanoid EP4-receptor agonist, and ONO-1301 inhibited TNF-alpha production and T-cell proliferation [4].

Associations of PTGER2 with chemical compounds

PURPOSE: To investigate the ocular hypotensive effect of the prostanoid EP2 receptor agonist butaprost and to establish its mechanism of action [1].

References

The prostanoid EP2 receptor agonist butaprost increases uveoscleral outflow in the cynomolgus monkey. Nilsson, S.F., Drecoll, E., Lütjen-Drecoll, E., Toris, C.B., Krauss, A.H., Kharlamb, A., Nieves, A., Guerra, T., Woodward, D.F. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
Flow after prostaglandin E1 is mediated by receptor-coupled adenylyl cyclase in human anterior segments. Dijkstra, B.G., Schneemann, A., Hoyng, P.F. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
Identification of 19 (R)-OH prostaglandin E2 as a selective prostanoid EP2-receptor agonist. Woodward, D.F., Protzman, C.E., Krauss, A.H., Williams, L.S. Prostaglandins (1993) [Pubmed]
Differential effect of prostaglandins E1 and E2 on lipopolysaccharide-induced adhesion molecule expression on human monocytes. Takahashi, H.K., Iwagaki, H., Tamura, R., Katsuno, G., Xue, D., Sugita, S., Mori, S., Yoshino, T., Tanaka, N., Nishibori, M. Eur. J. Pharmacol. (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

PTGER2	Bos taurus
PTGER2	Canis lupus familiaris
ptger2a	Danio rerio
ptger2b	Danio rerio
PTGER2	Gallus gallus
PTGER2	Macaca mulatta
Ptger2	Mus musculus
PTGER2	Pan troglodytes
Ptger2	Rattus norvegicus
ptger2	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.